COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India

Patel, Atul; Patel, Dhruv; Shevkani, Manoj; Shah, Aniket; Madan, Surabhi; Gohel, Swati; Chhatwani, Chirag; Doshi, Aakash; Patel, Vipul; Sukhwani, Kalpesh; Kareliya, Hiten; Shah, Viral B.; Savaj, Pratik; Rana, Manish; Patel, Ketan; Bakshi, Harsh

doi:10.1016/j.ijmmb.2022.12.004

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…The results of Atul K et al’s cohort study during the third wave in Western India also showed an increase in mortality in patients with low Ct values through univariate analysis and adjusted logistic regression, supporting the idea that the vaccination protects against severe illness, hospitalization, and death caused by COVID-19 [ 15 ]. Furthermore, the Ct values of vaccinated individuals tend to be higher than those of unvaccinated individuals [ 16 , 17 ] and increase more rapidly after symptom onset, which supports the notion that viral load decreases more rapidly in vaccinated patients [ 18 ].…”

Section: Discussionmentioning

confidence: 82%

Comparative Study on Two COVID-19 Outbreaks at a Long-Term Mental Health Facility in Korea in 2020 and 2022

Kim

Choi

et al. 2023

Medicina

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(1) Background and Objectives: There were two distinct coronavirus disease 2019 (COVID-19) outbreaks in 2020 and 2022 at a long-term mental health facility (LTMHF) in Gyeonggi Province, Korea. We aimed to compare the two outbreaks and identify differences in epidemiological and clinical outcomes due to changes in epidemic timing and management methods. (2) Materials and Methods: The structural, operational, and case-specific LTMHF data of COVID-19-confirmed patients during these outbreaks in 2020 and 2022 were retrospectively analyzed. (3) Results: Forty individuals (37 residents) in 2020 and thirty-nine (32 residents) in 2022 were confirmed to have COVID-19, and ten were infected twice. Facility isolation was implemented as an infection control measure, and one COVID-19-related death occurred in 2020. All residents and staff were vaccinated at least twice in 2022; moreover, in 2022, 38 patients (97.4%) received a third vaccination less than months before infection. The average Ct value of the cases in 2022 was significantly higher than that in 2020; however, vaccine-breakthrough (V-BT) and reinfection after vaccination rates were similar. (4) Conclusions: COVID-19 vaccination could help lower the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was inversely correlated with Ct values, and ventilation system improvements in health facilities might reduce transmissibility.

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Section: Discussionmentioning

confidence: 82%

Comparative Study on Two COVID-19 Outbreaks at a Long-Term Mental Health Facility in Korea in 2020 and 2022

Kim

Choi

et al. 2023

Medicina

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The effect of vaccination against the COVID-19 on the course and outcomes of a new coronavirus infection: a retrospective analysis of laboratory and clinical indicators of hospitalized patients

Fomicheva,

Pimenov,

Tsygankova

et al. 2024

Epidemiology and Infectious Diseases

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Aims: to assess the effect of vaccination against the COVID-19 on the severity of the current and the outcome of a new coronavirus infection in hospitalized patients during the dominance of the SARS-CoV-2 Omicron. Materials and methods: study of the type of case-control included adult patients hospitalized in the infectious hospital of Moscow from February 1, 2022 to July 31, 2022 with a diagnosis of COVID-19 (U07.1) (N = 119). The main group included persons vaccinated with 2 doses of the Sputnik V vaccine (n = 59). Unvaccinated patients were included in the control group (n = 60). The median age of patients amounted to 66 years [IQR: 41-66], 58.8% were female. Chi square test for categorical and Mann Whitney test for continuous variables were applied for the analysis. P values 0,05 were considered statistically significant. Results: viral pneumonia was less likely to develop in vaccinated persons compared to unvaccinated persons (46.7% and 18.6%, respectively, p=0.007). The share of patients without lung damage (KT-0) among vaccinated (72.0%) was significantly higher than that of unvaccinated patients (42.9%) (p=0.003). In the group of vaccinated the levels of C-reactive protein, when entering the hospital was lower (29.1 [7.4-68, 6] mg/L and 75.1 [32.4-104.0] mg/L, p0.001), as the highest level of C-reactive protein during hospitalization (38.2 [12.0-84.0] mg/L and 92.2 [45.3-137.4] mg/L, p0.001). The level of D-dimer before discharge was lower in group of patients vaccinated ≤6 months ago compared with unvaccinated (157.0 [107.0-297.0] ng/ml and 316.0 [125.0-556.0] ng/ml, p=0.014). The frequency of deaths in the control group (11.7%) was 6.9 times higher compared to the main group (1.7%) (p=0.030). Conclusions: the completed primary vaccination course of the Sputnik V vaccine provided lower levels of prognostic markers of the adverse course of COVID-19 (C-reactive protein, D-dimer), as well as a decrease in the frequency of pulmonary and fatal outcome compared to unvaccinated patients during the dominance of the Omicron SARS-CoV-2.

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Diagnostic Agreement of SARS-CoV-2 Lateral Flow Antigen Assay with the Cycle Threshold Values of RT-PCR

Murthy¹,

Sumana²,

Tejashree³

et al. 2023

J. Pure Appl. Microbiol.

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COVID-19 detection via lateral flow antigen assays (LFA) are rapid and economically acquiescent to infrastructure facile healthcare settings. Early, prompt identification of cases to facilitate patient isolation and supportive management is the essence of rapid diagnostic tests. Given the backdrop of post COVID-19 pandemic-molecular testing still remains a costly affair. Additionally, molecular assays are incapable of distinguishing remnant RNA from replication competent viruses. In this scenario, we explore the diagnostic consonance of SARS-CoV-2 LFAs with RT-PCR cycle threshold, in a likelihood that it could be used as a surrogate marker for infection transmissibility. Rapid COVID-19 LFA results were compared with Real-time PCR for detection of SARS-CoV-2 in nasopharyngeal swabs. Two hundred rapid antigen positive nasopharyngeal swabs obtained from COVID-19 suspects/contacts/preoperative/screening patients were subjected to RT-PCR to study the correlation with cycle threshold (CT) values obtained for all the antigen positive cases. 200 Rapid COVID-19 LFA positive samples were analyzed in the present study. Amidst the LFA positive samples included in the study 187 (93.5%) were found to have concordant results when subjected to the gold standard Real-time PCR. Discordant results were documented in 13 (6.5%) COVID-19 LFA positive samples which were found to be negative by RT-PCR. The average Cycle threshold values were found to be 23.75 for E gene, 25.36 for N gene and 24.07 for RdRp gene. The average PCR Cycle threshold of LFA positive cases remained significantly undeterred (p<0.5) throughout the time period of the study stipulating the undaunted viral load across the different waves of the pandemic. Maximum association of LFA positivity with symptom-manifestation was seen during the 1st wave of COVID-19 (September-December 2020 in India). The association of symptoms with LFA test positivity reduced to a significant extent during the 3rd wave of the pandemic in January 2022 (p<0.5) indicating the reduced clinical severity but not infectivity of the SARS-CoV-2 infection during the 3rd wave of the pandemic. Lateral flow assay based diagnostic tests are technically & economically convenient modalities with significant interest concordance in comparison with RT-PCR. Definitive advantage in terms of achieving quick patient triage and thereby patient management can be achieved with the use of these tests.

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COVID-19 patients’ clinical profile and outcome with respect to their vaccination status: A prospective observational multicentre cohort study during third wave in Western India

Cited by 3 publications

References 29 publications

Comparative Study on Two COVID-19 Outbreaks at a Long-Term Mental Health Facility in Korea in 2020 and 2022

Comparative Study on Two COVID-19 Outbreaks at a Long-Term Mental Health Facility in Korea in 2020 and 2022

The effect of vaccination against the COVID-19 on the course and outcomes of a new coronavirus infection: a retrospective analysis of laboratory and clinical indicators of hospitalized patients

Diagnostic Agreement of SARS-CoV-2 Lateral Flow Antigen Assay with the Cycle Threshold Values of RT-PCR

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