Covid-19 intensive care admissions and mortality among swedish patients with cancer

Larfors, Gunnar; Pahnke, Simon; State, Maria; Fredriksson, Katarina; Pettersson, David

doi:10.1080/0284186x.2020.1854481

Cited by 14 publications

(29 citation statements)

References 15 publications

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“…An analysis from Sweden of COVID-19 positive patients showed that cancer patients who had undergone chemotherapy the past 90 days had a threefold increased risk of death from COVID-19. Further, patients diagnosed with cancer in 2019 or 2020 were at increased risk of death, especially patients with lung and hematological cancers (17).…”

Section: Introductionmentioning

confidence: 99%

COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway

et al. 2021

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BackgroundCancer has been suggested as a risk factor for severe outcome of SARS-CoV-2 infection. In this population-based study we aimed to identify factors associated with higher risk of COVID-19 and adverse outcome.MethodsData on all confirmed SARS-CoV-2 positive patients in the period January 1 to May 31, 2020 were extracted from the Norwegian Surveillance System for Communicable Diseases. Data on cancer and treatment was available from the Cancer Registry of Norway, the Norwegian Patient Registry and the Norwegian Prescription Database. Deaths due to COVID-19 were extracted from the Cause of Death Registry. From the Norwegian Intensive Care and Pandemic Registry we retrieved data on admittance to hospital and intensive care. We determined rates of COVID-19 disease in cancer patients and the rest of the population. We also ran multivariate analyses adjusting for age and gender.ResultsA total of 8 410 patients were diagnosed with SARS-CoV-2 infection in Norway during the study period, of which 547 (6.5%) were cancer patients. Overall, we found similar age adjusted rates of COVID-19 in the population with cancer as in the population without cancer. Unadjusted analysis showed that patients having undergone major surgery within the past 3 months had an increased risk of COVID-19 while we did not find increased Odds Ratio (OR) related to other oncological treatment modalities. No patients treated with stem cell or bone marrow transplant were diagnosed with COVID-19. The fatality rate of COVID-19 among cancer patients was 0.10. This was similar to non-cancer patients, when adjusting for age and sex with OR (95% CI) for death= 0.99 (0.68–1.42). Patients with distant metastases had significantly increased OR of death due to COVID-19 disease of 9.31 (95% CI 2.60–33.34). For the combined outcome death and/or admittance to hospital due to COVID-19, we found significant two-fold increased risk estimates for patients diagnosed with cancer less than one 1 year ago (OR 2.08, 95% CI 1.14–3.80), for those treated with anti-cancer drugs during the past 3 months (OR 1.80, 95% CI 1.07–3.01) and for patients undergoing major surgery during the past 3 months (OR 2.19, 95% CI 1.40–3.44).

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Section: Introductionmentioning

confidence: 99%

COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway

et al. 2021

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“…Since infection control strategies have been different in Sweden compared to other countries, the impact on cancer patients in this setting is particularly interesting and indicates that the Swedish COVID-19 strategy has not had a major impact on CFR in cancer patients. It was recently reported that patients with cancer had a higher incidence of positive SARS-CoV-2 tests in Sweden during the first three months of the pandemic [33]. The same study also reported that patients with cancer had significantly higher odds of COVID-19-related death and patients who received chemotherapy had a greater odds of ICU admission.…”

Section: Discussionmentioning

confidence: 82%

“…The same study also reported that patients with cancer had significantly higher odds of COVID-19-related death and patients who received chemotherapy had a greater odds of ICU admission. These conflicting findings might be because cancer patients were compared to the general population in Larfors et al [33] rather than different subgroups of cancer patients. Patients with cancer tend to have a more limited life expectancy and a higher median age than the general population.…”

Section: Discussionmentioning

confidence: 99%

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Clinical outcomes in cancer patients with COVID-19 in Sweden

Bondeson

Thulin

et al. 2021

Acta Oncologica

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Background:The results of studies on the relationship between cancer and COVID-19 have been conflicting and therefore further studies are needed. We aimed to examine the incidence of COVID-19 among patients at one of the largest oncology departments in Sweden, and to evaluate and identify risk factors for poor outcomes, hospital care and death, associated with COVID-19 among cancer patients. Material and methods: This retrospective study included cancer patients at a single center who tested positive for SARS-CoV-2 by PCR either in hospital, primary health care center or commercial laboratory between 1 March and 14 August 2020. Clinical and demographic data were collected from the medical records. Logistic regression analysis was used to identify variables that associated the primary outcomes of need for hospital care and death within 30 days of positive test.

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“…Although it has been asserted that cancer is associated with mortality and morbidity of COVID-19, findings have been contradictory regarding cancer directed treatments and outcomes of COVID-19. Some studies have suggested recent chemotherapy [11][12][13], surgery [11,14] and immune checkpoint inhibitors [14,15] to be associated with a greater risk of mortality in SARS-CoV-2 infected cancer patients, while other studies were unable to draw the same conclusions [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer: a Swedish cohort study

et al. 2021

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Introduction: Cancer patients are considered to have a higher risk of dying and developing severe Coronavirus Disease 2019 (COVID-19). To date, there are few studies including co-morbidities and sociodemographic factors when investigating the outcome of COVID-19 in a cohort of cancer patients. In this study, we analyzed cancer patients that have been hospitalized due to COVID-19 during the first wave of the pandemic in Sweden to investigate the impact of COVID-19 on mortality and morbidity. Patients and methods: We retrospectively collected data on all patients with cancer that were hospitalized due to COVID-19-related symptoms at

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Covid-19 intensive care admissions and mortality among swedish patients with cancer

Cited by 14 publications

References 15 publications

COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway

COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway

Clinical outcomes in cancer patients with COVID-19 in Sweden

Clinical characteristics and factors associated with COVID-19-related death and morbidity among hospitalized patients with cancer: a Swedish cohort study

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