Cow’s Milk Allergy in Infants and Children

Clinical and Immunological Aspects of Milk Protein Intolerance

“…Milk allergy is almost invariably a selflimited condition lasting at the most 2 years and usually less (Collins-Williams, 1962).…”

“…Once dietetic treatment has been initiated the prognosis is excellent. Milk allergy usually disappears spontaneously within 1 to 2 years (Collins-Williams, 1962). Fatalities or near fatalities still occur.…”

Cows' milk allergy in the syndrome of thrombocytopenia with absent radius.

“…There are many similarities in clinical course and laboratory data between these 17 cases and the severe gastrointestinal type of cows' milk allergy, as illustrated in the Table. Full details of gastrointestinal investigation are not available for the majority of the 17 cases. In spite of the apparent similarity of the two conditions none of the reviews of cows' milk allergy make any reference to TAR (Clein, 1954;Dees, 1959;Stanfield, 1959;Collins-Williams, 1962;Heiner, Wilson, and Lahey, 1964;Kletter, 1970, 1972;Gerrard et al, 1973;Walker-Smith, 1975). This may be explained by the relative rarity of TAR cases, only a proportion of which may show recognizable features of cows' milk allergy.…”

“…No evidence of pancreatic insufficiency was found in a case of TAR investigated by Masson et al (1971). (Gerrard et al, 1967) Waning of sensitivity to cows' milk between 3 months (Stanfield, 1959) and 3j years (Gerrard, 1967); 80% of Clein's series (1958) could tolerate cows' milk by age 1 year Frequently occurring features of cows' milk allergy (Clein, 1954: Stanfield, 1959Collins-Williams, 1962;Kletter, 1970, 1972) Recognized complications of acute cows' milk allergy (Freier and Kletter, 1972;Kuitunen et al, 1975) 100% Common feature of cows' milk allergy (Freier and Kletter, 1970;Wilson et al, 1964) Reversible changes found in cows' milk allergy (Silver and Douglas, 1968;Gryboski et al, 1966;Gryboski, 1967) As noted by Tonz et al (1960) the degree and rapidity of progression of the anaemia appears to be out of proportion to the degree of haemorrhage in some cases. This is true of our case and though a haemolytic element has been suggested in some cases no uniform extraor intracorpuscular or vascular cause has ever been delineated (Hall et al, 1969).…”

Milk‐induced Colitis

“…One group consists of "usual" allergic symptoms, for instance eczema, urticaria, rhinitis and asthma. These symptoms often disappear when milk is withdrawn from the food and reappear on reintroduction of the milk (2,10).…”