D-dimer and risk of venous thromboembolism recurrence: Comparison of two studies with similar designs but different laboratory and clinical results

Palareti, Gualtiero; Legnani, Cristina; Tosetto, Alberto; Poli, Daniela; Testa, Sophie; Ageno, Walter; Pengo, Vittorio; Cosmi, Benilde; Prandoni, Paolo

doi:10.1016/j.thromres.2024.04.018

Thrombosis Research

2024

DOI: 10.1016/j.thromres.2024.04.018

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D-dimer and risk of venous thromboembolism recurrence: Comparison of two studies with similar designs but different laboratory and clinical results

Gualtiero Palareti,

Cristina Legnani,

Alberto Tosetto

et al.

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An Electrochemical Biosensor for the Detection of Pulmonary Embolism and Myocardial Infarction

Chang,

Siao,

Lin

2024

Biosensors

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Due to the clinical similarities between pulmonary embolism (PE) and myocardial infarction (MI), physicians often encounter challenges in promptly distinguishing between them, potentially missing the critical window for the correct emergency response. This paper presents a biosensor, termed the PEMI biosensor, which is designed for the identification and quantitative detection of pulmonary embolism or myocardial infarction. The surface of the working electrode of the PEMI biosensor was modified with graphene oxide and silk fibroin to immobilize the mixture of antibodies. Linear sweep voltammetry was employed to measure the current-to-potential mapping of analytes, with the calculated curvature serving as a judgment index. Experimental results showed that the curvature exhibited a linear correlation with the concentration of antigen FVIII, and a linear inverse correlation with the concentration of antigen cTnI. Given that FVIII and cTnI coexist in humans, the upper and lower limits were determined from the curvatures of a set of normal concentrations of FVIII and cTnI. An analyte with a curvature exceeding the upper limit can be identified as pulmonary embolism, while a curvature falling below the lower limit indicates myocardial infarction. Additionally, the further the curvature deviates from the upper or lower limits, the more severe the condition. The PEMI biosensor can serve as an effective detection platform for physicians.

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An Electrochemical Biosensor for the Detection of Pulmonary Embolism and Myocardial Infarction

Chang,

Siao,

Lin

2024

Biosensors

View full text Add to dashboard Cite

show abstract

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D-dimer and risk of venous thromboembolism recurrence: Comparison of two studies with similar designs but different laboratory and clinical results

Cited by 1 publication

References 29 publications

An Electrochemical Biosensor for the Detection of Pulmonary Embolism and Myocardial Infarction

An Electrochemical Biosensor for the Detection of Pulmonary Embolism and Myocardial Infarction

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