Cranial base chordoma – long term outcome and review of the literature

Yoneoka, Yuichiro; Tsumanuma, Itaru; Fukuda, M.; Tamura, Takamitsu; Morii, Ken; Tanaka, Ryusui; Fujii, Yoshiaki

doi:10.1007/s00701-008-1600-3

Cited by 55 publications

(34 citation statements)

References 13 publications

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“…In the patients from our previous study, the actual extensive resection rate was 83.3% [8]. Other papers have reported a total or subtotal resection rate ranging from 61.5% to 91.3% [1,14,15,20,21,46,53,54,56,60]. The resection rate of our current study therefore seems favorable in comparison to previous studies.…”

Section: Discussionsupporting

confidence: 54%

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Chordomas of the skull base and cervical spine: clinical outcomes associated with a multimodal surgical resection combined with proton-beam radiation in 40 patients

et al. 2011

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Previous studies of chordoma have focused on either surgery, radiotherapy, or particular tumor locations. This paper reviewed the outcomes of surgery and proton radiotherapy with various tumor locations. Between 2001 and 2008, 40 patients with chordomas of the skull base and cervical spine had surgery at our hospital. Most patients received proton therapy. Their clinical course was reviewed. Age, sex, tumor location, timing of surgery, extent of resection, and chondroid appearance were evaluated in regard to the progression-free survival (PFS) and overall survival (OS). The primary surgery (PS) group was analyzed independently. The extensive resection rate was 42.5%. Permanent neurological morbidity was seen in 3.8%. Radiotherapy was performed in 75% and the mean dose was 68.9 cobalt gray equivalents. The median follow-up was 56.5 months. The 5-year PFS and OS rates were 70% and 83.4%, respectively. Metastasis was seen in 12.5%. The tumor location at the cranio-cervical junction (CCJ) was associated with a lower PFS (P = 0.007). In the PS group, a younger age and the CCJ location were related to a lower PFS (P = 0.008 and P < 0.001, respectively). The CCJ location was also related to a lower OS (P = 0.043) and it was more common in young patients (P = 0.002). Among the survivors, the median of the last Karnofsky Performance Scale score was 80 with 25.7% of patients experiencing an increase and 11.4% experiencing a decrease. Multimodal surgery and proton therapy thus improved the chordoma treatment. The CCJ location and a younger age are risks for disease progression.

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Section: Discussionsupporting

confidence: 54%

“…The mean dose was 68.9 (55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74) cobalt gray equivalent (CGE). In all but three cases, the radiation was proton-based.…”

Section: Radiation Adjuvant Therapymentioning

confidence: 99%

Chordomas of the skull base and cervical spine: clinical outcomes associated with a multimodal surgical resection combined with proton-beam radiation in 40 patients

et al. 2011

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“…Complete resection is the most effective primary treatment and may include soft and hard tissues with 82% survival rate, 22.6-60.3% of morbidity and 2-7.8% of mortality [9,[12][13][14][15][16]. The most common complications are neurologic deficits (13.9%), cerebrospinal fluid fistula and meningitis [12].…”

Section: Discussionmentioning

confidence: 99%

Synchronous Infrasellar and Cervical Chondroid Chordoma: A Case Report and Review of the Literature

et al. 2017

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We report on a patient who presented in ENT clinic with diplopia accompanied by headache and vomiting. Imaging studies revealed a large expansive heterogeneous mass encroaching on the infrasellar region and cervical spine. Post-intravenous contrast administration revealed a lesion with high enhancement and involvement of the sphenoidal sinus with retroclival extension. Biopsy confirmed the presence of a chondroid chordoma. Treatment included radiation therapy and the patient is currently receiving palliative and supportive care.

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“…18 Remnants of these notochordal branches that have penetrated these sites presumably provide the seed from which subsequent ectopic chordomas may grow. 19,20 The appearance of chordoma on CT images was that of a well-circumscribed, expansible soft tissue mass that arises from the nasal cavity, with linear calcification in 1 patient. In 4 patients, the lesions showed predominantly lobular morphologic features in the nasopharyngeal area with irregular focal calcification.…”

Section: Discussionmentioning

confidence: 99%

Primary Chordoma in the Nasal Cavity and Nasopharynx: CT and MR Imaging Findings

Zhang¹,

Yang²,

Wang³

et al. 2009

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Primary chordoma in the nasal cavity and nasopharynx is an extremely rare tumor in the extraosseous axial skeleton. Unlike intracranial chordomas, lesions in these sites primarily present as a soft tissue mass without involvement of the skull base bone (clivus), so the preoperative diagnosis of the tumor is possibly difficult. Here, we reviewed the imaging features of 5 cases of chordomas in the nasal cavity and nasopharynx that resulted in successful diagnosis and differential diagnosis of this rare tumor.

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Cranial base chordoma – long term outcome and review of the literature

Cited by 55 publications

References 13 publications

Chordomas of the skull base and cervical spine: clinical outcomes associated with a multimodal surgical resection combined with proton-beam radiation in 40 patients

Chordomas of the skull base and cervical spine: clinical outcomes associated with a multimodal surgical resection combined with proton-beam radiation in 40 patients

Synchronous Infrasellar and Cervical Chondroid Chordoma: A Case Report and Review of the Literature

Primary Chordoma in the Nasal Cavity and Nasopharynx: CT and MR Imaging Findings

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