COVID-19-related myocarditis and cholinergic anti-inflammatory pathways

Liu, Weike; Liu, Zhendong; Li, Yuechun

doi:10.1016/j.hjc.2020.12.004

Cited by 12 publications

(12 citation statements)

References 84 publications

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“…Also, it was speculated that the spike protein effects on multiple autoantibody pathways which may be related to the cholinergic anti-inflammatory pathway. [10] On the other hand, a negative nucleocapsid antibody test result does not conclusively rule out the possibility of natural infection. [4,10]…”

Section: Discussionmentioning

confidence: 99%

Multisystem inflammatory syndrome in a male adolescent after his second Pfizer-BioNTech COVID-19 vaccine: a report from Turkey

Alp

Doğan

2022

Journal of Contemporary Medicine

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread rapidly through human populations, presenting across a continuum of severity from a symptomatic carriage to multi-organ failure and death. Multisystem inflammatory syndrome in children (MIS-C) is a new phenomenon reported worldwide with temporal association with SARS-CoV-2. Multisystem inflammatory syndrome in children is a complication of the SARS-CoV-2 infection, while myocarditis is a rare adverse effect to messenger ribonucleic acid (mRNA) SARS-CoV-2 vaccines, especially in males aged 12–17 years . On the other hand, postimmunization myocarditis is a known rare adverse event after other vaccinations, such as smallpox . Today, rare cases of MIS-C and myocarditis after mRNA SARS-CoV-2 vaccinations have been reported in children or adolescents . We present details on a 15-year-old previously healthy Turkish male adolescent who fulfilled the diagnostic criteria for MIS-C after the Pfizer-BioNTech vaccine.

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Section: Discussionmentioning

confidence: 99%

Multisystem inflammatory syndrome in a male adolescent after his second Pfizer-BioNTech COVID-19 vaccine: a report from Turkey

Alp

Doğan

2022

Journal of Contemporary Medicine

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“…Increased circulating clotting levels have been widely reported in COVID-19 patients undergoing dialysis. In addition, elevated myocardial damage, similar to myocardial infarction, is a possible outcome of myocardial tissue microangiopathy and myocarditis in patients with COVID-19 [76] . Therefore, hypercoagulation might spread acute tubular necrosis to cortical necrosis and thus, induce irreversible kidney damage in severe COVID-19 cases.…”

Section: Patients With Covid-19 and Secondary Nephropathymentioning

confidence: 99%

Highly pathogenic coronaviruses and the kidney

Wang¹,

Suo²,

Wang³

et al. 2022

Biomedicine & Pharmacotherapy

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“…The CAP may be more relevant in a SARS-2-CoV infection compared with other physiological mechanisms because further evidence indicates that the vagus nerve plays a relevant role in pulmonary inflammation (dos Santos et al, 2011 ). A detailed description of the neuroimmune mechanisms related to a possible CAP and its impairment in the case of this infection can be found elsewhere (Leitzke et al, 2020 ; Liu W. et al, 2020 ). In SARS-CoV-2 infections, young patients generally experience mild symptoms, while fatal interstitial pneumonia is more frequently reported in older patients.…”

Section: The Cap and Covid-19mentioning

confidence: 99%

A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway

et al. 2021

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The emergent Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) could produce a maternal immune activation (MIA) via the inflammatory response during gestation that may impair fetal neurodevelopment and lead to postnatal and adulthood mental illness and behavioral dysfunctions. However, so far, limited evidence exists regarding long-term physiological, immunological, and neurodevelopmental modifications produced by the SARS-CoV-2 in the human maternal-fetal binomial and, particularly, in the offspring. Relevant findings derived from epidemiological and preclinical models show that a MIA is indeed linked to an increased risk of neurodevelopmental disorders in the offspring. We hypothesize that a gestational infection triggered by SARS-CoV-2 increases the risks leading to neurodevelopmental disorders of the newborn, which can affect childhood and the long-term quality of life. In particular, disruption of either the maternal or the fetal cholinergic anti-inflammatory pathway (CAP) could cause or exacerbate the severity of COVID-19 in the maternal-fetal binomial. From a translational perspective, in this paper, we discuss the possible manifestation of a MIA by SARS-CoV-2 and the subsequent neurodevelopmental disorders considering the role of the fetal-maternal cytokine cross-talk and the CAP. Specifically, we highlight the urgent need of preclinical studies as well as multicenter and international databanks of maternal-fetal psychophysiological data obtained pre-, during, and post-infection by SARS-CoV-2 from pregnant women and their offspring.

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COVID-19-related myocarditis and cholinergic anti-inflammatory pathways

Cited by 12 publications

References 84 publications

Multisystem inflammatory syndrome in a male adolescent after his second Pfizer-BioNTech COVID-19 vaccine: a report from Turkey

Multisystem inflammatory syndrome in a male adolescent after his second Pfizer-BioNTech COVID-19 vaccine: a report from Turkey

Highly pathogenic coronaviruses and the kidney

A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway

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