COVID‐19‐specific metabolic imprint yields insights into multiorgan system perturbations

Cornillet, Martin; Strunz, Benedikt; Rooyackers, Olav; Ponzetta, Andrea; Chen, Puran; Muvva, Jagadeeswara Rao; Akber, Mira; Buggert, Marcus; Chambers, Benedict J.; Dzidic, Majda; Filipovic, Iva; Gorin, Jean‐Baptiste; Gredmark‐Russ, Sara; Hertwig, Laura; Klingström, Jonas; Kokkinou, Efthymia; Kvedaraite, Egle; Lourda, Magda; Mjösberg, Jenny; Maucourant, Christopher; Norrby‐Teglund, Anna; Parrot, Tiphaine; Perez‐Potti, André; Rivera‐Ballesteros, Olga; Sandberg, Johan K.; Sandberg, J; Sekine, Takuya; Svensson, Mattias; Varnaitė, Renata; Eriksson, Lars; Aleman, Soo; Strålin, Kristoffer; Ljunggren, Hans‐Gustaf; Björkström, Niklas K.

doi:10.1002/eji.202149626

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…Cornillet et al [ 84 ] defined a “corrected” metabolome for hospitalized patients by excluding xenobiotics from the analysis of serum, which showed main alterations related to lipid species. Integration of the COVID-19 metabolome with proteomics and other clinical and immunological data highlighted multiple pathways for the immune activation, and organ injury, especially converging to neurological inflammation and tissue damage.…”

Section: Multiomics Studies Of Covid-19mentioning

confidence: 99%

COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19

Costanzo

Caterino

Fedele

et al. 2022

IJMS

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Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics techniques has been addressed to every level of application, from the detection of mutations, methods of diagnosis or monitoring, drug target discovery, and vaccine generation, to the basic definition of the pathophysiological processes and the biochemical mechanisms behind the infection and spread of SARS-CoV-2. Thus, the term COVIDomics wants to include those efforts provided by omics-scale investigations with application to the current COVID-19 research. This review summarizes the diverse pieces of knowledge acquired with the application of COVIDomics techniques, with the main focus on proteomics and metabolomics studies, in order to capture a common signature in terms of proteins, metabolites, and pathways dysregulated in COVID-19 disease. Exploring the multiomics perspective and the concurrent data integration may provide new suitable therapeutic solutions to combat the COVID-19 pandemic.

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Section: Multiomics Studies Of Covid-19mentioning

confidence: 99%

COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19

Costanzo

Caterino

Fedele

et al. 2022

IJMS

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“…Clinical samples were transported to the Center for Infectious Medicine, Karolinska Institutet, and directly processed for immediate immunological research. Results from the studies were rapidly put together and presented in a series of publications 2‐9 . In parallel with acceptance of published papers, curated data were assembled and presented in an aggregated form in the Immune Atlas database, rapidly made available as an open resource (Figure 1).…”

Section: Immune Atlas Overviewmentioning

confidence: 99%

“…an in‐depth assessment of >1000 unique metabolites. These results have been integrated with available proteomic and immunology data to capture multiorgan system perturbations 9 …”

Section: Immune Atlas Overviewmentioning

confidence: 99%

“…Results from the studies were rapidly put together and presented in a series of publications. 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 In parallel with acceptance of published papers, curated data were assembled and presented in an aggregated form in the Immune Atlas database, rapidly made available as an open resource (Figure 1 ).…”

Section: Immune Atlas Overviewmentioning

confidence: 99%

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The Karolinska KI/K COVID‐19 immune atlas: An open resource for immunological research and educational purposes

et al. 2022

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The Karolinska KI/K COVID‐19 Immune Atlas project was conceptualized in March 2020 as a part of the academic research response to the developing SARS‐CoV‐2 pandemic. The aim was to rapidly provide a curated dataset covering the acute immune response towards SARS‐CoV‐2 infection in humans, as it occurred during the first wave. The Immune Atlas was built as an open resource for broad research and educational purposes. It contains a presentation of the response evoked by different immune and inflammatory cells in defined naïve patient‐groups as they presented with moderate and severe COVID‐19 disease. The present Resource Article describes how the Karolinska KI/K COVID‐19 Immune Atlas allows scientists, students, and other interested parties to freely explore the nature of the immune response towards human SARS‐CoV‐2 infection in an online setting.

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“…On the other hand, it is well-known that the presence of comorbidities (e.g. metabolic syndrome, obesity, diabetes, and hypertension, among others) and age-related issues may hide important biochemical and metabolic characteristics derived from SARS-CoV-2 infection [19,20], as they may predispose to or are, per se, chronic inflammatory conditions that may alter the metabolic equilibrium as part of their pathophysiology and thereby significantly impact COVID-19 progression.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics analysis identifies glutamic acid and cystine imbalances in COVID-19 patients without comorbid conditions. Implications on redox homeostasis and COVID-19 pathophysiology

et al. 2022

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It is well known that the presence of comorbidities and age-related health issues may hide biochemical and metabolic features triggered by SARS-CoV-2 infection and other diseases associated to hypoxia, as they are by themselves chronic inflammatory conditions that may potentially disturb metabolic homeostasis and thereby negatively impact on COVID-19 progression. To unveil the metabolic abnormalities inherent to hypoxemia caused by COVID-19, we here applied gas chromatography coupled to mass spectrometry to analyze the main metabolic changes exhibited by a population of male patients less than 50 years of age with mild/moderate and severe COVID-19 without pre-existing comorbidities known to predispose to life-threatening complications from this infection. Several differences in serum levels of particular metabolites between normal controls and patients with COVID-19 as well as between mild/moderate and severe COVID-19 were identified. These included increased glutamic acid and reduced glutamine, cystine, threonic acid, and proline levels. In particular, using the entire metabolomic fingerprint obtained, we observed that glutamine/glutamate metabolism was associated with disease severity as patients in the severe COVID-19 group presented the lowest and higher serum levels of these amino acids, respectively. These data highlight the hypoxia-derived metabolic alterations provoked by SARS-CoV-2 infection in the absence of pre-existing co-morbidities as well as the value of amino acid metabolism in determining reactive oxygen species recycling pathways, which when impaired may lead to increased oxidation of proteins and cell damage. They also provide insights on new supportive therapies for COVID-19 and other disorders that involve altered redox homeostasis and lower oxygen levels that may lead to better outcomes of disease severity.

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COVID‐19‐specific metabolic imprint yields insights into multiorgan system perturbations

Cited by 7 publications

References 22 publications

COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19

COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19

The Karolinska KI/K COVID‐19 immune atlas: An open resource for immunological research and educational purposes

Metabolomics analysis identifies glutamic acid and cystine imbalances in COVID-19 patients without comorbid conditions. Implications on redox homeostasis and COVID-19 pathophysiology

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