Clinical and Immunological Aspects of Milk Protein Intolerance

Food Protein-induced Enterocolitis: Altered Antibody Response to Ingested Antigen

“…One could not therefore reliably predict challenge outcome based solely on antibody titer . These results are in disagreement with some studies in which predictive value of antibodies is suggested (8,18,29) but confirm the considerable overlap of data found in other studies (1,6,23).…”

“…Sensitization of T lymphocytes to cow milk -antigens has been described in milk-sensitive infants (3). In addition, in some studies, increased serum antibodies to food proteins were thought to correlate with positive responses to oral cow milk challenge (8,18,29). However, in other studies, no difference in serum antibodies was found between milk-sensitive and normal infants (1,6,23).…”

Cows' milk allergy in the syndrome of thrombocytopenia with absent radius.

“…Nutramigen produced no gastrointestinal relapse in our patient but did induce a temporary haematological upset (see below). Both gastrointestinal blood loss and a clinical pattern of apparent intestinal obstruction are recognized complications of cows' milk allergy (Freier and Kletter, 1972). The histological appearances of the colonic biopsy taken after 15 days of cows' milk feeding agree with the reversible pattern described by Gryboski, Burkle, and Hillman, 1966) and Silver and Douglas (1968) in milk allergic subjects.…”

“…A diagnosis of cows' milk allergy is reached on clinical grounds with supportive laboratory evidence. The diagnostic criteria of Goldman et al (1963) are accepted as proof of a firm diagnosis of cows' milk allergy (Freier and Kletter, 1972;Gerrard et al, 1967), though Walker-Smith (1975) has considered these criteria to be too rigid. In our case elimination of dried cows' milk formula from the diet on three occasions, because of worsening gastrointestinal symptoms while on cows' milk feeds, at 21 days, 41 days, and 62 days of life, resulted in rapid and sustained reduction in gastrointestinal symptoms within 48 hours on each occasion (Fig.…”

Sugar-induced diarrhoea in children.

“…It must be borne in mind, of course, that patients with cow's milk protein allergy will respond in the same way since lactose-free diets are usually free of milk-protein as well. These patients can be differentiated by their responses to separate milk protein fractions and lactose (Freier and Kletter, 1972). Temporary histological changes and generalized depression of disaccharidase activity occur in secondary lactose intolerance, but these are not specific and are not needed to reach the diagnosis.…”