COVID‐19 in Italian paediatric patients: The experience of a tertiary children's hospital

Romani, Lorenza; Chiurchiù, Sara; Santilli, Veronica; Bernardi, Stefania; Lombardi, Mary Haywood; Scarselli, Alessia; Villani, Alberto; Atti, Marta Luisa Ciofi degli; Campaña, Andrea; D’Argenio, Patrizia

doi:10.1111/apa.15465

Cited by 25 publications

(28 citation statements)

References 5 publications

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“…We should interpret the result with caution because the symptom data only come from two sero-surveillance studies carried out in one high school (n = 661) and six primary schools (n = 1340) in France (Crépy-en-Valois). Studies from Italy [ 41 - 43 ], Germany [ 44 ], UK [ 45 ], Turkey [ 46 ] and Sweden [ 47 ] also reported similar clinical symptoms in children. In addition to common respiratory symptoms, gastrointestinal symptoms such as diarrhoea were present in around 25% of pediatric patients [ 48 ].…”

Section: Discussionmentioning

confidence: 92%

What is the evidence for transmission of COVID-19 by children in schools? A living systematic review

Dozier

et al. 2020

Journal of Global Health

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Section: Discussionmentioning

confidence: 92%

What is the evidence for transmission of COVID-19 by children in schools? A living systematic review

Dozier

et al. 2020

Journal of Global Health

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“…Raised levels of D‐dimers were found in 17.5% of children with pneumonia and 16% of children with upper respiratory tract infections, but not in asymptomatic children 12 . Thrombocytopenia has been associated with respiratory deterioration in children, 21 more often encountered in critically ill patients and those admitted to the pediatric ICU 14,23 …”

Section: Methodsmentioning

confidence: 99%

“…Original studies published up to July 27, 2020 [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] providing data on white blood cell (WBC) abnormalities in children with COVID-19 are shown in Table 1.…”

Section: Abnormalities In the White Blood Cell Count In Children Withmentioning

confidence: 99%

Hematological manifestations of SARS‐CoV‐2 in children

Kosmeri

Koumpis

Tsabouri

et al. 2020

Pediatric Blood & Cancer

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Infection from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), though mainly a respiratory disease, can impair many systems, including causing hematological complications. Lymphopenia and hypercoagulability have been reported in adults with coronavirus disease 2019 (COVID-19) and are considered markers of poor prognosis. This review summarizes the hematological findings in children with SARS-CoV-2 infection. The majority of infected children had a normal leukocyte count, while the most common white blood cell abnormality was leukopenia. Lymphopenia, which may be a marker of severe disease, was rarer in children than in adults, possibly due to their immature immune system or due to the less severe manifestation of COVID-19 in this age group. Age may have an impact, and in neonates and infants the most common abnormality was lymphocytosis. Abnormalities of red blood cells and platelets were uncommon. Anemia and hypercoagulability were reported mainly in children presenting the novel multisystem inflammatory syndrome (MIS) associated with SARS-CoV-2.

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“…It could be due to less exposure to the external environment or to host factors, such as the different affinity and expression of their ACE2 receptors or their developing immune system [12]. For example, children seem to have reduced concentrations of proinflammatory cytokines and C-reactive protein (CRP), which could explain the lower levels of immune-mediated damage in children and their mild symptoms; moreover, the immune systems of children may be more resistant to some viruses due to their frequent exposure to respiratory infections [6,[13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…As far as the severity of clinical illness, children show a milder disease or they are asymptomatic in more than 90% of cases [6,14,15,20,21,28]. However, it is worth noting that severe manifestations have also been observed, particularly in children with comorbidities [10,14,17,22,29,30].…”

Section: Introductionmentioning

confidence: 99%

Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study

Farronato

Dolci

Boccalari

et al. 2021

IJERPH

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At the end of 2019, a new disease caused by the novel coronavirus SARS-CoV-2 appeared in Wuhan Province in China. Children seemed to be infected less frequently than adults, and family clusters seemed to play an important role in the spread of the pandemic. The aim of this study is to evaluate the serological profile of children and young adults between 4 and 16 years of age in order to assess the transmission patterns of COVID-19 between cohabitants. The subjects lived with at least one cohabitant who tested positive for the disease using a nasopharyngeal swab. To avoid contact with the disease, families were interviewed by telephone. Forty-nine children and adolescents with a mean age of 11 years were then subjected to a rapid lateral flow chromatographic test. Of them, seven (14.3%) were immunoglobulin G (IgG)-positive, and four (8.2%) were immunoglobulin M (IgM)-positive. In total, 16.3% of the tested sample had antibodies against SARS-CoV-2: this may confirm the lower vulnerability of children to COVID-19, despite the small sample size. The time from the negativization of the cohabitant until the test day may have influenced the results, especially when this timeframe is wide.

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COVID‐19 in Italian paediatric patients: The experience of a tertiary children's hospital

Cited by 25 publications

References 5 publications

What is the evidence for transmission of COVID-19 by children in schools? A living systematic review

What is the evidence for transmission of COVID-19 by children in schools? A living systematic review

Hematological manifestations of SARS‐CoV‐2 in children

Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study

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