COVID-19 Infection in First Trimester of Pregnancy Marked by a Liver Cytolysis: A Case Report.

Lamazou, F.; Guérin, Annie; Letouzey, V.; Octernaud, S; Place, Virgil A.; Descamps, Philippe; Delaroche, Lucie

doi:10.2139/ssrn.3597355

Cited by 2 publications

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“…Only a portion of the studies (9) reported some sort of complication during the span of pregnancy which pertained to 15 patients [22][23][24][25][26][27]37,39,40]. DIC 20% (3/15), preeclampsia 13% (2/15), as well as liver cytolysis, chorioamnionitis, ARDS, hyperemesis gravidarum, pneumothorax and gestational diabetes (each observed in 1/15 of the reported patients) were the most commonly observed complications.…”

Section: Pregnancy Related Complicationsmentioning

confidence: 99%

“…Out of 223 neonates, the outcomes of 60 infants (31/60: maternal infection during 1st trimester and 29/60: 2nd trimester infections) from 20 studies were specified as either deceased/terminated, misscariage, alive/delivered, or still ongoing pregnancy [17,[22][23][24][25][26][27][28][29][30][31][32][33]36,37,[39][40][41][42][43]. While the majority of 1st trimester infection neonates had a reported status of on-going pregnancy (n=24/31: 77.4%), 4/31 (12.9%) were reported miscarriages, 1/31 (3.2%) abortion, 1 (3.2%) stillbirth and 1 (3.2%) chemical pregnancy was also noted.…”

Section: Neonatal Outcomesmentioning

confidence: 99%

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Contracting COVID-19 in the first and second trimester of pregnancy: what we know – a concise qualitative systematic review

et al. 2021

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published from January 1st to 27th of December 2020. Two independent reviewers evaluated studies using the STROBE statement in combination with the CERQual quality assessment of findings. Total 1387 articles were screened and a final 24 studies evaluated (220 1st/2nd trimesters COVID-19 pregnant women). 132/220 (60%) were symptomatic, most commonly with fever (86/220=39%) or cough (73/220=33%). Minority of studies reported complications, notably preeclampsia (2/15 patients-13%). 3 cases of maternal death were reported. Majority of neonates had unreported status concerning the outcome of pregnancy. Neonatal death occurred in 17 cases (including one chemical pregnancy, 5 miscarriages, 2 IUFD, 6 stillbirths and 3 abortions) Majority of reported mothers who contracted COVID-19 during 1st/2nd trimesters are yet to complete their pregnancy. Usually, mothers are discharged from the hospital without any serious complications, however, placental inflammation/fibrin deposition and neonatal death has been reported in a number of cases.

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Section: Pregnancy Related Complicationsmentioning

confidence: 99%

Section: Neonatal Outcomesmentioning

confidence: 99%

Contracting COVID-19 in the first and second trimester of pregnancy: what we know – a concise qualitative systematic review

et al. 2021

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Pregnancy, Viral Infection, and COVID-19

et al. 2020

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Pregnancy comprises a unique immunological condition, to allow fetal development and to protect the host from pathogenic infections. Viral infections during pregnancy can disrupt immunological tolerance and may generate deleterious effects on the fetus. Despite these possible links between pregnancy and infection-induced morbidity, it is unclear how pregnancy interferes with maternal response to some viral pathogens. In this context, the novel coronavirus (SARS-CoV-2) can induce the coronavirus diseases-2019 (COVID-19) in pregnant women. The potential risk of vertical transmission is unclear, babies born from COVID-19-positive mothers seems to have no serious clinical symptoms, the possible mechanisms are discussed, which highlights that checking the children's outcome and more research is warranted. In this review, we investigate the reports concerning viral infections and COVID-19 during pregnancy, to establish a correlation and possible implications of COVID-19 during pregnancy and neonatal's health.

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COVID-19 Infection in First Trimester of Pregnancy Marked by a Liver Cytolysis: A Case Report.

Cited by 2 publications

References 0 publications

Contracting COVID-19 in the first and second trimester of pregnancy: what we know – a concise qualitative systematic review

Contracting COVID-19 in the first and second trimester of pregnancy: what we know – a concise qualitative systematic review

Pregnancy, Viral Infection, and COVID-19

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