In urban areas, air pollution is one of the most serious global environmental issues. Using time-series approaches, this study looked into the validity of the relationship between air pollution and COVID-19 hospitalization. This time series research was carried out in the state of Kuwait; stationarity test, cointegration test, Granger causality and stability test, and test on multivariate time-series using the Vector Error Correction Model (VECM) technique. The findings reveal that the concentration rate of air pollutants ($$\hbox {O}_3$$
O
3
, $$\hbox {SO}_2$$
SO
2
, $$\hbox {NO}_2$$
NO
2
, $$\hbox {CO}$$
CO
, and $$\hbox {PM}_{10}$$
PM
10
) has an effect on COVID-19 admitted cases via Granger-cause. The Granger causation test shows that the concentration rate of air pollutants ($$\hbox {O}_3$$
O
3
, $$\hbox {PM}_{10}$$
PM
10
, $$\hbox {NO}_2$$
NO
2
, temperature and wind speed) influences and predicts the COVID-19 admitted cases. The findings suggest that sulfur dioxide ($$\hbox {SO}_2$$
SO
2
), $$\hbox {NO}_2$$
NO
2
, temperature, and wind speed induce an increase in COVID-19 admitted cases in the short term according to VECM analysis. The evidence of a positive long-run association between COVID-19 admitted cases and environmental air pollution might be shown in the cointegration test and the VECM. There is an affirmation that the usage of air pollutants ($$\hbox {O}_3$$
O
3
, $$\hbox {SO}_2$$
SO
2
, $$\hbox {NO}_2$$
NO
2
, $$\hbox {CO}$$
CO
, and $$\hbox {PM}_{10}$$
PM
10
) has a significant impact on COVID-19-admitted cases’ prediction and its explained about 24% of increasing COVID-19 admitted cases in Kuwait.