Covid-19: current knowledge, disease potential, prevention and clinical advances

Abstract

The top priority of any nation is to lead the nation towards prosperity, progress, and economic growth, confronting several challenges and concerns arisen from global situations. The sudden outbreak of any disease defies the health care systems and economy of nations. COVID-19 is one of the viral diseases which broke out in Wuhan city of China in 2019. COVID-19 outbreak intermittently prevailed all over the world. It exposes the fragility of the established health care systems across the world in spite of comprising modern science and technology. Unfortunately, there is no chemotherapeutic agent in the regimen of antiviral drugs or no vaccine available to curb this infectious disease. As a consequence, this deadly infection has prevailed all over the world. The antiviral drugs used for viral diseases excluding COVID-19 infection are Ramdesvir, Favipiravir, and Ribavarin, and antimalarial agents (Chloroquine & Hydroxychloroquine) are being administered to the patients for redemption of this infection. Fortunately, these existing drugs have been found clinically active and are being used. In this review, we present the current scenario and status of epidemiology, diagnosis, treatment, vaccine development for COVID-19, and its impact on the socio-economic structure.

COVID-19 Knowledge, Risk Perception, and Precautionary Behavior Among Nigerians: A Moderated Mediation Approach

“…All across the globe, the most effective way of delaying the spread of infections, especially in times when vaccines are not yet available, has been the adoption of precautionary behaviors (Tang et al, 2012;Ebrahim and Memish, 2020;Sjödin et al, 2020). However, the challenge often is the knowledge and awareness level of individuals about the infectiousness of diseases (Hassan et al, 2017;Alam et al, 2020) and whether such knowledge will translate into precautionary behavior (Ho et al, 2013;Cain et al, 2018;Li et al, 2020).…”

A chronicle of temperature and SARS-CoV-2 viability: a retrospective study

“…Although the direct droplet transmission is an important route of further infection, but the role of fomites contamination contributes a significant role in continued transmission in the nosocomial setting, that happens quite often in spite of much awareness and precaution. 4,5,7 As the temperature seemed to be an essential component in the viability of COVID-19 virus and its dissemination since its emergence, so we focus on the apprehension of the correspondence to temperature and transmission of COVID-19 infection from the data available between from Jan 1, 2020, to (Jun 24, 2020) and we get the following results:…”

“…Therefore it is the utmost importance to halt any additional spread of this serious illness in the public and healthcare sites. 4 Generally, the flu causing virus, i.e. influenza virus's outer membrane is composed of lipids molecules, and in the cold season, virus's outer covering becomes rubbery and becomes more protective that can withstand travel from person to person.…”

As funções da equipe pluridisciplinar no cuidado da covid-19 / The functions of the multidisciplinary team in the care of covid-19

“…(1) Seu período de incubação varia de 2 a 14 dias, sendo, em média, de 5 dias. (1,2) Os sinais e sintomas iniciais são semelhantes e indistinguíveis de outros agentes virais, como febre, mialgia, astenia e fadiga. Entretanto chamam atenção a pneumonia grave e a disfunção orgânica, principalmente em pacientes acima de 60 anos ou aqueles com comorbidades, pois correlacionam-se ao alto índice de mortalidade.…”

“…Entretanto chamam atenção a pneumonia grave e a disfunção orgânica, principalmente em pacientes acima de 60 anos ou aqueles com comorbidades, pois correlacionam-se ao alto índice de mortalidade. (1,2) Assim sendo, a principal ferramenta de diagnóstico laboratorial é a reação de cadeia da polimerase em tempo real (RT-PCR) através da análise de amostras respiratórias, coletadas a partir de swabs nasofaríngeos. (3) Os testes sorológicos detectam os anticorpos IgM e IgG, fornecendo informações sobre as respostas imunes inata e adaptativa.…”