Primary Chordoma in the Nasal Cavity and Nasopharynx: CT and MR Imaging Findings

Zhang, Yan; Yang, Bentao; Wang, Z.C.; Jian, Xian; Li, M.

doi:10.3174/ajnr.a1802

Cited by 26 publications

(31 citation statements)

References 23 publications

(19 reference statements)

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“…However, presence of a well-defined lobular or expansile soft tissue mass, focal amorphous calcification, intratumor septa, heterogenous hyperintensity on T2-weighted imaging, and mild to moderate enhancement may be suggestive of chordoma [8]. Our patient's radiological imaging showed most of these features.…”

Section: Discussionmentioning

confidence: 58%

Unusual Presentation of Chordoma in Nose

Gupta

Rathore

Chauhan

et al. 2015

Indian J Otolaryngol Head Neck Surg

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Chordomas are uncommon tumors of the bone representing 1-4 % of all primary bone tumors. These typically involve axial skeleton. Primary nasal presentation of chordoma is a rare occurrence and is usually misdiagnosed till the histopathological confirmation. We present a case of chordoma in nasal cavity treated by wide local resection and also present a review of literature discussing various facets in its presentation and management.

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Section: Discussionmentioning

confidence: 58%

Unusual Presentation of Chordoma in Nose

Gupta

Rathore

Chauhan

et al. 2015

Indian J Otolaryngol Head Neck Surg

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“…Imaging diagnostics are based on CT and MRI scans of the area occupied by the tumor, however, the two techniques provide non-specific images of the lesion (37). Chordomas are not chemotherapy-sensitive tumors, therefore, the typical treatment strategy is radical surgery.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal chordoma in a patient with a severe form of sleep-disordered breathing: A case report

Radzikowska¹,

Gronkiewicz²,

Kukwa³

et al. 2015

Oncology Letters

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Abstract. Nasopharyngeal chordoma is a rare type of malignant neoplasm that originates in the remnants of the notochord, a primitive tissue of embryonic origin preserved outside the axial skeleton. Approximately one-third of chordomas are located in the base of the skull, in the midline of the body. The slow growth rate of the tumor, which gradually fills the nasopharyngeal cavity, contributes to a delayed oncological diagnosis. Among its isolated and non-specific symptoms, the obstruction of the nasopharynx is dominant, thus, sleep-disordered breathing (SDB) may occur. The current study presents the case of a 32-year-old female patient who was incidentally diagnosed with a nasopharyngeal chordoma during a diagnostic examination for SDB. The diagnostic examination was performed as a part of a research program for pathologically obese patients who qualified for bariatric surgery. Following tumor resection, a significant improvement in various polysomnographic parameters occurred, including a decrease in the apnea hypopnea index from 53.5 to 6.4 and an increase in the mean saturation rate from 92.5 to 95%, confirming that an association exists between tumor obstruction of the nasopharynx and SDB. The incidental diagnosis of this rare type of neoplasm drew attention to diagnostic and therapeutic problems associated with nasopharyngeal chordomas. Furthermore, it indicated the necessity for the accurate laryngological examination of patients with SDB.

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“…This study reviews CT and MR findings of 5 cases of chordomas with no clivus destruction in the nasal cavity or nasopharynx seen from 2004 to 2008 in our hospital, in an effort to improve the value of the differential imaging features of these unusual lesions. [20,21] One case of squamous cell carcinoma, two cases of olfactory neuroblastoma in mean age group of 51 years and these are uncommon malignant neoplasms, 2-3% of sinonasal tract tumors. Histologically, they are lobular in appearance with uniform round cells and neurofibrillary material and are graded 1-4 as per Hyam criteria.…”

Section: Discussionmentioning

confidence: 99%

To study the immunohistochemical profile of sinonasal and nasopharyngeal masses

Mukherjee

Roy

Mukherjee

et al. 2017

Int J Mol Immuno Oncol.

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This is a retrospective observational study of lesions and masses of sinonasal tract and nasopharynx which were received after incisional biopsy or surgical excision. The duration was from May 2011 to April 2016 a total of 5 years. The patients were evaluated on the basis of their chief complaints. Complete ENT examination which included nasal endoscopy and radiological evaluation was done. The study was carried out in collaboration with ENT and oncopathology department. Patient's feedback, clinical history and follow-up were done. Histopathology, microbiological culture, and isolates were also studied. Hematoxylin and eosin (H and E) sections were studied for histopathological review and lesions were subgrouped into non-neoplastic lesion, benign neoplasm, and malignant neoplasm categories. Depending on the morphology ABSTRACTIntroduction: Sinonasal and nasopharyngeal tract masses can be difficult to diagnose as they have unusual diverse morphology and histopathology with anatomic and embryonic distinction and immunohistochemistry (ICH) becomes mandatory for diagnosis. Aims and Objectives: A retrospective observational study of 5 years from 2011 to 2016 till date was conducted at a tertiary care center. Total analyses of 200 cases were done to study the clinical presentation and histomorphology of all sinonasal and nasopharyngeal masses with gender and age distribution and highlightling the entities with rare clinicopathological and histological presentation and study of ICH in these lesions. Results: Out of total 200 cases, 148 (74%) were inflammatory or infective non-tumorous masses and 52 (26%) were neoplastic, out of which 27 (13.5%) were benign and 25 (12.5%), were proven to be of malignant etiology. In benign neoplastic category, unusual entities were juvenile angiofibroma, meningioma, and hemangioma. Among the cases with atypical clinicopathological presentation and unusual entities which required ICH for diagnosis were chordoma, diffuse large B-cell lymphoma, esthesioneuroblastoma, sinonasal adenocarcinoma, adenoid cystic carcinoma, and nasopharyngeal carcinomas. Conclusion: Sinonasal and nasopharyngeal masses are having diverse clinical presentations at different sites having unusual clinical presentation and varied histopathology and the unusual varieties also occur which rare to these locations and should be promptly diagnosed with ICH for early, accurate and optimal treatment.

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Primary Chordoma in the Nasal Cavity and Nasopharynx: CT and MR Imaging Findings

Cited by 26 publications

References 23 publications

Unusual Presentation of Chordoma in Nose

Unusual Presentation of Chordoma in Nose

Nasopharyngeal chordoma in a patient with a severe form of sleep-disordered breathing: A case report

To study the immunohistochemical profile of sinonasal and nasopharyngeal masses

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