Craniotomy for Aneurysm

Lewis X and Sialyl Lewis X Glycosphingolipids.

“…Previous studies have shown expression of Lex and sLex epitopes on hematopoietic stem cells (75), myeloid precursors, monocytes and neutrophils (1,2,76,77). Both Lex and sLex GSLs have been reported in myeloblastic leukemia (58,77), suggesting that Lex and sLex GSLs may be expressed by early myeloid precursors (Table II).…”

“…Lex and sLex Glycosphingolipids in Colon Cancer Lex and sLex determinants are expressed on gastrointestinal epithelia early in fetal development, with expression decreasing with increasing gestational age (15). In adults, Lex epitopes are detected in intestinal crypts (1). Sialyl Lex determinants are generally not expressed on adult gastrointestinal mucosa (15) although weak staining was reported to intestinal glands and goblet cells with the anti-sLex mAb, KM-93, (76) on immunohistochemistry.…”

“…As with human intestine, Lex is not normally expressed on adult human lung (1). In contrast, some sLex antigen can be detected on normal bronchial epithelium and bronchial glands (76) as well as whole lung tissue extracts (27).…”

“…Lex and sLex GSLs in Genitourinary Tract Cancer Unlike lung and colon, Lex and sLex antigens are normally expressed in kidney and bladder (1,2,15,16). Lex and sLex determinants are expressed early in kidney development and persists on proximal renal tubules and the descending loops of Henle (1,2,15,16). Lex antigens are also expressed on adult urethral, uretral and bladder epithelium (1,16).…”

“…Lewis X (Lex) and its sialylated derivative, sialyl Lewis X (sLex), are carbohydrate blood group antigens expressed by neutrophils, monocytes and other cell membranes (1,2). The ©1997FCCA (Forum: Carbohydrates Coming of Age)…”