COVİD-19 infection in a membranous nephropathy patient treated with rituximab

Abstract

While COVID-19 pandemic continues to affect our country and most countries in the world, we have to make some changes both in our social life and our approach to healthcare. We have to struggle with the pandemic on one hand and also try to follow up and treat our patients with chronic diseases in the most appropriate way. In this period, one of our group of patients who are challenging us for follow-up and treatment are those who should start or continue to use immunosuppressive therapy. In order to contribute to the accumulation of knowledge in this area, we wanted to report a patient who was followed up with the diagnosis of COVID-19 and had been administered rituximab very recently due to a nephrotic syndrome caused by membranous nephropathy.

A case of membranous nephropathy following Pfizer–BioNTech mRNA vaccination against COVID-19

“…Our observation, together with other case reports of MN development post COVID-19 infection 2,3 and MN relapse post COVID-19 vaccine 1 , supports a possible immune dysregulation process causing loss of tolerance to certain podocyte antigens, which requires further studies to elucidate.…”

Persistent SARS-CoV-2 Infection in a Patient with Nephrotic Syndrome under Rituximab Therapy: Successful Treatment with a Combination of Remdesivir and Monoclonal Antibodies

“…Persistent SARS-CoV-2 infection may occur in immunocompromised individuals, and these patients tend to remain infectious for !3 weeks. Table 2 lists reported cases of persistent SARS-CoV-2 infection in patients under anti-CD20 therapy, including this case (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Most case reports are of malignant lymphoma or chronic lymphocytic leukemia, and rarely of other diseases.…”

“…The coronavirus disease 2019 (COVID-19) pandemic continues to affect the global population. There have been several reports of immunocompromised patients developing persistent and prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Kidneys in SARS‐CoV‐2 era: A challenge of multiple faces

“…The available literature described cases with underlying glomerular pathology exacerbated during SARS‐CoV2 infection, e.g., IgA nephropathy [74], cryoglobulinemic MPGN [75], and Membranous nephropathy [76].…”