COVID-19: The Conjunction of Events Leading to the Coronavirus Pandemic and Lessons to Learn for Future Threats

Frutos, Roger; Roig, María Cols; Serra‐Cobo, Jordi; Devaux, Christian

doi:10.3389/fmed.2020.00223

Cited by 58 publications

(71 citation statements)

References 28 publications

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“…contacts, land conversion, markets, international trades, mobility, etc. ( Pike et al, 2010 ; Frutos et al, 2020 ). A major positive effect of the circulation model is that the focus is put on these human activities and not on wildlife.…”

Section: Resultsmentioning

confidence: 99%

“…It appears to only be a parallel host infected by a Sarbecovirus very closely related to SARS-CoV-2 with whom it shares a common ancestor. Furthermore, the COVID-19 epidemic did not start in December 2019 in the Huanan Seafood Wholesale Market (HSWM) where pangolins were supposed to be sold but earlier and outside HSWM ( Frutos et al, 2020 ). Another conclusion is that very closely related Sarbecoviruses circulate in different hosts worldwide raising the question of the dynamic of zoonotic emergence and the role played by wildlife.…”

Section: Mainmentioning

confidence: 99%

“…In this model, the virus is developing into an epizootic stage in an animal population, reaching the threshold needed for interspecies transmission and following contact with humans, develop within the human populations. Socio-economic factors and demographic dynamic trigger the epidemic or pandemic expansion of the disease ( Plowright et al, 2017 ; Frutos et al, 2020 ). According to the spillover model, the disease already exists as an epizootic and, thus, identifying the animal reservoir is essential to stop viral spread.…”

Section: Mainmentioning

confidence: 99%

See 2 more Smart Citations

COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans

Frutos

Serra‐Cobo

Chen

et al. 2020

Infection, Genetics and Evolution

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The emergence of COVID-19 has triggered many works aiming at identifying the animal intermediate potentially involved in the transmission of SARS-CoV-2 to humans. The presence of SARS-CoV-2-related viruses in Malayan pangolins, in silico analysis of the ACE2 receptor polymorphism and sequence similarities between the Receptor Binding Domain (RBD) of the spike proteins of pangolin and human Sarbecoviruses led to the proposal of pangolin as intermediary. However, the binding affinity of the pangolin ACE2 receptor for SARS-CoV-2 RBD was later on reported to be low. Here, we provide evidence that the pangolin is not the intermediate animal at the origin of the human pandemic. Moreover, data available do not fit with the spillover model currently proposed for zoonotic emergence which is thus unlikely to account for this outbreak. We propose a different model to explain how SARS-CoV-2 related coronaviruses could have circulated in different species, including humans, before the emergence of COVID-19.

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Section: Resultsmentioning

confidence: 99%

Section: Mainmentioning

confidence: 99%

Section: Mainmentioning

confidence: 99%

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COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans

Frutos

Serra‐Cobo

Chen

et al. 2020

Infection, Genetics and Evolution

Self Cite

View full text Add to dashboard Cite

show abstract

“…The all-encompassing nature of the COVID-19 pandemic has prompted much reflection (e.g., Chin et al, 2020 ), as scholars gather their thoughts to decipher lessons for the future. Many such articles focus on the microbiology, medicine, and animal science communities (e.g., Bonilla-Aldana et al, 2020 ; Frutos et al, 2020 ). This contribution articulates a viewpoint from a perspective of human interactions with Earth systems, targeting an interdisciplinary community of human-environment scholars.…”

Section: Introductionmentioning

confidence: 99%

Pandemics and the future of human-landscape interactions

et al. 2020

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“…The world is now facing the rst corona viral pandemic. [1][2][3][4] Recently discovered SARS-CoV2 causes it.…”

Section: Introductionmentioning

confidence: 99%

Selocalcitol: Scope of inhalational formulation for prevention and cure of COVID-19 illness

Kaur

Yadav

Singh

et al. 2020

Preprint

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Vitamin D has generated interest in the context of COVID-19 pandemic. Some authorities believe that it is beneficial; others think that without proven deficiency it should not be administered. The results of clinical trial are still awaited. Therefore nothing regarding the matter is conclusively known. In this context we believe that selocalcitol, a Vitamin D analogue if administered via inhalational route, has the potential to prevent SARS-CoV2 infection. The basis of this idea is presented here.

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COVID-19: The Conjunction of Events Leading to the Coronavirus Pandemic and Lessons to Learn for Future Threats

Cited by 58 publications

References 28 publications

COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans

COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans

Pandemics and the future of human-landscape interactions

Selocalcitol: Scope of inhalational formulation for prevention and cure of COVID-19 illness

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