COVID-19 pandemic: Its impact on liver disease and liver transplantation

Sahin, Tevfik Tolga; Akbulut, Sami; Yilmaz, Sezai

doi:10.3748/wjg.v26.i22.2987

Cited by 58 publications

(58 citation statements)

References 72 publications

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“…There is no definitive treatment or post-exposure prophylaxis for COVID-19 infection. Recently, hydroxychloroquine, lopinavir, ritonavir, and remdesivir therapy have been suggested as potential treatment options [ 13 ]. However, the effectiveness of all these treatments is not fully known.…”

Section: Discussionmentioning

confidence: 99%

A Recipient and Donor Both Have COVID-19 Disease. Should We Perform a Liver Transplant?

Tunçer

Akbulut

Başkıran

et al. 2021

J Gastrointest Canc

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Coronavirus 2019 (COVID-19) is a new infectious disease that continues to spread globally. There is growing concern about donor-induced transmission of Coronavirus 2 (SARS ‐CoV‐2). For liver transplantation, the COVID-19 PCR test is routine, in addition to epidemiological history and clinical and radiological examination 24–48 h before surgery. One of the liver transplant candidates was found to be infected with COVID-19, as well as the planned donor candidate. Since COVID-19 will be a high-risk operation for both the recipient and the donor, the operation was postponed by giving medical treatment. After the treatment and quarantine process was over, the patient and the donor then had a negative COVID-19 PCR test and the patient received a living donor liver transplant. We present a case of donor and recipient who initially both tested positive for COVID-19. This liver transplantation scenario has not previously been reported in the literature.

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Section: Discussionmentioning

confidence: 99%

A Recipient and Donor Both Have COVID-19 Disease. Should We Perform a Liver Transplant?

Tunçer

Akbulut

Başkıran

et al. 2021

J Gastrointest Canc

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“…Hepatologists and transplant surgeons are still evaluating the implications of this disease. 140 Based on previous findings, tissue engineering can once again provide a great opportunity to induce liver tissue repair in subjects suffering from chronic liver damage as a consequence of SARS-CoV-2 infection. In one such aspect, biomaterials which previously showed successful results in liver tissue regeneration can be used.…”

Section: Biomaterials Science Accepted Manuscriptmentioning

confidence: 97%

SARS-CoV-2 and tissue damage: current insights and biomaterial-based therapeutic strategies

2021

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“…The normal antigen-presenting cells are dendritic cells, macrophage cells, monocytes, plasma cells, etc. , introduced to viral particles CD8+ cytotoxic and CD4+ regulatory T lymphocytes, the major histocompatibility complexes[ 85 ].…”

Section: Sars-cov-2 and Angiotensin-converting Enzymementioning

confidence: 99%

“…The membrane-bound toll-like receptor (TLR) family among PRRs, predominantly recognizes PAMPs in the extracellular system and to a lesser degree in the intracellular milieu[ 87 ]. Activation of this signal contributes to increasing the expression of transcription factors that induce pro-inflammatory cytokine production, such as NF-κB, and activate immune defense against viral infection via the IFN type I pathway[ 85 , 88 ].…”

Section: Sars-cov-2 and Angiotensin-converting Enzymementioning

confidence: 99%

Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges

Ali¹,

Mohammedsaleh²,

Ali³

et al. 2021

WJG

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Coronavirus disease 2019 (COVID-19) is a devastating worldwide pandemic infection caused by a severe acute respiratory syndrome namely coronavirus 2 (SARS-CoV-2) that is associated with a high spreading and mortality rate. On the date this review was written, SARS-CoV-2 infected about 96 million people and killed about 2 million people. Several arguments disclosed the high mortality of COVID-19 due to acute respiratory distress syndrome or change in the amount of angiotensin-converting enzyme 2 (ACE2) receptor expression or cytokine storm strength production. In a similar pattern, hepatic impairment patients co-infected with SARS-CoV-2 exhibited overexpression of ACE2 receptors and cytokine storm overwhelming, which worsens the hepatic impairment and increases the mortality rate. In this review, the impact of SARS-CoV-2 on hepatic impairment conditions we overviewed. Besides, we focused on the recent studies that indicated cytokine storm as well as ACE2 as the main factors for high COVID-19 spreading and mortality while hinting at the potential therapeutic strategies.

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COVID-19 pandemic: Its impact on liver disease and liver transplantation

Cited by 58 publications

References 72 publications

A Recipient and Donor Both Have COVID-19 Disease. Should We Perform a Liver Transplant?

A Recipient and Donor Both Have COVID-19 Disease. Should We Perform a Liver Transplant?

SARS-CoV-2 and tissue damage: current insights and biomaterial-based therapeutic strategies

Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges

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