COVID-19 and Alzheimer’s Disease: A Literature Review

Hardan, Louis; Filtchev, Dimitar; Kassem, Ratiba; Bourgi, Rim; Łukomska−Szymańska, Monika; Tarhini, Hassan; Salloum-Yared, Fouad; Mancino, Davide; Kharouf, Naji; Haïkel, Youssef

doi:10.3390/medicina57111159

Cited by 24 publications

(27 citation statements)

References 53 publications

(70 reference statements)

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“…Coronaviruses are RNA viruses that cause common respiratory infections in humans, and they are an infectious agent responsible for mild respiratory tract infections [ 1 ]. Since December 2019, the coronavirus “SARS-CoV-2”, which causes severe bilateral pneumonia, has spread throughout the world, starting in Wuhan, China.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Practicability of Biosynex Antigen Self-Test COVID-19 AG+ for the Detection of SARS-CoV-2 Nucleocapsid Protein from Self-Collected Nasal Mid-Turbinate Secretions in the General Public in France

Tonen‐Wolyec

Dupont²,

Awaida³

et al. 2021

Diagnostics

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Due to their ease-of-use, lateral flow assay SARS-CoV-2 antigen-detecting rapid diagnostic tests could be suitable candidates for antigen-detecting rapid diagnostic self-test (Ag-RDST). We evaluated the practicability of the Ag-RDST BIOSYNEX Antigen Self-Test COVID-19 Ag+ (Biosynex Swiss SA, Freiburg, Switzerland), using self-collected nasal secretions from the turbinate medium (NMT), in 106 prospectively included adult volunteers living in Paris, France. The majority of the participants correctly understood the instructions for use (94.4%; 95% confidence interval (CI): 88.3–97.4), showing a great ability to perform the entire self-test procedure to obtain a valid and interpretable result (100%; 95% CI: 96.5–100), and demonstrated the ability to correctly interpret test results (96.2%; 95% CI: 94.2–97.5) with a high level of general satisfaction. About one in eight participants (# 15%) needed verbal help to perform or interpret the test, and only 3.8% of test results were misinterpreted. By reference to multiplex real-time RT-PCR, the Ag-RDST showed 90.9% and 100% sensitivity and specificity, respectively, and high agreement (98.1%), reliability (0.94), and accuracy (90.9%) to detect SARS-CoV-2 antigen. Taken together, our study demonstrates the high usability and accuracy of BIOSYNEX Antigen Self-Test COVID-19 Ag+ for supervised self-collected NMT sampling in an unselected adult population living in France.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Practicability of Biosynex Antigen Self-Test COVID-19 AG+ for the Detection of SARS-CoV-2 Nucleocapsid Protein from Self-Collected Nasal Mid-Turbinate Secretions in the General Public in France

Tonen‐Wolyec

Dupont²,

Awaida³

et al. 2021

Diagnostics

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“…Finally, the profound changes in the relationship between patients and caregivers may lead to feelings of frustration, despair, and anger. The coronavirus pandemic, with regard to the restrictive measures, could have made these things worse [16,17].…”

Section: Introductionmentioning

confidence: 99%

How COVID-19 Has Affected Caregivers’ Burden of Patients with Dementia: An Exploratory Study Focusing on Coping Strategies and Quality of Life during the Lockdown

Maggio

Rosa

Calatozzo

et al. 2021

JCM

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COVID-19 has caused a public and international health emergency, leading to isolation and social distancing. These restrictions have had a significant impact on the caregivers of people with dementia, increasing the burden of patient management. The purpose of this study was to investigate the stress perceived by caregivers of patients with Alzheimer’s disease (AD) during the pandemic. We used a cross-sectional survey design to evaluate the caregivers’ psychological responses and coping strategies. Eighty-four caregivers of patients with a diagnosis of AD were involved in this study by completing an online questionnaire. They presented a high perception of stress (the Perceived Stress Scale mean ± DS: 33.5 ± 4.5), and their high burden in caring was mainly related to physical difficulties (Caregiver Burden Inventory–Physical Burden mean ± DS: 15.0 ± 2.1) and perception of loss of time (Caregiver Burden Inventory–Time-dependence Burden mean ± DS: 16.5 ± 1,4). Moreover, caregivers perceived their quality of life as very low (Short Form-12 Health Survey Physical mean ± DS: 13.5 ± 2.7; Short Form-12 Health Survey Mental Health mean ± DS: 16.4 ± 4.2). Finally, we found that participants mostly used dysfunctional coping strategies, such as avoidance strategies (Coping Orientation to Problem Experiences–Avoidance Strategies mean ± DS: 39.5 ± 7.1), but these strategies did not affect the stress level of caregivers. Given that caregivers present a high burden and stress, innovative tools could be a valuable solution to investigate and support their emotional and behavioral status during difficult periods, such as the COVID-19 pandemic.

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“…COVID-19 can cause a more serious infection in older patients with dementia, resulting in more severe symptoms. Although exact estimates of AD-related death are not yet available, AD patients have a higher frequency of emergency room visits, hospitalization, and mortality by COVID-19 infection than healthy aged adults ( Hardan et al, 2021 ).…”

Section: Impact Of Covid-19 On Neurological Diseasesmentioning

confidence: 99%

The Impact of COVID-19 On Comorbidities: A Review Of Recent Updates For Combating It

Malik

Ahmed

Shinde

et al. 2022

Saudi Journal of Biological Sciences

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COVID-19 and Alzheimer’s Disease: A Literature Review

Cited by 24 publications

References 53 publications

Evaluation of the Practicability of Biosynex Antigen Self-Test COVID-19 AG+ for the Detection of SARS-CoV-2 Nucleocapsid Protein from Self-Collected Nasal Mid-Turbinate Secretions in the General Public in France

Evaluation of the Practicability of Biosynex Antigen Self-Test COVID-19 AG+ for the Detection of SARS-CoV-2 Nucleocapsid Protein from Self-Collected Nasal Mid-Turbinate Secretions in the General Public in France

How COVID-19 Has Affected Caregivers’ Burden of Patients with Dementia: An Exploratory Study Focusing on Coping Strategies and Quality of Life during the Lockdown

The Impact of COVID-19 On Comorbidities: A Review Of Recent Updates For Combating It

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