Craniofacial growth in ectodermal dysplasia

Dellavia, Claudia; Catti, Francesca; Sforza, Chiarella; Tommasi, Davide G.; Ferrario, Virgilio F.

doi:10.2319/101909-584.1

Cited by 17 publications

(19 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1). One article had to be excluded or pooled with another because of possible double publication of the same cohort (Grecchi (b) [15]), one article because of missing follow-up times (Hvaring [16]), one because of missing clinical data (Kjaer [17]), and two articles because of missing numerical data (Dellavia [18, 19]). The study of Bergendal [20] could be kept in the analysis after contacting the author for clarification (no follow-up time reported).…”

Section: Resultsmentioning

confidence: 99%

“…The two studies of Dellavia and coworkers [18, 19] contained drawings (polar diagrams) but not the underlying numerical data. Their evaluation of facial photographies demonstrated that patients with ectodermal dysplasia had a slightly reduced global facial growth in comparison with normal reference peers, with a delay of about 2 years in mandibular and maxillary peak developments.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Occlusal rehabilitation in patients with congenitally missing teeth—dental implants, conventional prosthetics, tooth autotransplants, and preservation of deciduous teeth—a systematic review

Terheyden

Wüsthoff

2015

Int J Implant Dent

View full text Add to dashboard Cite

BackgroundImplant patients with congenitally missing teeth share some common charateristics and deserve special attention.MethodsThe PICO question was “In patients with congenitally missing teeth, does an early occlusal rehabilitation with dental implants in comparison to tooth autotransplants, conventional prosthetics on teeth or preservation of deciduous teeth have better general outcomes in terms of survival, success and better patient centered outcomes in terms of quality of life, self-esteem, satisfaction, chewing function?”After electronic database search, a total of 63 relevant studies were eligible, of which 42 qualified for numerical data synthesis, 26 being retrospective studies. A data synthesis was performed by weighted means for survival/success/annual failure rates.ResultsThe mean survival of implants was 95.3 % (prosthesis survival 97.8 %), autotransplants 94.4 %, deciduous teeth 89.6 %, and conventional prostheses 60.2 %. The implant survival in children, adolescents, and adults was 72.4, 93.0, and 97.4 %. Annual failure rates of implants 3.317 %, autotransplants 1.061 %, deciduous teeth 0.908 %, and conventional prostheses 5.144 % indicated better results for natural teeth and more maintenance needs for the both prosthetic treatments. The mean OHIP score was 27.8 at baseline and a mean improvement of 14.9 score points was reported after implant prosthetics. The mean satisfaction rates were 93.4 (implants), 76.6 (conventional prostheses), 72.0 (autotransplants), and 65.5 % (orthodontic space closure).ConclusionsIn synopsis of general and patient-centered outcomes, implants yielded the best results, however, not in children <13 years. Autotransplants and deciduous teeth had low annual failure rates and are appropriate treatments in children and adolescents at low costs. Conventional prosthetics had lower survival/success rates than the other options. Due to heterogeneity and low number of studies, patient-reported outcomes in this review have to be interpreted with caution.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Occlusal rehabilitation in patients with congenitally missing teeth—dental implants, conventional prosthetics, tooth autotransplants, and preservation of deciduous teeth—a systematic review

Terheyden

Wüsthoff

2015

Int J Implant Dent

View full text Add to dashboard Cite

show abstract

“…Craniofacial and anthropometric changes are also described in XLHED and consist in reduced and retrognathic maxilla, frontal prominence, cranial base modifications, reduced facial convexity and facial height with deficiencies in sagittal and transverse skeletal growth (Johnson et al, 2002; Arslan et al, 2007; Clauss et al, 2008). Global reduction of facial growth, especially in the middle third of the facial skeleton, and mandibular growth retardation are integrated in HED craniofacial phenotype (Dellavia et al, 2010). Bone structural modifications have also been described in patients affected by XLHED and correspond to local increases of alveolar and basal bone densities and hypercorticalization (Lesot et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Subtle Morphological Changes in the Mandible of Tabby Mice Revealed by Micro-CT Imaging and Elliptical Fourier Quantification

Bornert¹,

Choquet²,

Gros³

et al. 2011

Front. Physio.

View full text Add to dashboard Cite

X-linked hypohidrotic ectodermal dysplasia (XLHED) is a genetic disorder due to a mutation of the EDA gene and is mainly characterized by an impaired formation of hair, teeth and sweat glands, and craniofacial dysmorphologies. Although tooth abnormalities in Tabby (Ta) mutant mice – the murine model of XLHED – have been extensively studied, characterization of the craniofacial complex, and more specifically the mandibular morphology has received less attention. From 3D micro-CT reconstructions of the left mandible, the mandibular outline observed in lateral view, was quantified using 2D elliptical Fourier analysis. Comparisons between Ta specimens and their wild-type controls were carried out showing significant shape differences between mouse strains enabling a clear distinction between hemizygous Ta specimens and the other mouse groups (WT and heterozygous EdaTa/+ specimens). Morphological differences associated with HED correspond not only to global mandibular features (restrained development of that bone along dorsoventral axis), but also to subtle aspects such as the marked backward projection of the coronoid process or the narrowing of the mandibular condylar neck. These modifications provide for the first time, evidence of a predominant effect of the Ta mutation on the mandibular morphology. These findings parallel the well described abnormalities of jugal tooth row and skeletal defects in Ta mice, and underline the role played by EDA-A in the reciprocal epithelial–mesenchymal interactions that are of critical importance in normal dental and craniofacial development.

show abstract

“…All changes in the dental arches, including alveolar bone growth in response to tooth eruption, should be monitored to ensure appropriate adjustments are made. Long-term treatment is an active process that must be constantly adapted to the child's development and growth [10]. …”

Section: Discussionmentioning

confidence: 99%

Prosthetic Management of a Child with Hypohidrotic Ectodermal Dysplasia: 6-Year Follow-Up

Pinto

Val

et al. 2016

Case Reports in Dentistry

View full text Add to dashboard Cite

Ectodermal dysplasia (ED) is a genetically heterogeneous condition resulting from clinical anomalies of structures derived from the ectoderm, such as the hair, nails, sweat glands, and teeth. This clinical report presents the case of a child diagnosed with hypohidrotic ED at 2 years of age; clinical and imaging evaluation was performed with 6-year follow-up, and we present details of the prosthetic dental care, with a 12-month follow-up. The patient's masticatory capacity had improved, leading to the child gaining 4 kg. In conclusion, prosthetic management was noninvasive and appeared to lead to developmental benefits for the patient.

show abstract

Craniofacial growth in ectodermal dysplasia

Abstract: The deviation from normal facial growth of HED subjects tends to lessen with age. Functional and prosthetic appliances may have enhanced facial growth.

Cited by 17 publications

References 22 publications

Occlusal rehabilitation in patients with congenitally missing teeth—dental implants, conventional prosthetics, tooth autotransplants, and preservation of deciduous teeth—a systematic review

Occlusal rehabilitation in patients with congenitally missing teeth—dental implants, conventional prosthetics, tooth autotransplants, and preservation of deciduous teeth—a systematic review

Subtle Morphological Changes in the Mandible of Tabby Mice Revealed by Micro-CT Imaging and Elliptical Fourier Quantification

Prosthetic Management of a Child with Hypohidrotic Ectodermal Dysplasia: 6-Year Follow-Up

Contact Info

Product

Resources

About