COVID-19 vaccine-associated ganulomatous mass mimicking a sarcoma: a case report

Quintero, Daniel; Patel, Nikhil; Harris, Griffin; Maristany, Anthony; Al-Ani, Ali; Rosenberg, Andrew E.; Conway, Sheila; Jose, Jean

doi:10.1016/j.radcr.2022.05.035

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…Aluminum salt adjuvants used in the pertussis vaccine produced an inflammatory granulomatous response in up to 77% of children [ 20 ]. To date, there have been only two cases reporting inflammatory granulomatous reactions resulting in pseudo-tumors after receiving COVID-19 vaccines [ 7 , 8 ]. The first case discussed a granulomatous soft tissue mass at the injection site following the Moderna booster dose [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…To date, there have been only two cases reporting inflammatory granulomatous reactions resulting in pseudo-tumors after receiving COVID-19 vaccines [ 7 , 8 ]. The first case discussed a granulomatous soft tissue mass at the injection site following the Moderna booster dose [ 7 ]. The soft tissue mass mimicking sarcoma presented similarly on histology but resolved spontaneously [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The first case discussed a granulomatous soft tissue mass at the injection site following the Moderna booster dose [ 7 ]. The soft tissue mass mimicking sarcoma presented similarly on histology but resolved spontaneously [ 7 ]. Interestingly, there have been reports of the Moderna vaccine being associated with malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…As the number of vaccines administered continues to increase, so do reports of hypersensitivity reactions, which have been attributed to vaccine ingredients and injection techniques [ 2 , 6 ]. To our knowledge, there have only been two prior reports of granulomatous soft tissue mass (pseudo-tumor) reactions following COVID-19 vaccination [ 7 , 8 ]. We present a case of a patient who recognized a mass in the proximal-medial short head of the right biceps six months after receiving a booster dose of the Moderna vaccine.…”

Section: Introductionmentioning

confidence: 99%

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Right Biceps Pseudo-Tumor from COVID-19 Vaccination

Abbas,

Caicedo,

Damron

2024

Vaccines

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Delayed hypersensitivity reactions (DHRs) have been reported in association with COVID-19 vaccines, particularly those that are mRNA-based. Classic DHRs result in induration, erythema, tenderness, and urticaria. However, soft tissue mass is an uncommon complication of a COVID-19 vaccination-associated DHR and is rarely reported in the literature. We present a case of a 49-year-old male who recognized a mildly painful, firm soft tissue mass within the biceps mimicking neoplasm six months after receiving the booster dose of the Moderna vaccine. Non-operative conservative treatment modalities, including heating pads, ice packs, acetaminophen, and ibuprofen, failed to improve the patient’s mass. The mass, which proved histologically to be an inflammatory pseudo-tumor, did not recur after complete excision. While there have been many reported cases of DHRs following COVID-19 vaccinations, we present this case to raise awareness of the development of pseudo-tumors as a possible, yet rare, clinical manifestation of DHRs following vaccination.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Right Biceps Pseudo-Tumor from COVID-19 Vaccination

Abbas,

Caicedo,

Damron

2024

Vaccines

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“…Pathological analysis subsequently demonstrated non-necrotizing granulomatous inflammation without evidence of neoplasia. This case reported the development of a localized granulomatous reaction that presented as a mass following the COVID-19 Moderna booster vaccine that resolved spontaneously without any medical intervention [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Development of High-Grade Sarcoma After Second Dose of Moderna Vaccine

Bae¹,

Bae²,

Vays³

et al. 2023

Cureus

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Coronavirus disease 2019 (COVID-19) is a disease characterized by predominantly respiratory symptoms, which can progress to respiratory failure. Due to the novelty of the vaccines, it is difficult to assess if there are any associated long-term side effects. Here, we present a case of an elderly female who received the Moderna COVID-19 vaccine and developed a high-grade sarcoma at the site of the injection. A 73-year-old female with a past medical history of hypertension, hyperlipidemia, and renal angiomyolipoma status post resection in 2019 presented with worsening right upper arm swelling for the past two weeks. She noticed the swelling two to four days after receiving her second dose of the Moderna vaccine within 1 cm from the prior injection site. Physical examination was remarkable for a 6 cm, circular, mobile, soft mass present in the right upper arm. MRI with and without contrast revealed a 5.2 cm soft tissue mass overlying the triceps region with irregular features concerning for malignancy. Fine needle aspiration revealed pathologic characteristics indicative of high-grade sarcoma. The patient ultimately had resection of the mass four months after the initial visit and was diagnosed as having grade 3, stage IIIA undifferentiated, pleomorphic high-grade sarcoma. Herein, we present a case demonstrating the development of high-grade sarcoma at the injection site in an elderly female patient within days of receiving the second dose of the Moderna COVID-19 vaccine. Currently, it is unclear whether there is a true association between the vaccines and malignancy or inflammatory response exacerbating underlying malignancy. This case highlights the necessity to investigate and be aware of such rare, adverse complications that may be associated with the novel COVID-19 vaccinations to guide physicians in their differential diagnosis.

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Complications After Exosome Treatment for Aesthetic Skin Rejuvenation

Nahm,

Thunga,

Yoo

2024

Dermatological Reviews

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BackgroundExosomes have gained significant attention in aesthetic dermatology for their potential in skin rejuvenation. Despite numerous studies investigating the use of exosomes in aesthetic applications, no adverse events have been reported thus far. This case series presents patients with noticeable adverse effects following the application of exosomes to the skin for aesthetic purposes in South Korea.MethodsA consortium of concerned aesthetic dermatologists from South Korea provided a case series of patients who developed complications after receiving exosome treatments for skin rejuvenation. The case series included eight female patients, ranging in age from 26 to 52 years old, who developed delayed‐onset granulomatous lesions at the treatment sites.ResultsAll patients in the case series developed erythematous, indurated papules or nodules at the sites of exosome injections, with onset ranging from 2 weeks to 3 months posttreatment. Histopathological examination of biopsied lesions revealed necrotizing granulomas not related to mycobacterial infections. The patients' response to topical and oral steroids, as well as other treatments, varied.ConclusionAlthough exosome‐based therapies hold great promise in aesthetic dermatology, this case series highlights the potential for delayed‐onset granulomatous complications following exosome treatments for skin rejuvenation. Standardized protocols for exosome isolation and purification, as well as rigorous safety and efficacy standards, are needed to ensure the successful implementation of exosome‐based products in clinical settings.

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COVID-19 vaccine-associated ganulomatous mass mimicking a sarcoma: a case report

Cited by 5 publications

References 15 publications

Right Biceps Pseudo-Tumor from COVID-19 Vaccination

Right Biceps Pseudo-Tumor from COVID-19 Vaccination

Development of High-Grade Sarcoma After Second Dose of Moderna Vaccine

Complications After Exosome Treatment for Aesthetic Skin Rejuvenation

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