Cranial growth inSaimiri sciureus (Cebidae) and its alteration by nutritional factors: A longitudinal study

Dressino, Vicente; Pucciarelli, Héctor Mário

doi:10.1002/(sici)1096-8644(199704)102:4<545::aid-ajpa8>3.0.co;2-q

Cited by 25 publications

(19 citation statements)

References 19 publications

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“…Therefore, the head suffered a shape distortion during development that was dependent on the dose of citalopram. The sensitivity of vertebrate head growth to epigenetic manipulations has been well demonstrated (22,23). Changes in the craniofacial skeleton of developing rats submitted to a low protein diet were shown by Miller and German (24).…”

Section: Discussionmentioning

confidence: 57%

Neonatal administration of citalopram delays somatic maturation in rats

Deiró

Manhães-de-Castro

Cabral-Filho³

et al. 2004

Braz J Med Biol Res

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We investigated the somatic maturation of neonate rats treated during the suckling period with citalopram, a selective serotonin reuptake inhibitor. Groups with 6 male neonates were randomly assigned to different treatments 24 h after birth. Each litter was suckled by one of the dams until the 21st postnatal day. Body weight, head axis and tail length were measured daily from the 1st to the 21st postnatal day. Time of ear unfolding, auditory conduit opening, incisor eruption, and eye opening was determined. Pups received 5 mg (Cit5), 10 mg (Cit10) or 20 mg/kg (Cit20) citalopram sc, or saline (0.9% NaCl, w/v, sc). Compared to saline, body weight was lower (24.04%, P < 0.01) for Cit10 from the 10th to the 21st day and for Cit20 from the 6th to the 21st day (38.19%, P < 0.01). Tail length was reduced in the Cit20 group (15.48%, P < 0.001) from the 8th to the 21st day. A reduction in mediolateral head axis (10.53%, P < 0.05) was observed from the 11th to the 21st day in Cit10 and from the 6th to the 21st day in Cit20 (13.16%, P < 0.001). A reduction in anteroposterior head axis was also observed in the Cit20 group (5.28%, P < 0.05) from the 13th to the 21st day. Conversely, this axis showed accelerated growth from the 12th to the 21st day in the Cit5 group (13.05%, P < 0.05). Auditory conduit opening was delayed in the Cit5 and Cit20 groups and incisor eruption was delayed in all citalopram groups. These findings show that citalopram injected during suckling to rats induces body alterations and suggest that the activity of the serotoninergic system participates in growth mechanisms.

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Section: Discussionmentioning

confidence: 57%

Neonatal administration of citalopram delays somatic maturation in rats

Deiró

Manhães-de-Castro

Cabral-Filho³

et al. 2004

Braz J Med Biol Res

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“…It is known that in squirrel monkeys undernutrition caused by a low-protein diet produces a decrease in body and skull size, but not in brain weight, which was supported by the craniofacial morphometric patterns previously described by our group (1,21).…”

Section: Discussionmentioning

confidence: 98%

Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys

Cónsole

Jurado

Oyhenart

et al. 2001

Braz J Med Biol Res

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Undernutrition elicited by a low-protein diet determines a marked reduction of hypophyseal activity and affects the function of the respective target organs. The objective of the present investigation was to study the ultrastructural and quantitative immunohistochemical changes of the different pituitary cell populations in undernourished monkeys that had been previously shown to have significant changes in craniofacial growth. Twenty Saimiri sciureus boliviensis monkeys of both sexes were used. The animals were born in captivity and were separated into two groups at one year of age, i.e., control and undernourished animals. The monkeys were fed ad libitum a 20% (control group) and a 10% (experimental group) protein diet for two years. Pituitaries were processed for light and electron microscopy. The former was immunolabeled with anti-GH, -PRL, -LH, -FSH, -ACTH, and -TSH sera. Volume density and cell density were measured using an image analyzer. Quantitative immunohistochemistry revealed a decrease in these parameters with regard to somatotrophs, lactotrophs, gonadotrophs and thyrotrophs from undernourished animals compared to control ones. In these populations, the ultrastructural study showed changes suggesting compensatory hyperfunction. On the contrary, no significant changes were found in the morphometric parameters or the ultrastructure of the corticotroph population. We conclude that in undernourished monkeys the somatotroph, lactotroph, gonadotroph, and thyrotroph cell populations showed quantitative immunohistochemical changes that can be correlated with ultrastructural findings.

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“…23,[25][26][27] In the present study, the association between malnutrition and dental crowding was found only after the variable pacifier use was identified as being effect modifying, which allowed for a more accurate investigation based on the heterogeneity of effect on the population. We found positive association between malnutrition, based on the W/A index, and dental crowding among those children who did not use pacifiers, that is, the habit of using pacifiers serves as a protection against the occurrence of dental crowding among the children with malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Associação entre déficit de peso e apinhamento na dentição decídua

Thomaz¹,

Valença²

2009

J. Pediatr. (Rio J.)

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Objective: To investigate the relationship between low anthropometric indices and dental crowding in deciduous teething. Methods:We assessed 794 children from 3 to 5 years old, both boys and girls, enrolled in public preschools in the city of São Luís, state of Maranhão, Brazil. Single-stage cluster sampling was used. This is a cross-sectional study, including the administration of a questionnaire, evaluation of dental occlusion and anthropometric assessment. Dental crowding, which is characterized by lack of space for the eruption of teeth in the line of the alveolar crest, is the dependent variable. Weight-for-age (W/A) and height-for-age (H/A) indices were used for anthropometric assessments.Multivariate logistic regression analysis and descriptive analysis of the variables were used. Associations were estimated using odds ratio (OR), and the statistical inference was based on confidence intervals (95%CI). Type I error was set at 5% (alpha = 5%).

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Cranial growth inSaimiri sciureus (Cebidae) and its alteration by nutritional factors: A longitudinal study

Cited by 25 publications

References 19 publications

Neonatal administration of citalopram delays somatic maturation in rats

Neonatal administration of citalopram delays somatic maturation in rats

Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys

Associação entre déficit de peso e apinhamento na dentição decídua

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