Myocarditis, Pericarditis and Cardiomyopathy After COVID-19 Vaccination

Pepe, Salvatore; Gregory, Ann; Denniss, A. Robert

doi:10.1016/j.hlc.2021.07.011

Cited by 48 publications

(51 citation statements)

References 27 publications

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“…Although the authors have limited this to the reactogenicity of the mRNA vaccines only, there is growing evidence suggesting possible links between myocarditis and vector-based vaccines (particularly the COVID-19 AstraZeneca (ChAdOx1 nCoV-19) vaccine). These are reports by the United Kingdom Medicines and Healthcare Products Regulatory Agency as part of the open “Yellow card” reporting system [ 16 , 17 ]. It remains unclear whether a similar mechanism exists for myocarditis related to vector-based vaccines.…”

Section: Discussionmentioning

confidence: 99%

From Muscles to Wires: Report of Two Cases and Literature Review on COVID-19 Vaccination and Cardiac Conduction Disturbance

Ahmad¹,

Mohamed²,

Saidahmed³

et al. 2021

Cureus

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Since the end of 2020, several vaccines have become available as part of the global efforts to contain the adverse health outcomes of the coronavirus disease 2019 (COVID-19) pandemic. Although research has confirmed their safety on large scales, several post-marketing reports have revealed some rare cardiovascular side effects. Towards the end of the first half of 2021, multiple reports indicate possible links between COVID-19 vaccines (both mRNA-based vaccine and vector-based vaccines) and myopericarditis. Nevertheless, cardiac conduction disease in this context has only rarely been reported.In this report, we present two cases of probable vaccination-induced cardiac conduction disturbances along with a thorough literature review. In addition, we discuss probable pathophysiological mechanisms and insights into the suggested areas for future research. To our knowledge, these are the first published cases to result in permanent pacemaker implantation.

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Section: Discussionmentioning

confidence: 99%

From Muscles to Wires: Report of Two Cases and Literature Review on COVID-19 Vaccination and Cardiac Conduction Disturbance

Ahmad¹,

Mohamed²,

Saidahmed³

et al. 2021

Cureus

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“…To the best of our knowledge, to the submission date, this is the first reported case of acute pericarditis likely related to COVID-19 vaccination in 54 year women. Rare case series of vaccine-related pericarditis have been reported when using mRNA vaccines against COVID-19, particularly in adolescents and young adults (<30 years) and mainly male; symptom onset is usually within 1 week following vaccination (13)(14)(15). Clinical course appears to be mild in most cases, these patients can usually return to their normal daily activities after their symptoms improve (13,14).…”

Section: Discussionmentioning

confidence: 99%

“…Rare case series of vaccine-related pericarditis have been reported when using mRNA vaccines against COVID-19, particularly in adolescents and young adults (<30 years) and mainly male; symptom onset is usually within 1 week following vaccination (13)(14)(15). Clinical course appears to be mild in most cases, these patients can usually return to their normal daily activities after their symptoms improve (13,14). A study in forty hospitals in Washington, Oregon, Montana, and Los Angeles County (individuals 2000287 least 1 COVID-19 vaccination) showed 37 vaccinated patients who subsequently had diagnoses of acute pericarditis, mostly were male (73%), and the median age was 59 years, 13 patients were admitted to the hospital, none to intensive care and none of them died (16).…”

Section: Discussionmentioning

confidence: 99%

A Case of Acute Pericarditis After COVID-19 Vaccination

et al. 2021

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A two-dose regimen of Pfizer–BioNTech COVID-19 vaccination confers 95% protection against COronaVIrus Disease 19 (COVID-19) and the safety profile is adequate. To the submission date, there were no reports in literature of acute pericarditis after BNT162b2 vaccination. However, pericarditis has been reported as a rare event associated with COVID-19 infection, which could be due to the pro-inflammatory effects of the spike protein. Recent evidence of post-vaccine myocarditis has been published. Herein we describe the case of a middle-aged healthy women who developed symptoms and signs of acute pericarditis 7–10 days after the second dose of Pfizer–BioNTech COVID-19 vaccination. Although a direct effect cannot be stated, it is important to report a potential adverse vaccine reaction effect that could be associated with the expression of SARS-CoV-2 spike protein induced from the mRNA of the vaccine.

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“…2021 has seen further articles about COVID-19 but rather than initial, well-considered pandemic guidance offered by experts and projections and predictions of likely effects to come, we are now seeing original contributions and commentary about the lived experience from the “fields of battle” in Australia and elsewhere in terms of: the acute disease, its manifestations and complications [ [33] , [34] , [35] , [36] , [37] , [38] ]; the adaptations to and opportunities in COVID-19 care [ 39 , 40 ] and in other care settings [ 41 ]; the effects of the COVID-19 pandemic on diagnostic cardiac procedural volumes [ 42 , 43 ] and cardiac surgery [ 44 , 45 ]; and, more recently, the reported side-effects of COVID-19 vaccination [ 46 , 47 ].…”

Section: : More About Covid-19mentioning

confidence: 99%

“…Reports of myocarditis after COVID-19 vaccination, especially mRNA vaccination, have come to notice—thankfully, it is found to be mostly mild, and to respond well to treatment, with relatively rapid symptom improvement [ 46 , 49 ]. Heart, Lung and Circulation has also published a novel case report from Swiss authors of Takotsubo cardiomyopathy after mRNA COVID-19 vaccination [ 47 ].…”

Section: : More About Covid-19mentioning

confidence: 99%