COVID-19 and chronic obstructive pulmonary disease: what is known about the unknown

Овсянников, Евгений Сергеевич; Авдеев, С. Н.; Будневский, А. В.; Дробышева, Елена Сергеевна; Кравченко, А Я

doi:10.21292/2075-1230-2021-99-2-6-15

Cited by 6 publications

(1 citation statement)

References 55 publications

(11 reference statements)

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“…Moreover, in COPD, supraventricular arrhythmias are observed in 77%, AF was observed in 8% of patients, and the risk of AF hospitalization was higher among patients with a low FEV1

60% [ 35 ]. Some researchers [ 36 ] presented a review of 60 literature sources regarding the comorbidity of COVID-19 and COPD. It is evident that COPD patients have increased the expression of the angiotensin-converting enzyme 2 receptor in the lungs, which may contribute to a greater susceptibility to COVID-19.…”

Section: Resultsmentioning

confidence: 99%

Features of Atrial Fibrillation Pathogenesis and Prognosis in Chronic Obstructive Pulmonary Patients during the COVID-19 Pandemic

Hazarapetyan¹,

Zelveian²,

Grigoryan³

2023

Rev. Cardiovasc. Med.

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Background: Atrial fibrillation (AF) is observed in arterial hypertension, heart failure, ischemic heart disease, and pulmonary pathology, particularly, chronic obstructive pulmonary disease (COPD). COPD in turn is a risk factor for developing these cardiovascular diseases and various arrhythmias. In the coronavirus disease (COVID) situation, such comorbid patients are the most vulnerable group with a high risk of adverse outcomes. The relevance of the relationship between COPD and coronavirus infection is explained by the similarity of clinical and pathophysiological manifestations, creating more difficulties in diagnosing and determining rational treatment. The aim of the current study is to explore the role COPD plays in the onset and progression of AF, especially in the situation of COVID-19. Methods: We searched PubMed databases and included studies with information on comorbid patients suffering from COPD and AF, as well as similar patients in the context of COVID-19. Results: A modern view on the problem of comorbidity of COPD and AF is presented. In the presence of cardiorespiratory comorbidity, symptoms of mutual worsening of the clinical course are observed, due to the commonality of some links of pathogenesis, including hypoxia, hemodynamic disturbances, activation of the sympathoadrenal system, systemic inflammation, and development of fibrosis, leading to myocardial remodeling, a decrease in the effectiveness of the therapy, and a worsening prognosis, especially in the context of COVID-19. Conclusions: The results of a study of the features of the pathogenesis and course of AF in COPD are presented, as well as the formation and progression of this comorbid pathology in the context of the COVID-19 pandemic.

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“…Moreover, in COPD, supraventricular arrhythmias are observed in 77%, AF was observed in 8% of patients, and the risk of AF hospitalization was higher among patients with a low FEV1

Section: Resultsmentioning

confidence: 99%

Features of Atrial Fibrillation Pathogenesis and Prognosis in Chronic Obstructive Pulmonary Patients during the COVID-19 Pandemic

Hazarapetyan¹,

Zelveian²,

Grigoryan³

2023

Rev. Cardiovasc. Med.

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Melatonin effects in COVID-19

Budnevsky¹,

Авдеев²,

Ovsyannikov³

et al. 2021

Profil. med.

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Forecast of the socioeconomic burden of COPD in the Russian Federation in 2022

Drapkina

Kontsevaya

Муканеева

et al. 2022

Pulʹmonologiâ (Mosk.)

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Chronic obstructive pulmonary disease (COPD) is characterized by a high level of morbidity and mortality and is associated with significant social and economic losses for the health care system and society.Aim. To predict the socio-economic burden of COPD in the Russian Federation in 2022, including the cost of drug treatment.Methods. The socio-economic burden of COPD in the Russian Federation in 2022 was predicted with and without taking into account the impact of COVID-19. The analysis of the cost of illness included the calculation of direct and indirect costs due to COPD. Data of Federal State Statistics Service, the State Guarantee Program of Free Medical Care for Citizens of Russian Federation, and data from the regional register of drug treatment of patients with COPD were used. Costs of medical care (ambulatory, hospital, and emergency care) were calculated based on compulsory health insurance tariffs. The disability benefits payments were calculated based on number of disabled persons and the amount of the disability benefit in each group. Indirect costs (or economic losses) included losses from products which were not produced due to disability and premature mortality of working-aged adults.Results. The predicted total economic losses due to COPD in 2022 will be 428.5 billion rubles when taking into account the impact of COVID-19, and 378.9 billion rubles when not accounting for COVID-19. Losses in the economy due to decreased labor productivity because of premature deaths (86%) are major part of the main burden. The cost of drug therapy for patients with COPD in outpatient settings will amount to over 17 billion rubles.Conclusion. Potential economic burden of COPD in 2022 depends on the incidence of COVID-19 and could be 0.34% of the GDP. Priority should be given to measures aimed at preventing the occurrence of COPD by correcting risk factors in the population, early diagnosis, slowing the progression of the disease and preventing exacerbations. Prevention of respiratory infections including COVID-19 in patients with COPD plays a special role.

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COVID-19 and chronic obstructive pulmonary disease: what is known about the unknown

Cited by 6 publications

References 55 publications

Features of Atrial Fibrillation Pathogenesis and Prognosis in Chronic Obstructive Pulmonary Patients during the COVID-19 Pandemic

Features of Atrial Fibrillation Pathogenesis and Prognosis in Chronic Obstructive Pulmonary Patients during the COVID-19 Pandemic

Melatonin effects in COVID-19

Forecast of the socioeconomic burden of COPD in the Russian Federation in 2022

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