COVID-19 Dynamic Computed Tomography (CT) Performance and Observation of Some Laboratory Indicators

Jiang, Xiangsen; Yin, Zhicong; Wang, Tao; Zhai, Nailiang; Lu, Feng; Zhan, Chunhua; Han, Qizheng; Feng, Changjiang

doi:10.12659/msm.924403

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…Fibrous lesions appeared with a low frequency (17.68%) in 0-4 days, and 26.12% in 10-14 days, which is higher than that in other signs. The frequency of fibrotic lesions in the disease outcome of this study was higher, which may be due to different interpretations: some fiber streaks disappeared in the later period, and two cases of streaks were reported to be absorbed in 19 days (Jiang et al, 2020). Guan et al (2020) reported a delay in the changes on CT and evidence of lesion absorption.…”

Section: Accompanying Signs and Evolutionmentioning

confidence: 51%

An Illustrated Guide to the Imaging Evolution of COVID in Non-Epidemic Areas of Southeast China

Wang

Jiaerken

et al. 2021

Front. Mol. Biosci.

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Purpose: By analyzing the CT manifestations and evolution of COVID in non-epidemic areas of southeast China, analyzing the developmental abnormalities and accompanying signs in the early and late stages of the disease, providing imaging evidence for clinical diagnosis and identification, and assisting in judging disease progression and monitoring prognosis.Methods: This retrospective and multicenter study included 1,648 chest CT examinations from 693 patients with laboratory-confirmed COVID-19 infection from 16 hospitals of southeast China between January 19 and March 27, 2020. Six trained radiologists analyzed and recorded the distribution and location of the lesions in the CT images of these patients. The accompanying signs include crazy-paving sign, bronchial wall thickening, microvascular thickening, bronchogram sign, fibrous lesions, halo and reverse-halo signs, nodules, atelectasis, and pleural effusion, and at the same time, they analyze the evolution of the abovementioned manifestations over time.Result: There were 1,500 positive findings in 1,648 CT examinations of 693 patients; the average age of the patients was 46 years, including 13 children; the proportion of women was 49%. Early CT manifestations are single or multiple nodular, patchy, or flaky ground-glass–like density shadows. The frequency of occurrence of ground-glass shadows (47.27%), fibrous lesions (42.60%), and microvascular thickening (40.60%) was significantly higher than that of other signs. Ground-glass shadows increase and expand 3–7 days after the onset of symptoms. The distribution and location of lesions were not significantly related to the appearance time. Ground-glass shadow is the most common lesion, with an average absorption time of 6.2 days, followed by consolidation, with an absorption time of about 6.3 days. It takes about 8 days for pure ground-glass lesions to absorb. Consolidation change into ground glass or pure ground glass takes 10–14 days. For ground-glass opacity to evolve into pure ground-glass lesions, it takes an average of 17 days. For ground-glass lesions to evolve into consolidation, it takes 7 days, pure ground-glass lesions need 8 days to evolve into ground-glass lesions. The average time for CT signs to improve is 10–15 days, and the first to improve is the crazy-paving sign and nodules; while the progression of the disease is 6–12 days, the earliest signs of progression are air bronchogram signs, bronchial wall thickening, and bronchiectasis. There is no severe patient in this study.Conclusion: This study depicts the CT manifestation and evolution of COVID in non-epidemic origin areas, and provides valuable first-hand information for clinical diagnosis and judgment of patient’s disease evolution and prediction.

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Section: Accompanying Signs and Evolutionmentioning

confidence: 51%

An Illustrated Guide to the Imaging Evolution of COVID in Non-Epidemic Areas of Southeast China

Wang

Jiaerken

et al. 2021

Front. Mol. Biosci.

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“…32 Moreover, correlating dynamic changes seen on a CT of the lung with laboratory test results could provide more information and help in the diagnosis and treatment of COVID-19 patient. 33 Furthermore, the utility of CT was further noted in distinguishing COVID-19 from other viral types of pneumonia. It also provided rapid diagnostic results as to whether patients were COVID-19 positive or negative, based on CT image features.…”

Section: Resultsmentioning

confidence: 99%

The Role and Challenges of Clinical Imaging During COVID-19 Outbreak

Alhasan

Hasaneen²

2021

Journal of Diagnostic Medical Sonography

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Objective: The Radiology department played a crucial role in detecting and following up with the COVID-19 disease during the pandemic. The purpose of this review was to highlight and discuss the role of each imaging modality, in the radiology department, that can help in the current pandemic and to determine the challenges faced by staff and how to overcome them. Materials and Methods: A literature search was performed using different databases, including PubMed, Google scholar, and the college electronic library to access 2020 published related articles. Results: A chest computed tomogram (CT) was found to be superior to a chest radiograph, with regards to the early detection of COVID-19. Utilizing lung point of care ultrasound (POCUS) with pediatric patients, demonstrated excellent sensitivity and specificity, compared to a chest radiography. In addition, lung ultrasound (LUS) showed a high correlation with the disease severity assessed with CT. However, magnetic resonance imaging (MRI) has some limiting factors with regard to its clinical utilization, due to signal loss. The reported challenges that the radiology department faced were mainly related to infection control, staff workload, and the training of students. Conclusion: The choice of an imaging modality to provide a COVID-19 diagnosis is debatable. It depends on several factors that should be carefully considered, such as disease stage, mobility of the patient, and ease of applying infection control procedures. The pros and cons of each imaging modality were highlighted, as part of this review. To control the spread of the infection, precautionary measures such as the use of portable radiographic equipment and the use of personal protective equipment (PPE) must be implemented.

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“…Abdominal microcirculatory disorders, as well as central or peripheral pulmonary embolism was also found in severe cases of COVID-19. As the disease worsened, the laboratory parameter of fibrinogen was increased to some varying degree, and multiple lesions in CT scan were progressively noticed [38,39]. Imaging modality which is greatly beneficial in detecting thrombotic events occurrence in these cases in addition to lung CT scan, is contrast-enhanced ultrasound (CEUS).…”

Section: Discussionmentioning

confidence: 99%

Elevated fibrinogen and fibrin degradation product are associated with poor outcome in COVID-19 patients: A meta-analysis

Nugroho

Wardhana

Mulia

et al. 2021

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INTRODUCTION: COVID-19 is a systemic infection with a significant impact on coagulation which manifests in thromboembolism. There is an unknown relationship of which coagulation profile parameter at presentation has an association with poor outcome in COVID-19. OBJECTIVE: This meta-analysis aimed to determine the relationship between fibrinogen and FDP with poor outcome in COVID-19 patients. METHODS: A systematic search of all observational studies or trials involving adult patients with COVID-19 that had any data fibrinogen or FDP on admission was carried out using the PubMed, Science Direct, Scopus, ProQuest, and MedRxiv databases. We assessed the methodological quality assessment using the NIH Quality Assessment Tool. We performed random-effects inverse-variance weighting analysis using mean difference (MD). RESULTS: A total of 17 studies (1,654 patients) were included in this meta-analysis. It revealed a higher mean of fibrinogen levels on admission in patients with severe case compared to those with non-severe case (MD = 0.69, [95% CI: 0.44 to 0.94], p < 0.05; I2 = 72%, p < 0.05). Non-survivor group had a pooled higher mean difference of fibrinogen values on admission (MD = 0.48 [95% CI: 0.13 to 0.83], p < 0.05; I2 = 38%, p = 0.18). Higher FDP on admission was found in poor outcome (composite of severity, critically ill, and mortality) compared to good outcome (4 studies, MD = 4.84 [95% CI: 0.75 to 8.93], p < 0.05; I2 = 86%, p < 0.05). CONCLUSION: Elevated fibrinogen and FDP level on admission were associated with an increase risk of poor outcome in COVID-19 patients.

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COVID-19 Dynamic Computed Tomography (CT) Performance and Observation of Some Laboratory Indicators

Cited by 8 publications

References 6 publications

An Illustrated Guide to the Imaging Evolution of COVID in Non-Epidemic Areas of Southeast China

An Illustrated Guide to the Imaging Evolution of COVID in Non-Epidemic Areas of Southeast China

The Role and Challenges of Clinical Imaging During COVID-19 Outbreak

Elevated fibrinogen and fibrin degradation product are associated with poor outcome in COVID-19 patients: A meta-analysis

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