Cranial Characteristics, Maxillofacial, and Skull Base Structure of Non-Human Primate (Adult Macaca fascicularis): A Preliminary Study for Cranial Craniotomy Model

Bolly, Hendrikus Masang Ban; Indah, Astrina Rosaria; Faried, Ahmad; Noverina, Rachmawati; Arifin, Muhammad Zafrullah; Wirakusumah, Firman F.

doi:10.15395/mkb.v51n2.1650

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this reason, animal models are often used to test novel treatment strategies. In the maxillofacial field, non-human primates are considered the most appropriate model for human bone ( Hylander, 1979 ; El Deeb et al, 1985 ; Bolly et al, 2019 ), however, the ethical implications and handling difficulties make them a non-viable solution. Similar limitations can be found with companion animals, like cats and dogs, while minipigs, which are currently one of the most used animal models for craniomaxillofacial studies, despite similarities to humans in the biomechanics of mastication ( Vapniarsky et al, 2017 , 2018 ), present high stiffness of both mandibular bone and soft tissues.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Assessment of the Validity of Sheep as a Preclinical Model for Testing Mandibular Fracture Fixation Devices

Orassi

Duda

Heiland

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Mandibular fracture fixation and reconstruction are usually performed using titanium plates and screws, however, there is a need to improve current fixation techniques. Animal models represent an important step for the testing of new designs and materials. However, the validity of those preclinical models in terms of implant biomechanics remains largely unknown. In this study, we investigate the biomechanics of the sheep mandible as a preclinical model for testing the mechanical strength of fixation devices and the biomechanical environment induced on mandibular fractures. We aimed to assess the comparability of the biomechanical conditions in the sheep mandible as a preclinical model for human applications of fracture fixation devices and empower analyses of the effect of such defined mechanical conditions on bone healing outcome. We developed 3D finite element models of the human and sheep mandibles simulating physiological muscular loads and three different clenching tasks (intercuspal, incisal, and unilateral). Furthermore, we simulated fractures in the human mandibular body, sheep mandibular body, and sheep mandibular diastema fixated with clinically used titanium miniplates and screws. We compared, at the power stroke of mastication, the biomechanical environment (1) in the healthy mandibular body and (2) at the fracture sites, and (3) the mechanical solicitation of the implants as well as the mechanical conditions for bone healing in such cases. In the healthy mandibles, the sheep mandibular body showed lower mechanical strains compared to the human mandibular body. In the fractured mandibles, strains within a fracture gap in sheep were generally not comparable to humans, while similar or lower mechanical solicitation of the fixation devices was found between the human mandibular body fracture and the sheep mandibular diastema fracture scenarios. We, therefore, conclude that the mechanical environments of mandibular fractures in humans and sheep differ and our analyses suggest that the sheep mandibular bone should be carefully re-considered as a model system to study the effect of fixation devices on the healing outcome. In our analyses, the sheep mandibular diastema showed similar mechanical conditions for fracture fixation devices to those in humans.

show abstract