COVID-19 pandemic affects the ability of negative D-dimer to identify venous thromboembolism patients at low risk of recurrence: insights from the Apidulcis study

Palareti, Gualtiero; Legnani, Cristina; Poli, Daniela; Ageno, Walter; Pengo, Vittorio; Testa, Sophie; Tosetto, Alberto; Prandoni, Paolo

doi:10.3324/haematol.2022.282130

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…It is well established that the COVID -19 pandemic is associated with an increased rate of VTE events, which is not limited to the seriously affected patients. 57 Prediction models for the risk of venous thromboembolism recurrence Prediction models have been proposed to establish the recurrence risk of idiopathic or unprovoked VTE in the patients who have completed 3 to 6 months of anticoagulant therapy, and to assess whether such a risk is low enough to stop the therapy. There are as many as 17 models for VTE recurrence available.…”

Section: -Dimer Adjusted To Covid -19mentioning

confidence: 99%

D-dimer in diagnosis and prevention of venous thrombosis: recent advances and their practical implications

Cosmi,

Legnani,

Libra

et al. 2023

Polish Archives of Internal Medicine

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D -Dimers and venous thromboembolism 1 extent of fibrinolysis, and clearance of fibrin degradation products.D -Dimer level increases physiologically with age and during pregnancy and puerperium; it may be higher in African -Americans and in smokers. Increased D -dimer level is also observed in several pathologic conditions, in which stabilized fibrin is formed and subsequently degraded, such as in venous and arterial thrombosis, infectious diseases, neoplasms, trauma, surgery, liver disease, renal insufficiency, fibrinolytic therapy, disseminated intravascular coagulation (DIC), acute coronary syndromes, acute cerebrovascular events, subarachnoid hemorrhage, obstetric complications, or autoimmune disorders. 3 D -Dimer measurement D -Dimer level measurement was proposed as a laboratory test for the diagnosis of DIC in the 1970s; since then considerable advances have been made regarding its measurement, and its main clinical role is that in venous thromboembolism (VTE) diagnosis. 2 Introduction During hemostasis, activation of coagulation leads to the production of thrombin, which cleaves fibrinogen into fibrin monomers that finally form fibrin polymer. Thrombin also activates factor XIII, which stabilizes fibrin polymers with cross -linked covalent bonds. Activation of fibrinolysis leads to the production of plasmin, which cleaves cross -linked fibrin into various fragments, including D -dimers 1 (FIguRE 1). Plasmin produces several different degradation products with molecular weight (MW) ranging from 190 to over 10 000 kDa, and MW of D -dimers is about 180 kDa. 1 D -Dimers are mainly cleared by the kidney and reticulo -endothelial system, with a plasma half -life of 6 to 8 hours. 1,2 In physiological conditions, approximately 2%-3% of fibrinogen is converted into fibrin, which is then degraded by the fibrinolytic system. 1,2 As a result, D -dimers can be detected in low amounts in healthy individuals under physiological conditions. Plasma D -dimer concentration depends on the extent of factor XIIIa -stabilized fibrin formation,

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Section: -Dimer Adjusted To Covid -19mentioning

confidence: 99%