COVID-19 Vaccination Willingness and Hesitancy in Patients With Inflammatory Bowel Diseases: Analysis of Determinants in a National Survey of the Italian IBD Patients’ Association

Costantino, Andrea; Noviello, Daniele; Conforti, Francesco; Aloi, Marina; Armuzzi, Alessandro; Bossa, Fabrizio; Ficari, Ferdinando; Leone, Salvatore; Manguso, Francesco; Mocci, Giammarco; Orlando, Ambrogio; Pironi, Loris; Radice, Simona; Rizzello, Fernando; Tongiorgi, A.; Costantino, Claudio; Vecchi, Maurizio; Caprioli, Flavio

doi:10.1093/ibd/izab172

Cited by 29 publications

(26 citation statements)

References 9 publications

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“…However, only 11% of the participants took the vaccine in our study, which was significantly lower than the national average uptake (3). This acceptance was also significantly lower than the data of Italian patients living with inflammatory bowel disease (80.3%) (18) and celiac disease (74.8%) (19). On one hand, the acceptance in our study referred to the rate of patients who had already received the vaccine, which might be lower than the rate of willingness.…”

Section: Discussioncontrasting

confidence: 89%

A Survey of Hesitancy and Response to the COVID-19 Vaccine Among Patients With Epilepsy in Northeast China

Chu

Lin

2021

Front. Neurol.

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Objective: This study was conducted to investigate the hesitancy and response of people with epilepsy (PWE) to the coronavirus disease 2019 (COVID-19) vaccine.Methods: We conducted an online survey among PWE in northeast China about hesitancy and response to the COVID-19 vaccine. Their demographic background and symptomatic data about epilepsy were also recorded, and we analyzed the epilepsy-related risk factors in delaying the vaccine.Results: In total, 357 patients with confirmed epilepsy were included in the survey, and only 38 (11%) patients received the COVID-19 vaccine. Fear of aggravating epilepsy (58%, n = 185), discouragement from health workers for epilepsy (22%, n = 70), and fear of patients of other unknown serious side effects (13%, n = 42) were the main reasons for delaying vaccination. A higher seizure frequency was the only epilepsy-related risk factor in delaying the vaccine (OR = 1.104, 95% CI: 0.988–1.233). None of the vaccinated patients reported that the vaccine aggravated their epilepsy.Significance: Understanding concerns about the COVID-19 vaccine among PWE could help to improve health education and promote the establishment of an immune barrier.

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Section: Discussioncontrasting

confidence: 89%

A Survey of Hesitancy and Response to the COVID-19 Vaccine Among Patients With Epilepsy in Northeast China

Chu

Lin

2021

Front. Neurol.

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“…It was reported that 67.1% of the general population in China were willing to accept the COVID-19 vaccination during the same period (22). Furthermore, the rate of vaccination intent among IBD participants in our present study was lower than that among the IBD population in Boston (80.9%) (23) and Italy (80.3%) (24). Similarly, a lower rate of intent for hepatitis B (18.8%) and varicella vaccines (6.6%) was observed among patients with IBD in China (25).…”

Section: Discussioncontrasting

confidence: 67%

“…In the present study, COVID-19 vaccination hesitancy existed in 50.7% of patients with IBD and merely 16.0% of participants opted for vaccination (Figure 1). The attitude of the participants towards the COVID-19 vaccine was significantly more negative than that of the general population in China and the patients with IBD from other countries (22)(23)(24). It was reported that 67.1% of the general population in China were willing to accept the COVID-19 vaccination during the same period (22).…”

Section: Discussionmentioning

confidence: 98%

The COVID-19 Vaccination Hesitancy Among the People With Inflammatory Bowel Disease in China: A Questionnaire Study

Lin

Buch

et al. 2021

Front. Public Health

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Objective: To explore the attitudes and views of patients with inflammatory bowel disease (IBD) on COVID-19 vaccination.Methods: An online interview questionnaire concerning the acceptance or hesitancy toward vaccination for COVID-19 was designed and 543 patients with IBD in China were invited to complete the structured self-administered anonymous questionnaire.Results: Of all the participants, 50.7% were indecisive about the vaccination and only 16.0% opted for it. Vaccination hesitancy was significantly associated with women and those without medical or biomedical backgrounds. The acceptance of COVID-19 vaccination was higher in participants with no history of immune-modifying therapies, especially in those without immunosuppressants. Participants who considered vaccination critically important to self-health or the health of others were more likely to choose immediately or later vaccination. Safety and potential adverse reactions, personal hypoimmunity, efficacy, and reliability of COVID-19 vaccines were the top three concerns of the participants that were independent of their willingness for vaccination.Conclusions: This study discloses the presence of hesitancy for COVID-19 vaccination in patients with IBD. Further studies are warranted to evaluate the efficacy and safety of COVID-19 vaccines in IBD individuals, with a specific focus on the impact of immune-modifying therapies. Health education and recommendation from authoritative sources may facilitate COVID-19 vaccination efforts.

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“…The delta variant had a prevalence ranging from 5.2% in May to 77.7% at the end of July 2021 [20]. The vaccination hesitancy in our LT patients was not correlated with immunosuppressive drugs, as observed in a large national cohort of patients with inflammatory bowel diseases [21]. As a limitation of our study, we did not investigate whether patients' residence distance from the vaccine center might have influenced vaccination hesitancy.…”

Section: Discussionmentioning

confidence: 90%

COVID-19 Vaccine Acceptance among Liver Transplant Recipients

et al. 2021

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(1) Background: COVID-19 vaccination hesitancy is a threat for fragile patients. We aimed to evaluate COVID-19 vaccination hesitancy and its reasons in a population of liver transplant (LT) recipients. (2) Methods: In February 2021, a questionnaire on COVID-19 vaccines was sent to LT patients followed at our liver transplant outpatient clinic in Milan, Italy. Sociodemographic and clinical characteristics were recorded. Patients were defined as willing, hesitant, or refusing and their reasons were investigated. Associations between baseline characteristics and willingness were evaluated. Since March 2021, when the COVID-19 vaccines became available for LT candidates and recipients in Italy, the entire cohort of LT recipients was contacted by phone and called for vaccination, and the rate of refusals recorded. (3) Results: The web-based survey was sent to 583 patients, of whom 190 responded (response rate of 32.6%). Among the respondents to the specific question about hesitancy (184), 157 (85.3%) were willing to be vaccinated against COVID-19, while 27 (14.7%) were hesitant. Among the hesitant, three were totally refusing, for a refusal rate of 1.6%. Thirteen hesitant patients (48.1%) answered that their COVID-19 vaccination hesitancy was influenced by being a transplant recipient. The fear of adverse effects was the main reason for refusal (81.5%). Of the 711 LT patients followed at our center, 668 got fully vaccinated, while 43 (6.1%) of them refused the scheduled vaccination. (4) Conclusions: Most patients accepted COVID-19 vaccines, although 6.1% refused the vaccine. Since it is crucial to achieve adequate vaccination of LT patients, it is very important to identify the reasons influencing COVID-19 vaccination hesitancy so that appropriate and targeted communication strategies can be established and specific vaccination campaigns further implemented.

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COVID-19 Vaccination Willingness and Hesitancy in Patients With Inflammatory Bowel Diseases: Analysis of Determinants in a National Survey of the Italian IBD Patients’ Association

Cited by 29 publications

References 9 publications

A Survey of Hesitancy and Response to the COVID-19 Vaccine Among Patients With Epilepsy in Northeast China

A Survey of Hesitancy and Response to the COVID-19 Vaccine Among Patients With Epilepsy in Northeast China

The COVID-19 Vaccination Hesitancy Among the People With Inflammatory Bowel Disease in China: A Questionnaire Study

COVID-19 Vaccine Acceptance among Liver Transplant Recipients

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