COVID-19 and peripheral arterial complications in people with diabetes and hypertension: A systematic review

Rastogi, Ashu; Dogra, Himika; Jude, Edward B.

doi:10.1016/j.dsx.2021.102204

Cited by 11 publications

(6 citation statements)

References 48 publications

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“…The hypercoagulable state is more frequent in elderly COVID‐19 patients. 133 COVID-19 patients with hypertension or diabetes mellitus are more likely to suffer lower extremity complications, 134 and coagulopathy is a major extrapulmonary risk factor for mortality in hospitalized COVID-19 with type 2 diabetes rather than acute kidney injury (AKI) and acute cardiac injury. 135…”

Section: Pathogenesis Of Sars-cov-2 Infectionmentioning

confidence: 99%

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Ning

Wang

et al. 2022

Sig Transduct Target Ther

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The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19.

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Section: Pathogenesis Of Sars-cov-2 Infectionmentioning

confidence: 99%

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Ning

Wang

et al. 2022

Sig Transduct Target Ther

View full text Add to dashboard Cite

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“…Complications pertaining to the vascular system, such as the cytokine storm that precipitates DIC, and thrombotic microvascular injury affecting the medium- and small-size vessels (coronary heart disease, lung thromboembolism, stroke, mesenteric ischemia, renal-artery thrombosis, and limb-artery thrombosis) are characteristic of COVID-19. Cutaneous lesions associated with arterial and venous thrombotic events appear as gangrene of the limbs [ 127 ].…”

Section: Discussionmentioning

confidence: 99%

The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases

Szilveszter¹,

Pál

Simon-Szabó

et al. 2023

IJMS

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The course of COVID-19 is highly dependent on the associated cardiometabolic comorbidities of the patient, which worsen the prognosis of coronavirus infection, mainly due to systemic inflammation, endothelium dysfunction, and thrombosis. A search on the recent medical literature was performed in five languages, using the PubMed, Embase, Cochrane, and Google Scholar databases, for the review of data regarding the management of patients with a high risk for severe COVID-19, focusing on the associated coagulopathy. Special features of COVID-19 management are presented, based on the underlying conditions (obesity, diabetes mellitus, and cardiovascular diseases), emphasizing the necessity of a modern, holistic approach to thromboembolic states. The latest findings regarding the most efficient therapeutic approaches are included in the article, offering guidance for medical professionals in severe, complicated cases of SARS-CoV-2 infection. We can conclude that severe COVID-19 is closely related to vascular inflammation and intense cytokine release leading to hemostasis disorders. Overweight, hyperglycemia, cardiovascular diseases, and old age are important risk factors for severe outcomes of coronavirus infection, involving a hypercoagulable state. Early diagnosis and proper therapy in complicated SARS-CoV-2-infected cases could reduce mortality and the need for intensive care during hospitalization in patients with cardiometabolic comorbidities.

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“…Peripheral gangrene in COVID-19 patients is more likely to happen with prior endothelial dysfunction secondary to hypertension and diabetes. Overall, 30.1% of patients died, and 11.8% required amputations [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Right Foot Trans Metatarsal Amputation Following COVID-19 Infection

Sanhueza-Martinez¹,

Brar²,

Yabit³

et al. 2022

Cureus

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A 60-year-old male patient with a prior coronavirus disease 2019 (COVID-19) pneumonia diagnosis presented with a right foot ulcer. The ulcer progressed to osteomyelitis of his right fifth metatarsal with eventual amputation and resection of the affected digit. The infection recurred two months later and spread to the right fourth metatarsal and gangrene, leading to the amputation and partial metatarsal head resection of the fourth toe. A month later, the infection recurred for a second time and a decision to perform a right trans metatarsal amputation of the foot was evaluated to avoid further progression of the infection and the need for more invasive surgical intervention.

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COVID-19 and peripheral arterial complications in people with diabetes and hypertension: A systematic review

Cited by 11 publications

References 48 publications

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases

Right Foot Trans Metatarsal Amputation Following COVID-19 Infection

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