Cp50 of propofol for laryngeal mask airway insertion using predicted concentrations with and without nitrous oxide

Kodaka, Mitsuharu; Handa, F; Kawasaki, Jun; Miyao, Hideki

doi:10.1046/j.1365-2044.2002.02821.x

Cited by 14 publications

(10 citation statements)

References 14 publications

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“…We reported previously that the levels of propofol Cp 50 for cLMA insertion were estimated as 3.24 lg/mL [8]. This study showed almost identical results to those that we reported earlier for Cp 50 of cLMA.…”

Section: Discussionsupporting

confidence: 87%

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Propofol concentration requirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Classic type, with target-controlled infusion

Handa-Tsutsui

Kodaka

2005

Journal of Clinical Anesthesia

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Section: Discussionsupporting

confidence: 87%

“…Concentration of plasma 50% (Cp 50 ), the concentration at which there is a 50% chance that a patient will respond by moving, was estimated as 3.24 lg/mL for cLMA insertion [8].…”

Section: Introductionmentioning

confidence: 99%

Propofol concentration requirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Classic type, with target-controlled infusion

Handa-Tsutsui

Kodaka

2005

Journal of Clinical Anesthesia

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“…Casati et al [21] revealed that LMA insertion with the Diprifusor TCI system at target plasma concentration of 6 μg/mL with 95% success rate. Kodaka et al [22] studied the target concentration of propofol required to prevent movement in 50% (Cp50) of propofol for LMA insertion, and calculated that the Cp50 for LMA insertion was 4.07 μg/mL. When the plasma concentration is targeted, the TCI machine will rapidly infuse propofol to increase the plasma concentration of propofol to the selected level.…”

Section: Discussionmentioning

confidence: 99%

“…The 178 K. Sintavanuruk, et al Schnider pharmacokinetic effective site TCI model [10] was found to have better speed of induction and hemodynamic stability than plasma target model [11,12]. Several studies demonstrated induction of anesthesia with different plasma target controlled infusion of propofol for LMA insertion [13][14][15]. However, there is no study to compare the standard bolus propofol induction with the effective site TCI for LMA insertion.…”

mentioning

confidence: 99%

Comparative study of effective-site target controlled infusion with standard bolus induction of propofol for laryngeal mask airway insertion

et al. 2010

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Background:The laryngeal mask airway (LMA) is widely used in emergency medicine and surgical anesthesia. Several studies demonstrated induction of anesthesia with different plasma target-controlled infusion (TCI) of propofol for LMA insertion. However, there has been no study to compare the standard bolus propofol induction with the effective site TCI for LMA insertion. Objective: Compare the efficacy of induction of anesthesia with propofol for LMA insertion between the effective-site TCI, using 6 μg/mL, and the standard bolus propofol dose of 2.5 mg/kg in elective surgical patients. Methods: A randomized, prospective, single-blinded, clinical study was used for this study. Seventy-eight unpremedicated patients, American Society of Anesthesiologists (ASA) physical status I and II undergoing elective surgical procedure were randomly allocated between two groups. Group 1 received the standard bolus propofol dose of 2.5 mg/kg. Group 2 received effective site TCI (Schnider model) dose of 6 μg/mL for LMA insertion. The hemodynamics and anesthetic depth (Bispectral index score) were monitored and recorded during and immediately after LMA insertion. The number of insertion attempted, insertion quality score, induction time, and propofol doses used were recorded and compared between groups. Results: The success rate of first insertion attempt was equal in both groups (92.3%). There was no significant hemodynamic response difference between the groups during pre-induction, induction, insertion, and post insertion period. The BIS score was significantly lower during post insertion period in group 1 (51.4+11.0) than group 2 (58.4+3.2) (p=0.013). The propofol doses in group 2 were significantly lower than in group 1 (110.6+14.8 vs. 153.5+21.5) (p <0.001). Patients in group 2 required significantly more induction time than group 1 (146.9+42.3 vs. 103.4+33.6 (p <0.001). Conclusion: Propofol induction with TCI provided equal success rate as compared with standard bolus propofol induction for LMA insertion and insertion quality score. TCI significantly lowered the propofol consumption when compared with the standard 2.5 mg/kg propofol dose.

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“…However, the ED 95 is probably more relevant than the ED 50 in our current study, as patients need to be adequately anaesthetised for laryngeal mask airway insertion. We estimated ED 95 by simple extrapolation of the logistic regression curve, which resulted in larger confidence intervals [17].…”

Section: Discussionmentioning

confidence: 99%

The optimum bolus dose of remifentanil to facilitate laryngeal mask airway insertion with a single standard dose of propofol at induction in children

Kwak

Kim

et al. 2008

Anaesthesia

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SummaryThe purpose of this study was to determine the optimal bolus dose of remifentanil required for the successful insertion of the laryngeal mask airway during propofol induction in children without a neuromuscular blocking agent. Twenty-six paediatric patients, aged 3-10 years, requiring anaesthesia for short ambulatory surgery were recruited. A predetermined bolus dose of remifentanil was injected over 30 s, followed by propofol 2.5 mg.kg )1 over 10 s. The bolus dose of remifentanil was determined by a modified Dixon's up-and-down method, starting from 0.5 lg.kg )1(0.1 lg.kg )1 as a step size). Laryngeal mask insertion was attempted 90 s after the end of remifentanil injection and the response of patients was classified as either 'movement' or 'no movement'. The bolus dose of remifentanil at which there was a 50% probability of successful laryngeal mask insertion (ED 50 ) during induction with 2.5 mg. ), respectively.

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Cp50 of propofol for laryngeal mask airway insertion using predicted concentrations with and without nitrous oxide

Cited by 14 publications

References 14 publications

Propofol concentration requirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Classic type, with target-controlled infusion

Propofol concentration requirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Classic type, with target-controlled infusion

Comparative study of effective-site target controlled infusion with standard bolus induction of propofol for laryngeal mask airway insertion

The optimum bolus dose of remifentanil to facilitate laryngeal mask airway insertion with a single standard dose of propofol at induction in children

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