COVID-19 Therapy: Could a Chlorophyll Derivative Promote Cellular Accumulation of Zn2+ Ions to Inhibit SARS-CoV-2 RNA Synthesis?

Clark, Nicole F; Taylor‐Robinson, Andrew W.

doi:10.3389/fpls.2020.01270

Cited by 9 publications

(7 citation statements)

References 29 publications

(93 reference statements)

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“…It is interesting that Pba (or highly related compounds such as pyroPba) has been isolated from different plant species and different organisms, including marine algae ( 38 ), rendering Pba a very attractive antiviral due to its high availability. Moreover, it has been postulated that Pba can transport a metal ion like zinc inside the cell and that zinc can inhibit viral replication ( 39 ), which might be another advantage to using these molecules as antivirals. In our study, it was confirmed that neither natural nor commercial Pba used in our experiments contained a metal ion, so future studies should be performed with zinc Pba to demonstrate this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses

Meunier

Desmarets

Bordage

et al. 2022

Antimicrob Agents Chemother

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The SARS-CoV-2 outbreak has highlighted the need for broad-spectrum antivirals against coronaviruses (CoVs). Here, pheophorbide a (Pba) was identified as a highly active antiviral molecule against HCoV-229E after bioguided fractionation of plant extracts. The antiviral activity of Pba was subsequently shown for SARS-CoV-2 and MERS-CoV, and its mechanism of action was further assessed, showing that Pba is an inhibitor of coronavirus entry by directly targeting the viral particle. Interestingly, the antiviral activity of Pba depends on light exposure, and Pba was shown to inhibit virus-cell fusion by stiffening the viral membrane as demonstrated by cryo-electron microscopy. Moreover, Pba was shown to be broadly active against several other enveloped viruses, and reduced SARS-CoV-2 and MERS-CoV replication in primary human bronchial epithelial cells. Pba is the first described natural antiviral against SARS-CoV-2 with direct photosensitive virucidal activity that holds potential for COVID-19 therapy or disinfection of SARS-CoV-2 contaminated surfaces.

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Section: Discussionmentioning

confidence: 99%

A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses

Meunier

Desmarets

Bordage

et al. 2022

Antimicrob Agents Chemother

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“…Furthermore, organometallic compounds such as sodium copper chlorophyllin synthesized from chlorophyll show antibacterial and antiviral activity [113] , [114] . An enhanced level of antiviral activities can be achieved using nanomaterials, as discussed in the next section.…”

Section: Antiviral Strategies Against Coronavirusesmentioning

confidence: 99%

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

Seifi

Kamali

2021

Medicine in Drug Discovery

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Coronavirus disease-2019 has been one of the most challenging global epidemics of modern times with a large number of casualties combined with economic hardships across the world. Considering that there is still no definitive cure for the recent viral crisis, this article provides a review of nanomaterials with antiviral activity, with an emphasis on graphene and its derivatives, including graphene oxide, reduced graphene oxide and graphene quantum dots. The possible interactions between surfaces of such nanostructured materials with coronaviruses are discussed. The antiviral mechanisms of graphene materials can be related to events such as the inactivation of virus and/or the host cell receptor, electrostatic trapping and physico-chemical destruction of viral species. These effects can be enhanced by functionalization and/or decoration of carbons with species that enhances graphene-virus interactions. The low-cost and large-scale preparation of graphene materials with enhanced antiviral performances is an interesting research-direction to be explored.

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“…58 Chlorophyll derivatives have proven antiviral activity against SARS-CoV-2 virus. 59 Chlorophyll A absorbs light in the violet-blue region (430-450 nm) and is a type II PI that can initiate the free radical photopolymerization of methyl methacrylate, to produce cross-linked polymethyl methacrylate. 60…”

Section: Chlorophyllsmentioning

confidence: 99%

Naturally Derived Photoinitiators for Dental and Biomaterials Applications

Abdul-Monem

2020

European Dental Research and Biomaterials Journal

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Biocompatibility of materials used in dental and biomaterials applications is very important and depends on the components of these materials. Photopolymerized materials for dental and biomaterials applications have been progressively used since the 1970s. One of the crucial components in these materials is the photoinitiator (PI) that initiates the polymerization reaction. Synthetic PIs are the most commonly used types, but owing to their drawbacks such as cytotoxicity, insolubility in water, and high cost, research on naturally derived (bio-sourced) PIs is growing, to find an alternative to these synthetic types, especially in the growing field of three-dimensional (3D) printing and bioprinting of biomaterials for tissue engineering applications. Naturally derived PIs are biocompatible, highly water-soluble, and abundant. Naturally derived PIs have been used to prepare experimental dentine bonding agents, dentine primers, photo-crosslinked hydrogels for tissue engineering applications, antibacterial coatings, guided tissue regeneration membranes, and 3D printed biomaterials. An electronic search was done using MEDLINE/PubMed and Scopus databases using the keywords naturally derived, bio-sourced, PIs, dental, biomaterials, 3D printing, and 3D bioprinting, to review potential naturally derived PIs for dental and biomaterials applications. There are a variety of naturally derived PIs with various colors and absorption spectra to choose from, according to the intended application. Most of naturally derived PIs can be used with modern conventional dental light curing units, making them applicable for experimental studies for potential dental and biomaterials applications. Due to their biocompatibility and availability it is expected that in the upcoming years, research on naturally derived PIs and their dental and biomaterials applications will increase especially in the growing field of 3D bioprinting in which cell viability is essential; thus this review was done.

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COVID-19 Therapy: Could a Chlorophyll Derivative Promote Cellular Accumulation of Zn2+ Ions to Inhibit SARS-CoV-2 RNA Synthesis?

Cited by 9 publications

References 29 publications

A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses

A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

Naturally Derived Photoinitiators for Dental and Biomaterials Applications

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