COVID-19-related pericarditis with pericardial clotting as a hallmark: Two cases and a review

Parato, Vito Maurizio; Notaristefani, Camilla; D’Agostino, Simone; D’Emilio, Vittorio; Colella, Sara; Kadiyala, Madhavi; Pierantozzi, Silvia; Principi, Tiziana

doi:10.4103/jcecho.jcecho_124_20

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…With the spread of the pandemic COVID-19 and SARS-CoV-2 vaccines, cardiovascular involvement, even long-term, has been reported. [ 33 34 35 36 37 38 39 40 41 42 43 ] The pericardial disease primarily associated with these situations is known to be acute pericarditis. [ 44 45 ] However, we found >10 case reports of CP following the diagnosis of COVID-19 or the administration of mRNA-vaccine,[ 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 ] with a temporal relationship ranging from 4 days to 7 months, and without predilection for age groups.…”

Section: N Oninvasive D Iagnosis Of ...mentioning

confidence: 99%

Constrictive Pericarditis: An Update on Noninvasive Multimodal Diagnosis

Restelli,

Carerj,

Bella

et al. 2023

Journal of Cardiovascular Echography

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Constrictive pericarditis (CP) is a rare condition that can affect the pericardium after every pericardial disease process and has been described even after SARS-CoV-2 infection or vaccine. In CP, the affected pericardium, usually the inner layer, is noncompliant, constraining the heart to a fixed maximum volume and impairing the diastolic function. This leads to several clinical features, that, however, can be pleomorphic. In its difficult diagnostic workup, noninvasive multimodal imaging plays a central role, providing important morphological and functional data, like the enhanced ventricular interdependence and the dissociation between intrathoracic and intracardiac pressures. An early and proper diagnosis is crucial to set an appropriate therapy, changing the prognosis of patients affected by CP. In this review, we cover in detail the main elements of each imaging technique, after a reminder of pathophysiology useful for understanding the diagnostic findings.

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Section: N Oninvasive D Iagnosis Of ...mentioning

confidence: 99%

Constrictive Pericarditis: An Update on Noninvasive Multimodal Diagnosis

Restelli,

Carerj,

Bella

et al. 2023

Journal of Cardiovascular Echography

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“…In this sense, typical representatives are clotting components and elements of the complement cascade ( Pryzdial et al, 2022 ). Interestingly, the acceleration of the clotting process and clot formation in whole blood and platelet-poor plasma are physiological events that can be noted in the pathophysiology of COVID-19 ( Parato et al, 2021 ).…”

Section: Covid-19 Immune Function Diabetes and Obesitymentioning

confidence: 99%

Leukocyte metabolism in obese type 2 diabetic individuals associated with COVID-19 severity

et al. 2022

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Recent studies show that the metabolic characteristics of different leukocytes, such as, lymphocytes, neutrophils, and macrophages, undergo changes both in the face of infection with SARS-CoV-2 and in obesity and type 2 diabetes mellitus (DM2) condition. Thus, the objective of this review is to establish a correlation between the metabolic changes caused in leukocytes in DM2 and obesity that may favor a worse prognosis during SARS-Cov-2 infection. Chronic inflammation and hyperglycemia, specific and usual characteristics of obesity and DM2, contributes for the SARS-CoV-2 replication and metabolic disturbances in different leukocytes, favoring the proinflammatory response of these cells. Thus, obesity and DM2 are important risk factors for pro-inflammatory response and metabolic dysregulation that can favor the occurrence of the cytokine storm, implicated in the severity and high mortality risk of the COVID-19 in these patients.

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“…The impact of the global health crisis due to the virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)—the causative pathogen of the coronavirus disease 2019 (COVID-19)—has begun to alter with the timely development, approval and administration of vaccines [ 1 ]. Although SARS-CoV-2 infection primarily targets the respiratory system [ [2] , [3] , [4] , [5] , [6] ], it is now recognised that the infection and its clinical manifestations are systemic [ [7] , [8] , [9] , [10] , [11] , [12] ], and also affecting the cardiovascular system of adults and children [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ]. Cardiac complications of variable severity with acute and long-term sequelae are now known to include acute myocardial injury, arrhythmias, vasculitis and endothelial dysfunction, thrombosis, myocardial fibrosis, and myocarditis [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] ].…”

mentioning

confidence: 99%

“…Although SARS-CoV-2 infection primarily targets the respiratory system [ [2] , [3] , [4] , [5] , [6] ], it is now recognised that the infection and its clinical manifestations are systemic [ [7] , [8] , [9] , [10] , [11] , [12] ], and also affecting the cardiovascular system of adults and children [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ]. Cardiac complications of variable severity with acute and long-term sequelae are now known to include acute myocardial injury, arrhythmias, vasculitis and endothelial dysfunction, thrombosis, myocardial fibrosis, and myocarditis [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] ]. The cardiovascular and cellular pathophysiology of COVID-19, and the clinical management of previously healthy subjects and patients with existing cardiovascular or other disease conditions remain under intense investigation particularly as early in the pandemic, myocarditis was identified as a risk factor for increased mortality in COVID-19 patients [ [23] , [24] , [25] ].…”

mentioning

confidence: 99%