COVID‐19‐associated cutaneous manifestations: does human herpesvirus 6 play an aetiological role?

Abadías‐Granado, Isabel; Navarro‐Bielsa, Alba; Morales-Callaghan, Ana María; Roc, Lourdes; Suso-Estívalez, Catalina; Povar-Echeverría, Marina; Gilaberte, Yolanda

doi:10.1111/bjd.19806

Cited by 18 publications

(19 citation statements)

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“…COVID-19 infection is characterized by acquired lymphopenia, which is a predictor of disease severity (Terpos et al, 2020). This, in addition to the hypogammaglobulinemia seen in a subset of patients (Dupont et al, 2020), creates an acquired immunocompromised state during COVID-19 infection as evidenced by an increased susceptibility to secondary bacterial infections and viral reactivation (Li et al, 2020;Drago et al, 2020;Abadías-Granado et al, 2021). HHV6 myelitis is a rare disorder that is almost exclusively seen in immunocompromised patients such as post bone marrow transplantation and in the setting of HIV infection (Shiroshita et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Several cases of post-COVID-19 myelitis have been reported often with negative SARS-CoV-2 PCR in the CSF and good response to corticosteroids, suggesting an immune-mediated etiology (Table 1). An increased incidence of HHV6-related diseases such as Kawasaki disease and pityriasis rosea has been reported during the COVID-19 pandemic, suggesting a link between COVID-19 immune dysfunction and reactivation of HHV6 (Dursun, 2020;Drago et al, 2020, Abadías-Granado et al, 2021. Interestingly, the HHV6 and SARS-CoV-2 viruses have each been separately linked to MOG-IgG positive transverse myelitis (Zhou et al, 2020 andVieira et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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COVID-19, HHV6 and MOG antibody: A perfect storm

Jumah

Rahman

Figgie

et al. 2021

Journal of Neuroimmunology

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Background: Serious neurological complications of SARS-CoV-2 are increasingly being recognized. Case: We report a novel case of HHV6 myelitis with parainfectious MOG-IgG in the setting of COVID-19-induced lymphopenia and hypogammaglobulinemia. The patient experienced complete neurological recovery with gancyclovir, high dose corticosteroids, and plasma exchange. To our knowledge, this is the first case of HHV6 reactivation in the central nervous system in the setting of COVID19 infection and the first case of MOG-IgG myelitis in the setting of SARS-CoV-2 and HHV6 coinfection. Conclusion: Patients with neurological manifestations in the setting of COVID19-related immunodeficiency should be tested for opportunistic infections including HHV6. Viral infection is a known trigger for MOG-IgG and therefore this antibody should be checked in patients with SARS-CoV-2 associated demyelination.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

COVID-19, HHV6 and MOG antibody: A perfect storm

Jumah

Rahman

Figgie

et al. 2021

Journal of Neuroimmunology

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Section: Sars-cov-2 and Ms-associated Viruses: Partners In Crime?mentioning

confidence: 99%

“…Evidence on HHV-6 reactivation during SARS-CoV-2 infection is less solid, and the Herpesvirus is mainly associated to COVID-19 dermatological manifestations (127). Nonetheless, a neurological event associated to SARS-CoV-2/HHV6 interaction was described by Jumah et al (128): a 61-year-old man experiencing lymphopenia and hypogammaglobulinemia during COVID-19 developed a para-infectious acute myelitis.…”

Section: Sars-cov-2 and Ms-associated Viruses: Partners In Crime?mentioning

confidence: 99%

Multiple Sclerosis and SARS-CoV-2: Has the Interplay Started?

et al. 2021

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Current knowledge on Multiple Sclerosis (MS) etiopathogenesis encompasses complex interactions between the host’s genetic background and several environmental factors that result in dysimmunity against the central nervous system. An old-aged association exists between MS and viral infections, capable of triggering and sustaining neuroinflammation through direct and indirect mechanisms. The novel Coronavirus, SARS-CoV-2, has a remarkable, and still not fully understood, impact on the immune system: the occurrence and severity of both acute COVID-19 and post-infectious chronic illness (long COVID-19) largely depends on the host’s response to the infection, that echoes several aspects of MS pathobiology. Furthermore, other MS-associated viruses, such as the Epstein-Barr Virus (EBV) and Human Endogenous Retroviruses (HERVs), may enhance a mechanistic interplay with the novel Coronavirus, with the potential to interfere in MS natural history. Studies on COVID-19 in people with MS have helped clinicians in adjusting therapeutic strategies during the pandemic; similar efforts are being made for SARS-CoV-2 vaccination campaigns. In this Review, we look over 18 months of SARS-CoV-2 pandemic from the perspective of MS: we dissect neuroinflammatory and demyelinating mechanisms associated with COVID-19, summarize pathophysiological crossroads between MS and SARS-CoV-2 infection, and discuss present evidence on COVID-19 and its vaccination in people with MS.

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“…Les escarres et les lésions nécrotiques ou purpuriques semblent plus fréquentes chez les patients ventilés et de mauvais pronostic [ 18 ]. D’autres études ont souligné que les toxidermies, les réactivations du virus d’Epstein-Barr (EBV) (82 % dans une série de 34 patients en réanimation), cytomégalovirus (CMV) et herpèsvirus humain 6 (HHV6) (22 % dans 2 études) sont très fréquentes chez les hospitalisés pour COVID et pourraient expliquer certaines éruptions [ [20] , [21] , [22] ]. Celles observées en ville sont sémiologiquement superposables à celles des hospitalisés, avec cependant moins de lésions nécrotiques et livédoïdes [ [23] , [24] ].…”

Section: Covid Et Peauunclassified

Quoi de neuf en dermatologie clinique ?

Senet

2021

Annales de Dermatologie et de Vénéréologie - FMC

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COVID‐19‐associated cutaneous manifestations: does human herpesvirus 6 play an aetiological role?

Cited by 18 publications

References 8 publications

COVID-19, HHV6 and MOG antibody: A perfect storm

COVID-19, HHV6 and MOG antibody: A perfect storm

Multiple Sclerosis and SARS-CoV-2: Has the Interplay Started?

Quoi de neuf en dermatologie clinique ?

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