Cp50 of propofol with and without nitrous oxide 67%

Stuart, Pauline; Stott, S.; Millar, Audrey; Russell, D.

doi:10.1093/bja/84.5.638

Cited by 23 publications

(17 citation statements)

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“…They also added fentanyl 1-4 lg.ml )1 in these patients and investigated the reduction in the Cp50 levels produced by fentanyl. Two additional studies [4,5] reported levels of Cp50 of propofol for skin incision (Cp50incision). One of these studies used the TCI algorithm developed by Gepts et al [9]; the other study used Diprifusor TM .…”

Section: Discussionmentioning

confidence: 99%

“…There has been only one study, by Stuart et al [5], investigating the Cp50 of propofol and nitrous oxide using the Diprifusor TM , they reported the predicted level of Cp50incision (6.6 lg.ml…”

Section: Discussionmentioning

confidence: 99%

“…Nitrous oxide also has an analgesic effect and is often combined with propofol. There have been two reports of nitrous oxide reducing the concentration of Cp50 of propofol required for surgery [4,5], but there have been no similar reports during laryngeal mask airway insertion. However, it is known that nitrous oxide prevents movement during tracheal intubation with target-controlled infusion (TCI) of propofol [6].…”

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confidence: 99%

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Cp50 of propofol for laryngeal mask airway insertion using predicted concentrations with and without nitrous oxide

Kodaka

Handa²,

Kawasaki

et al. 2002

Anaesthesia

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SummaryThis study sought to determine the predicted Cp50 of propofol required for laryngeal mask airway insertion (Cp50LMA) and to investigate whether nitrous oxide reduces these required concentrations. Using target-controlled infusion and incorporating the standard Diprifusor TM pharmacokinetic model, 46 unpremedicated patients were randomly assigned to one of two groups. The patients received either 40% oxygen in air (control group: n ¼ 23), or 60% nitrous oxide in oxygen (nitrous oxide group: n ¼ 23). The target concentration for each patient was determined using the up and down method. Following equilibration between the predetermined blood and effect site concentrations, had been established for > 10 min, laryngeal mask airway insertion was attempted without neuromuscular relaxants. The data were analysed using a probit analysis to obtain Cp50LMA levels. The values for Cp50LMA were 3.24 lg.ml )1 in the control group and 1.93 lg.ml )1 in the nitrous oxide group.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Cp50 of propofol for laryngeal mask airway insertion using predicted concentrations with and without nitrous oxide

Kodaka

Handa²,

Kawasaki

et al. 2002

Anaesthesia

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“…Considering the model of the present study, the k e0 of propofol was estimated to be 0.46 min -1 corresponding to a time of peak effect concentration of 1.7 min [25][26]. Another study demonstrated that in the case of a single dose of propofol, peak effect concentration is obtained after about 4 min [31] while 80% of a final target concentration will be achieved at the effect site within about 6 min [32]. Wakeling et al [33] found that a k e0 of 0.63min -1 for propofol determined a loss of responsiveness in 1.23 min, and with a simulation they found that the desired effect site concentration was reached after 2 min.…”

Section: Discussionmentioning

confidence: 62%

Comparison of the qCON and qNOX indices for the assessment of unconsciousness level and noxious stimulation response during surgery

Melia¹,

Gabarron²,

Agustí

et al. 2016

J Clin Monit Comput

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Purpose. The objective of this work is to compare the behavior of two electroencephalogram (EEG) based indices after drug induction and during recovery of consciousness.Methods. Data was recorded from 140 patients scheduled for general anaesthesia with a combination of propofol and remifentanil. The qCON 2000 monitor (Quantium Medical, Barcelona, Spain) was used to calculate the qCON and qNOX. The fall times and the rise times were defined at the start and at the end of the surgery. Loss of response to verbal command and loss of eye-lash reflex were assessed during the transition from awake to anesthetized, defining the state of loss of consciousness (LOC). Movement as a response to laryngeal mask (LMA) insertion was interpreted as the response to the nociceptive stimuli. The patients were classified as movers or non-movers. The values of qCON and qNOX were statistically compared. Conclusion.The indices qCON and qNOX were able to detect differences between the times of actions of hypnotic and analgesic agents. The qCON showed faster decrease during induction while the qNOX showed a faster increase during recovery.

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“…In this study the new surgical stimulus was performed 3 minutes after the bolus injection of 20% of induction dose of propofol and the infusion rates were increased by 20% over the previous value. Previous studies have shown that the time required for plasmatic concentration equilibrium between blood and brain was 12 minutes (Stuart et al 2000). In this view, we could have waited more than 12 minutes for the new surgical stimulus and recording of parameters.…”

Section: Discussionmentioning

confidence: 99%

Total intravenous anaesthesia with propofol-racemic ketamine and propofol-S-ketamine: a comparative study and haemodynamic evaluation in dogs undergoing ovariohysterectomy

et al. 2008

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216Pesq. Vet. Bras. 28(4):216-222, abril 2008 RESUMO.-[Anestesia total intravenosa com propofolquetamina racêmica e propofol quetamina-S: estudo comparativo e avaliação hemodinâmica em cães submetidos à ovariohisterectomia.] A anestesia total intravenosa (TIVA) com propofol e quetamina proporciona um efeito muito satisfatório do ponto de vista clínico. Este estudo, cego e randomizado, comparou a indução e manutenção da anestesia com infusão contínua de propofolquetamina racêmica (PRK) e propofol-quetamina-S (PSK) em cães, e avaliou seus efeitos hemodinâmicos, metabó-licos e ventilatórios. Foram avaliadas sete cadelas em cada grupo, submetidas à ovariohisterectomia. A anestesia foi induzida no Grupo PRK, com propofol (4.0mg kg -1 ) e cetamina (2.0mg kg -1 ) por via intravenosa (i.v.), seguida de infusão contínua de propofol (dose inicial de 0.5mg kg -1 min -1 ) e cetamina racêmica(0.2mg kg -1 min -1 ) i.v. No Grupo PSK, a indução anestésica foi com propofol (4.0mg kg -1 ) e cetamina-S (1.0 mg kg -1 ) i.v., seguida de infusão contínua de propofol (dose inicial de 0,5mg kg -1 min -1 ) e Total intravenous anaesthesia (TIVA) with propofol and ketamine proved to be very satisfactory from a clinical point of view. This blind randomised controlled trial was designed to compare induction and maintenance of anaesthesia under continuous infusion of propofol-racemic ketamine (PRK) with that of propofol-S-ketamine (PSK) and evaluate their haemodynamic, metabolic and ventilatory effects. Seven female dogs undergoing ovariohysterectomy were involved in each group. Anaesthesia was induced: in Group PRK, with propofol (4.0mg kg -1 ) and racemic ketamine (2.0mg kg -1 ) intravenous (i.v.), followed by i.v. infusion of propofol (initial dose of 0.5mg kg -1 min -1 ) and racemic ketamine (0.2mg kg -1 min -1 ); in Group PSK, with propofol (4.0mg kg -1 ) and S-ketamine (1.0 mg kg 1 ) i.v., followed by i.v. infusion of propofol (initial dose of 0.5mg kg -1 min -1 ) and S-ketamine (0.1mg kg -1 min -1 ). Parameters were assessed before anaesthesia and in 6 time points after induction. In both groups, heart rate increased significantly at all time points. There was a slight decrease in systemic blood pressure, cardiac output and cardiac index in both groups. The systolic index decrease significantly and intense respiratory depression was observed in all groups, making assisted ventilation necessary. Total intravenous anaesthesia with propofol-racemic ketamine and propofol-S-ketamine 217 cetamina-S ( 0.1mg kg -1 min -1 ) i.v. Os parâmetros foram observados antes da anestesia e em seis momentos após a indução anestésica. Em ambos os grupos, a freqüência cardíaca elevouse significantemente em todos os momentos. Houve pequena redução na pressão arterial sistêmica, débito cardíaco e índice cardíaco. O índice sistólico apresentou redução significante e houve intensa depressão respirató-ria em ambos os grupos. A anestesia total intravenosa com a associação do propofol à cetamina racêmica ou à cetamina-S proporciona boa estabilidade hemodinâmic...

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Cp50 of propofol with and without nitrous oxide 67%

Cited by 23 publications

References 0 publications

Cp50 of propofol for laryngeal mask airway insertion using predicted concentrations with and without nitrous oxide

Cp50 of propofol for laryngeal mask airway insertion using predicted concentrations with and without nitrous oxide

Comparison of the qCON and qNOX indices for the assessment of unconsciousness level and noxious stimulation response during surgery

Total intravenous anaesthesia with propofol-racemic ketamine and propofol-S-ketamine: a comparative study and haemodynamic evaluation in dogs undergoing ovariohysterectomy

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