COVID‐19 patients with documented alcohol use disorder or alcohol‐related complications are more likely to be hospitalized and have higher all‐cause mortality

Bailey, Kristina L.; Sayles, Harlan; Campbell, James; Khalid, Neha; Anglim, Madyson; Ponce, Jana; Wyatt, Todd A.; McClay, James C.; Burnham, Ellen L.; Anzalone, Alfred J.; Hanson, Corrine

doi:10.1111/acer.14838

Cited by 28 publications

(30 citation statements)

References 81 publications

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“…To our knowledge, this is the first cross-sectional study to support AUD association with severity of COVID-19. A more recent cross-sectional study also supports this study and was much more comprehensive involving 44 Medical Centers and used healthy patients vs. those with documented AUD (Bailey et al, 2022). This study also found that after adjustment for age, sex, BMI, and other comorbidities AUD still resulted in higher odds of all-cause mortality (aOR 1.55, CI 1.46 to 1.65, p < 0.001) in COVID-19 patients (Bailey et al, 2022).…”

Section: Alcohol Abus E a S A Ris K Fac Tor For Covid -19 S E Verit Ysupporting

confidence: 74%

“…A more recent cross-sectional study also supports this study and was much more comprehensive involving 44 Medical Centers and used healthy patients vs. those with documented AUD (Bailey et al, 2022). This study also found that after adjustment for age, sex, BMI, and other comorbidities AUD still resulted in higher odds of all-cause mortality (aOR 1.55, CI 1.46 to 1.65, p < 0.001) in COVID-19 patients (Bailey et al, 2022). A third recent study was conducted in mice using the NIAAA chronic alcohol feeding model and the spike S1 protein of the SARS-CoV-2 virus.…”

Section: Alcohol Abus E a S A Ris K Fac Tor For Covid -19 S E Verit Ysupporting

confidence: 64%

“…Although the direct human evidence for COVID-19 is limited to the recent studies cited above (Bailey et al, 2022;Bhalla et al, 2021), these data are supported by a large body of previous data for alcohol misuse effects in SARS and death and even risk of SARS-CoV-2 infection similar to alcohol use effects on SARS severity and ARDS as we discuss below (Bailey et al, 2021;Testino, 2020). There are no clear data yet on effects of alcohol consumption specifically on COVID-19 vaccine effectiveness or side effects (Bailey et al, 2021).…”

Section: Alcohol Abus E a S A Ris K Fac Tor For Covid -19 S E Verit Ymentioning

confidence: 88%

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Alcohol use disorder as a potential risk factor forCOVID‐19 severity: A narrative review

Forsyth

Voigt

Swanson

et al. 2022

Alcoholism Clin & Exp Res

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In Dec. 2019‐January 2020, a pneumonia illness originating in Wuhan, China, designated as coronavirus disease 2019 (COVID‐19) was shown to be caused by a novel RNA coronavirus designated as severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). People with advanced age, male sex, and/or underlying health conditions (obesity, type 2 diabetes, cardiovascular disease, hypertension, chronic kidney disease, and chronic lung disease) are especially vulnerable to severe COVID‐19 symptoms and death. These risk factors impact the immune system and are also associated with poor health, chronic illness, and shortened longevity. However, a large percent of patients without these known risk factors also develops severe COVID‐19 disease that can result in death. Thus, there must exist risk factors that promote exaggerated inflammatory and immune response to the SARS‐CoV‐2 virus leading to death. One such risk factor may be alcohol misuse and alcohol use disorder because these can exacerbate viral lung infections like SARS, influenza, and pneumonia. Thus, it is highly plausible that alcohol misuse is a risk factor for either increased infection rate when individuals are exposed to SARS‐CoV‐2 virus and/or more severe COVID‐19 in infected patients. Alcohol use is a well‐known risk factor for lung diseases and ARDS in SARS patients. We propose that alcohol has three key pathogenic elements in common with other COVID‐19 severity risk factors: namely, inflammatory microbiota dysbiosis, leaky gut, and systemic activation of the NLRP3 inflammasome. We also propose that these three elements represent targets for therapy for severe COVID‐19.

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Section: Alcohol Abus E a S A Ris K Fac Tor For Covid -19 S E Verit Ysupporting

confidence: 74%

Section: Alcohol Abus E a S A Ris K Fac Tor For Covid -19 S E Verit Ysupporting

confidence: 64%

Section: Alcohol Abus E a S A Ris K Fac Tor For Covid -19 S E Verit Ymentioning

confidence: 88%

See 1 more Smart Citation

Alcohol use disorder as a potential risk factor forCOVID‐19 severity: A narrative review

Forsyth

Voigt

Swanson

et al. 2022

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

“…Those lifestyles had been recognized as risk factors for developing comorbid that could worsen the outcome of COVID-19. 25,26 As found in the older age group, circulating ACE2 levels were also higher in male compared to female. 6 It makes males have a higher vulnerability to getting severity or even death.…”

Section: Discussionmentioning

confidence: 65%

Sex and age differences in the COVID-19 mortality in East Jakarta, Indonesia: Analysis of COVID-19 surveillance system

Sumiati¹,

Aini

Tama

2022

J Public Health Afr

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Demographic factors have been reported to worsen COVID-19 outcomes. However, there is limited evidence about the different effects of sex and age on COVID-19 death in East Jakarta, Indonesia. This study examined the association between sex and age with COVID-19 mortality. Using COVID- 19 surveillance data of East Jakarta from March 2020 to December 2021, we calculated COVID-19 mortality and examined the risk of COVID-19 death by sex and age. The risk of COVID-19 death associated with sex and age was examined by using Multiple Logistic Regression. A total of 202.412 cases were analyzed and 1.9% of them died. The elderly had a 41.88-folds increased risk of COVID-19 mortality than younger patients (<45 years) (aOR 41.88; 95% CI 37.49-46.77; p-value <0.0001). Male had a higher risk of COVID-19 death compared to female (aOR 1.27; 95% CI 1.19-1.35; pvalue <0.0001). Age and sex had a significant association with COVID-19 mortality. Adequate management of COVID-19 cases, particularly in the elderly and male patients, may reduce the severity of COVID-19 or even mortality.

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“…Prior investigations have demonstrated dose-dependent associations between alcohol misuse and poorer outcomes in patients hospitalized with pneumonia including increased risk for prolonged hospital and ICU lengths of stay and development of the acute respiratory distress syndrome (ARDS) (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). While changes in alcohol consumption have been consistently observed during the COVID-19 pandemic, the impact of alcohol misuse on healthcare outcomes related to COVID-19 are conflicted.…”

mentioning

confidence: 99%

Impact of Alcohol Misuse on Requirements for Critical Care Services and Development of Hospital Delirium in Patients With COVID-19 pneumonia

Jolley

Mowry

Erlandson

et al. 2023

Critical Care Explorations

Self Cite

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OBJECTIVES: Alcohol misuse has been associated with increased morbidity in the setting of pulmonary infections, including the need for critical care resource utilization and development of delirium. How alcohol misuse impacts morbidity and outcomes among patients admitted with COVID-19 pneumonia is not well described. We sought to determine if alcohol misuse was associated with an increased need for critical care resources and development of delirium among patients hospitalized with COVID-19 pneumonia. DESIGN: Retrospective cohort study. SETTING: Twelve University of Colorado hospitals between March 2020 and April 2021. PATIENTS: Adults with a COVID-19 diagnosis. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was admission to the ICU. Secondary outcomes included need for mechanical ventilation, development of delirium, and in-hospital mortality. Alcohol misuse was defined by International Classification of Diseases , 10th Revision codes. Of 5,979 patients hospitalized with COVID-19, 26% required ICU admission and 15.4% required mechanical ventilation. Delirium developed in 4.5% and 10.5% died during hospitalization. Alcohol misuse was identified in 4%. In analyses adjusted for age, sex, body mass index, diabetes, and liver disease, alcohol misuse was associated with increased odds of ICU admission (adjusted odds ratio [aOR], 1.46; p < 0.01), mechanical ventilation (aOR, 1.43; p = 0.03), and delirium (aOR, 5.55; p < 0.01) compared with patients without misuse. Mortality rates were not associated with alcohol misuse alone, although the presence of both alcohol misuse and in-hospital delirium significantly increased odds of in-hospital death (aOR, 2.60; p = 0.04). CONCLUSIONS: Among patients hospitalized with COVID-19, alcohol misuse was associated with increased utilization of critical care resources including ICU admission and mechanical ventilation. Delirium was an important modifiable risk factor associated with worse outcomes in hospitalized patients with alcohol misuse, including increased odds of death.

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COVID‐19 patients with documented alcohol use disorder or alcohol‐related complications are more likely to be hospitalized and have higher all‐cause mortality

Cited by 28 publications

References 81 publications

Alcohol use disorder as a potential risk factor forCOVID‐19 severity: A narrative review

Alcohol use disorder as a potential risk factor forCOVID‐19 severity: A narrative review

Sex and age differences in the COVID-19 mortality in East Jakarta, Indonesia: Analysis of COVID-19 surveillance system

Impact of Alcohol Misuse on Requirements for Critical Care Services and Development of Hospital Delirium in Patients With COVID-19 pneumonia

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