MPS in AHP students are prevalent and statistically higher among females. Students are advised to adhere to different conservative precautions and follow prevention programs. Future studies are needed to assess actual mechanisms causing MPS among AHP students and designing effective prevention programs specific to AHP students.
Small animal imaging provides diverse methods for evaluating tumor growth and acute response to therapy. This study compared the utility of non-invasive optical and ultrasound imaging to monitor growth of three diverse human tumor xenografts (brain U87-luc-mCherry, mammary MCF7-luc-mCherry, and prostate PC3-luc) growing in nude mice. Bioluminescence imaging (BLI), fluorescence imaging (FLI), and Power Doppler ultrasound (PD US) were then applied to examine acute vascular disruption following administration of arsenic trioxide (ATO).During initial tumor growth, strong correlations were found between manual caliper measured tumor volume and FLI intensity, BLI intensity following luciferin injection, and traditional B-mode US. Administration of ATO to established U87 tumors caused significant vascular shutdown within 2 hrs at all doses in the range 5 to 10 mg/kg in a dose dependant manner, as revealed by depressed bioluminescent light emission. At lower doses substantial recovery was seen within 4 hrs. At 8 mg/kg there was >85% reduction in tumor vascular perfusion, which remained depressed after 6 hrs, but showed some recovery after 24 hrs. Similar response was observed in MCF7 and PC3 tumors. Dynamic BLI and PD US each showed similar duration and percent reductions in tumor blood flow, but FLI showed no significant changes during the first 24 hrs.The results provide further evidence for comparable utility of optical and ultrasound imaging for monitoring tumor growth, More specifically, they confirm the utility of BLI and ultrasound imaging as facile assays of the vascular disruption in solid tumors based on ATO as a model agent.
The advancement of technology remained an immersive interest for humankind throughout the past decades. Tech enterprises offered a stream of innovation to address the universal healthcare concerns. The novel coronavirus holds a substantial foothold of planet earth which is combatted by digital interventions across afflicted geographical boundaries and territories. This study aims to explore the trends of modern healthcare technologies and Artificial Intelligence (AI) during COVID-19 crisis, define the concepts and clinical role of AI in the mitigation of COVID-19, investigate and correlate the efficacy of AI-enabled technology in medical imaging during COVID-19 and determine advantages, drawbacks, and challenges of artificial intelligence during COVID-19 pandemic.
The paper applied systematic review approach using a deliberated research protocol and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart.
Digital technologies can coordinate COVID-19 responses in a cascade fashion that extends from the clinical care facility to the exterior of the pending viral epicenter. With cases of healthcare robotics, aerial drones, and the internet of things as evidentiary examples. PCR tests and medical imaging are the frontier diagnostics of COVID-19. Computed tomography helped to correct the accuracy variation of PCR tests at a clinical sensitivity of 98%. Artificial intelligence can enable autonomous COVID-19 responses using techniques like machine learning.
Technology could be an endless system of innovation and opportunities when sourced effectively. Scientists can utilize technology to resolve global concerns challenging the history of tangible possibility. Digital interventions have enhanced the responses to COVID-19, magnified the role of medical imaging amid the COVID-19 crisis and have exposed healthcare professionals to the opportunity of contactless care.
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