Craniofacial Resection for Malignant Melanoma of the Skull Base

Ganly, Ian; Patel, Snehal G.; Singh, Bhuvanesh; Kraus, Dennis H.; Bridger, Patrick G.; Cantù, G.; Cheesman, A. D.; De, Geraldo; Donald, Paul J.; Fliss, Dan M.; Gullane, Patrick; Janecka, Ivo P.; Kamata, Shin Etsu; Kowalski, Luiz Paulo; Levine, Paul A.; Santos, Luiz Roberto Medina dos; Pradhan, Sangram K.; Schramm, Victor L.; Snyderman, Carl H.; Wei, William I.; Shah, Jatin P.

doi:10.1001/archotol.132.1.73

Cited by 45 publications

(8 citation statements)

References 20 publications

(23 reference statements)

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“…A meta-analysis from 2012 could not reveal higher survival rates 437 . Other study results confirm an increased 3-year survival rate from 18 to 30% as well as a reduced local recurrence rate after postoperative radiotherapy 438 439 . Treatment with anti-PD-1 antibodies as well as anti-CTLA-4 antibodies show promising results in advanced or metastasized mucosal melanomas, however, the evidence is too low to justify their clinical application 436 440 .…”

Section: Rare Diseases Of the Nose The Paranasal Sinuses And The Snterior Skull Basesupporting

confidence: 57%

Seltene Erkrankungen der Nase, der Nasennebenhöhlen und der vorderen Schädelbasis

Sommer

2021

Laryngorhinootologie

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ZusammenfassungSeltene Erkrankungen der Nase, der Nasennebenhöhlen und der vorderen Schädelbasis stellen aufgrund der niedrigen Inzidenz und den daraus resultierend eingeschränkten diagnostischen Kriterien sowie therapeutischen Optionen eine Herausforderung dar. Der Schwellenwert, ab dem eine Erkrankung als selten zu werten ist, liegt bei höchstens 5 Betroffenen pro 10 000 Personen. Innerhalb dieser Erkrankungen gibt es allerdings extreme Schwankungen. So gehören einige seltene Erkrankungen, wie z.B. das invertierte Papillom, zu den regelmäßig diagnostizierten und therapierten Krankheitsbildern einer größeren Klinik für Hals-Nasen-Ohrenheilkunde. Andererseits liegen bei anderen seltenen Erkrankungen und Fehlbildungen weltweit deutlich unter 100 Fallberichte vor, was die Notwendigkeit einer Bündelung der verfügbaren Erfahrung zu Diagnostik und Therapie unterstreicht.Die vorliegende Arbeit gibt eine Übersicht zu seltenen Erkrankungen der Nase, der Nasennebenhöhlen und der vorderen Schädelbasis aus den übergeordneten Bereichen Erkrankungen / Syndrome des olfaktorischen Systems, Fehlbildungen der Nase und Nasennebenhöhlen, Belüftungs- und Funktionsstörungen sowie benigne und maligne Tumore. Die Einordnung sowie Angaben zu Diagnostik und Therapiemöglichkeiten wurden unter Berücksichtigung der aktuellen Literatur erstellt.

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Section: Rare Diseases Of the Nose The Paranasal Sinuses And The Snterior Skull Basesupporting

confidence: 57%

Seltene Erkrankungen der Nase, der Nasennebenhöhlen und der vorderen Schädelbasis

Sommer

2021

Laryngorhinootologie

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“…To date, the best outcome studies of these tumours are from the International Collaborative Study, which published their results most recently in 2006 (1,3,17,18). In this multicentre case series, in which our institution was included, data from 1307 patients were acquired retrospectively.…”

Section: Resultsmentioning

confidence: 99%

Surgical Approaches to Resection of Anterior Skull Base and Paranasal Sinuses Tumors

Abu‐Ghanem

Fliss

2013

Balkan Med J

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IntroductionTumours involving the anterior skull base and paranasal sinuses are challenging to treat because of their relative rarity, the wide diversity of tumour types represented, and the variability in the extent of involved local structures (1).The route of spread of these tumours is determined by the complex anatomy of the craniomaxillofacial compartments. These tumours may invade laterally into the orbit and middle fossa, inferiorly into the maxillary antrum and palate, posteriorly into the nasopharynx and pterygopalatine fossa (PPF), and superiorly into the cavernous sinus and brain. Surgery remains the important modality of treatment of anterior skull base tumours. Combined craniofacial techniques for the resection of tumours of the anterior skull base were first described by Ketcham et al. (2) in 1963. Since then, anterior skull base surgery has evolved greatly, with a better understanding of the anatomy, pathology, imaging and surgical techniques. The craniofacial approach and the subcranial approach have become the standard of care for the treatment of malignant tumours involving the anterior skull base (3-6) and, because of this and the varied histologic findings, most outcomes data reflect the experience of small patient cohorts. This International Collaborative study examines a large cohort of patients accumulated from multiple institutions experienced in craniofacial surgery, with the aim of reporting benchmark figures for outcomes and identifying patient-related and tumor-related predictors of prognosis after craniofacial resection (CFR. Recent developments in technology have allowed the use of endoscopic endonasal approaches. Nevertheless, several problems still exist, relating to case selection, histology, cost, patient selection, and the experience of the surgeon. This review focuses on the open surgical resection approaches used for anterior skull base tumours, as used in our institution in the last 20 years. AnatomyThe anterior skull base is a complex anatomical compartment. It can be defined as the portion of the skull base adjacent to the anterior cranial fossa. The anterior skull base boundaries include the medial border that is formed by the cribriform plate, making up the roof of the nasal cavity, the lateral border that is formed by the orbital plates of the frontal bone that form the roof of the orbits and ethmoid air cells, and the posterior border that is formed by the planum sphenoidale and lesser wings of the sphenoid (4).The cribiform plate is traversed by multiple olfactory nerves that extend from the olfactory mucosa to the olfactory bulbs. A bony fissure between the lesser and greater sphenoid wings, the superior orbital fissure, gives passage to cranial nerves III, IV, V and VI and to the superior ophthalmic vein. Superior and laterally lies the optic canal bordered by the body of the sphenoid and by the superior and inferior roots of the lesser sphenoid wing, giving passage to the optic nerve, ophthalmic artery, and sympathetic nerves. However, both the superior orbital fi...

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“…The results of skull base resection for mucosal malignant melanoma have been very poor [9]. Also, while good local control can be obtained with carbon ion radiotherapy, distant metastasis reduces survival rates [10].…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Malignant Melanoma of the Sphenoid Sinus

Tsukahara

Nakamura

Motohashi

et al. 2013

Case Reports in Otolaryngology

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Malignant melanoma of the sphenoid sinus is a very rare disease, and only 6 cases have previously been reported. The present case involved a 74-year-old woman who was examined for visual disturbance of the left eye. Computed tomography revealed a soft tissue shadow, but only mucosal hypertrophy was found on opening the sphenoid sinus under general anesthesia. One month postoperatively, visual disturbance of the right eye and paresis of cranial nerve III appeared. Malignant melanoma was diagnosed from biopsy. Multiple bone metastases were identified, but the patient declined active treatment. As a result, palliative care was provided and she died 3 months later. When there is no improvement in postoperative visual acuity as in this case, in consideration of the possibility of neoplastic lesions, rigorous followup including monitoring for neurological symptoms is warranted.

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Craniofacial Resection for Malignant Melanoma of the Skull Base

Cited by 45 publications

References 20 publications

Seltene Erkrankungen der Nase, der Nasennebenhöhlen und der vorderen Schädelbasis

Seltene Erkrankungen der Nase, der Nasennebenhöhlen und der vorderen Schädelbasis

Surgical Approaches to Resection of Anterior Skull Base and Paranasal Sinuses Tumors

A Case Report of Malignant Melanoma of the Sphenoid Sinus

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