Coxiella symbiont in the tick Ornithodoros rostratus (Acari: Argasidae)

Almeida, Arlindo; Marcili, Arlei; Leite, Romário Cerqueira; Nieri-Bastos, Fernanda A.; Domingues, Luísa N.; Martins, João Ricardo; Labruna, Marcelo Bahia

doi:10.1016/j.ttbdis.2012.02.003

Cited by 129 publications

(116 citation statements)

References 22 publications

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“…The diversity of microbial communities has been characterized in different ticks (16)(17)(18)(19)(20)(21). The effect of tick microbiota on the transmission of human infectious diseases, and the molecular mechanisms underlying these processes, has only recently received attention.…”

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confidence: 99%

Pathogen-mediated manipulation of arthropod microbiota to promote infection

Abraham

Liu

Jutras

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

219

295

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Arthropods transmit diverse infectious agents; however, the ways microbes influence their vector to enhance colonization are poorly understood.Ixodes scapularisticks harbor numerous human pathogens, includingAnaplasma phagocytophilum,the agent of human granulocytic anaplasmosis. We now demonstrate thatA. phagocytophilummodifies theI. scapularismicrobiota to more efficiently infect the tick.A. phagocytophiluminduces ticks to expressIxodes scapularisantifreeze glycoprotein (iafgp), which encodes a protein with several properties, including the ability to alter bacterial biofilm formation. IAFGP thereby perturbs the tick gut microbiota, which influences the integrity of the peritrophic matrix and gut barrier—critical obstacles forAnaplasmacolonization. Mechanistically, IAFGP binds the terminald-alanine residue of the pentapeptide chain of bacterial peptidoglycan, resulting in altered permeability and the capacity of bacteria to form biofilms. These data elucidate the molecular mechanisms by which a human pathogen appropriates an arthropod antibacterial protein to alter the gut microbiota and more effectively colonize the vector.

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mentioning

confidence: 99%

Pathogen-mediated manipulation of arthropod microbiota to promote infection

Abraham

Liu

Jutras

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

219

295

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“…To date, various Coxiella-like microorganisms have been detected in both hard and soft ticks (21,32,33,34,35,36,37,38). Interestingly, Coxiella-like microorganisms exhibited diverse 16S rRNA genotypes from different tick species.…”

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confidence: 99%

Coinfection of Dermacentor silvarum Olenev (Acari: Ixodidae) by Coxiella-Like, Arsenophonus-Like, and Rickettsia-Like Symbionts

Liu

et al. 2013

Appl Environ Microbiol

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“…For the Coxiella genus, the species C. burnetii is mostly considered as a vertebrate pathogen while numerous other Coxiella species have been found associated to ticks [41]. Phylogenetic analyses combined with future science group www.futuremedicine.com experimental approaches suggested that these might also be considered as endosymbionts of ticks [11,42]. Thus, the pathogenic nature of C. burnetii could be an exception within the genus [43].…”

Section: The Technology-driven Revolution Of Tickborne Pathogen's Vismentioning

confidence: 99%

Emerging Horizons for Tick-Borne Pathogens: From the ‘One Pathogen–one Disease’ Vision to the Pathobiome Paradigm

et al. 2015

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Ticks, as vectors of several notorious zoonotic pathogens, represent an important and increasing threat for human and animal health in Europe. Recent applications of new technology revealed the complexity of the tick microbiome, which may affect its vectorial capacity. Appreciation of these complex systems is expanding our understanding of tick-borne pathogens, leading us to evolve a more integrated view that embraces the 'pathobiome'; the pathogenic agent integrated within its abiotic and biotic environments. In this review, we will explore how this new vision will revolutionize our understanding of tickborne diseases. We will discuss the implications in terms of future research approaches that will enable us to efficiently prevent and control the threat posed by ticks.

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Coxiella symbiont in the tick Ornithodoros rostratus (Acari: Argasidae)

Cited by 129 publications

References 22 publications

Pathogen-mediated manipulation of arthropod microbiota to promote infection

Pathogen-mediated manipulation of arthropod microbiota to promote infection

Coinfection of Dermacentor silvarum Olenev (Acari: Ixodidae) by Coxiella-Like, Arsenophonus-Like, and Rickettsia-Like Symbionts

Emerging Horizons for Tick-Borne Pathogens: From the ‘One Pathogen–one Disease’ Vision to the Pathobiome Paradigm

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