Craniomandibular Osteopathy with a Unique Neurological Manifestation in a Young Akita

Ratterree, William; Glassman, Mathieu; Driskell, Elizabeth A.; Havig, Marc E.

doi:10.5326/jaaha-ms-5464

Cited by 16 publications

(25 citation statements)

References 10 publications

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“…CHS shares clinical and histologic similarities with craniomandibular osteopathy (CMO) 2 and human infantile cortical hyperostosis (ICH); 3 however, there are several distinctive features of CHS. CHS presents as a focal osteopathy, often unilateral, with a predilection of the flat bones of the skull, 1,4 while CMO and ICH are bilateral and may affect the appendicular skeleton 2,3,5,6 . CMO predominantly affects the mandible bilaterally 7,8 and has been reported in many breeds including the West Highland White Terrier, 7 Labrador, 9 Boxer, 10 Doberman Pinscher, 11 Shetland Sheepdog, 8 Great Dane, 12 Great Pyrenean Mountain Dog, 13 Akita, 5 and English Bulldog 14 .…”

Section: Introductionmentioning

confidence: 99%

Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel

Mathes

Holmes

Coleman

et al. 2011

Veterinary Ophthalmology

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A 4-month-old intact female English Springer Spaniel presented to the University of Georgia Veterinary Teaching Hospital for evaluation of unilateral, progressive exophthalmos oculus sinister (OS) of 2 weeks' duration. Complete ophthalmic examination revealed moderate OS exophthalmos and lateral globe deviation. No other abnormalities were noted on physical or ophthalmic examination, ocular ultrasound, complete bloodwork, or thoracic radiography. Skull computed tomography (CT) revealed a large, focal, smoothly irregular, cavitated, expansile bony lesion involving the left caudal maxillary and left frontal bones. Biopsies, obtained through a frontal sinusotomy approach to preserve the left globe integrity, demonstrated normal reactive trabecular bone with locally extensive fibrosis. Calvarial hyperostosis was diagnosed based upon appearance on imaging, lesion unilaterality, absence of mandibular involvement, and histopathology. Six months after initial presentation, skull CT was repeated and marked reduction in the degree of frontal bone thickening was demonstrated with complete resolution of cavitations. There was marked clinical improvement with mild, nonpainful exophthalmos, and lateral globe deviation OS on ophthalmic examination. Eleven months after initial presentation, there was complete resolution of the frontal bone lesion with mild thickening of the left calvarial bones on repeat skull CT. There was no exophthalmos or globe deviation present on clinical ophthalmic examination. The proliferative osteopathic lesion was self-resolving with resolution of the exophthalmos and has not recurred to date. To the authors' knowledge, this is the first report of calvarial hyperostosis in a previously unreported breed presenting as unilateral exophthalmos.

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Section: Introductionmentioning

confidence: 99%

Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel

Mathes

Holmes

Coleman

et al. 2011

Veterinary Ophthalmology

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“…Commonly involved bones of the skull include the frontal, parietal, and occipital bones, the tympanic bullae, the mandibular rami, and the temporomandibular joints . It has been reported in a variety of small and large breed dogs . Cairn Terriers, Scottish Terriers, and West Highland White Terriers have been cited to have an increased risk of the disease .…”

Section: Discussionmentioning

confidence: 99%

Imaging Diagnosis—magnetic Resonance Imaging Features of Craniomandibular Osteopathy in an Airedale Terrier

Matiasovic¹,

Caine²,

Scarpante³

et al. 2015

Vet Radiology Ultrasound

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An Airedale Terrier was presented for evaluation of depression and reluctance to be touched on the head. Magnetic resonance (MR) imaging of the head was performed. The images revealed bone lesions affecting the calvarium at the level of the coronal suture and left mandibular ramus, with focal cortical destruction, expansion, and reactive new bone formation. Skull lesions were hypointense on T1-weighted sequences, hyperintense on T2-weighted sequences, and showed an intense and homogeneous enhancement after gadolinium administration. Reactive new bone formation and periosteal proliferation were confirmed histopathologically. The clinical signs, imaging findings, and histopathological examination were consistent with craniomandibular osteopathy.

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“…No data describing this disease in other species are available. Canine CMO most commonly occurs in West Highland white terriers, and it has also been described in other breeds, including Scottish terriers, Airedale terriers, Akitas, labrador retrievers, Great Danes, bullmastiffs, Doberman pinschers, cairn terriers, Pyrenean mountain dogs, boxers, Boston terriers, Deutsch Drahthaar dogs and an English bulldog 3–19…”

Section: Introductionmentioning

confidence: 99%

“…CMO is usually recognised in dogs aged four to seven months. Palpable or grossly visible proliferative changes are seen on the skull bones and sometimes the long bones, and are associated with discomfort while chewing, an inability to open the mouth, difficulties in locomotion or neurological problems 13 15–17 20…”

Section: Introductionmentioning

confidence: 99%

Craniomandibular osteopathy in a golden jackal (Canis aureus)

Marinković

Macanović

Krstić

et al. 2019

Vet Record Case Reports

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Craniomandibular osteopathy is a rare disorder in dogs, characterised by subperiosteal and extraperiosteal new bone proliferations on the skull, on the mandibles in particular and occasionally on long bones. Data about craniomandibular osteopathy in the golden jackal (Canis aureus) are lacking. This paper describes craniomandibular osteopathy in a seven-month-old animal. The mandibular region and the distal section of the hindlimb were examined radiologically and by CT. Both imaging modalities showed ossifying periosteal deposits localised on the left side of the mandible and irregular periosteal ossifying deposits covering the surface of the crural bones. Histopathology revealed new bone formation in the endosteum, periosteum and trabecular bone of the mandible and in the distal section of the hindlimb, but no inflammatory cells were found. Craniomandibular osteopathy in free-living canids has not yet been reported. However, the macroscopic imaging and histopathological features in this pup were consistent with the disease.

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Craniomandibular Osteopathy with a Unique Neurological Manifestation in a Young Akita

Cited by 16 publications

References 10 publications

Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel

Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel

Imaging Diagnosis—magnetic Resonance Imaging Features of Craniomandibular Osteopathy in an Airedale Terrier

Craniomandibular osteopathy in a golden jackal (Canis aureus)

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