The Impact of COVID-19 On Comorbidities: A Review Of Recent Updates For Combating It

Malik, Jonaid Ahmad; Ahmed, Sakeel; Shinde, Mrunal; Al-Marmash, Mohammed Hajjaj Saeid; Alghamdi, Saleh; Hussain, Arshad; Anwar, Sirajudheen

doi:10.1016/j.sjbs.2022.02.006

Cited by 60 publications

(37 citation statements)

References 127 publications

(106 reference statements)

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“…A recent review by Malik et al. has described the pathophysiology of COVID-19 and its pathophysiology on various pre-existing pathological conditions such as cardiovascular complications (cardiovascular disease and myocarditis, acute myocardial infraction, chronic myocardial infraction, cardiomyopathy), neurological consequences (Parkinson's diseases, Autism spectrum disease, Guillain-Barre Syndorme, acute cerebrovascular disease, encephalitis, encephalopathy), cancer, hemophagocytic lymphohistiocytosis, hypertension, diabetes milletus, and other infections (mucormycosis and ganagrene) [ 50 ]. The article provided a link with ACE2 and cardiac injury among COVID-19 cases.…”

Section: Discussionmentioning

confidence: 99%

“…The article provided a link with ACE2 and cardiac injury among COVID-19 cases. Interestingly an in vivo study documented an ACE2 dependent cardiac injury in SARS-CoV2 infected mouse models [ 50 , 51 ]. In the present study, we observed an elevated level of sACE2 in male patients with severe COVID-19 compared to female patients, indicating that male patients are more susceptible to SARS-CoV-2 infection with increasing disease severity.…”

Section: Discussionmentioning

confidence: 99%

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Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2

et al. 2022

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“…In addition to these factors, changes in laboratory indices and pro-inflammatory cytokines, as well as possible complications, could indicate the progression of COVID-19 into a severe and critical stage. 7 , 8 , 9 , 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

Short and Long-Term Impact of COVID-19 Infection on Previous Respiratory Diseases

Chiner-Vives

Cordovilla-Pérez

Rosa-Carrillo

et al. 2022

Archivos de Bronconeumología

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“…COVID-19 is an emerging infection, especially the highly infectious Omicron variant, which poses a challenge to population health and economic development worldwide. 28 In this study, some patients had an extremely long recovery time, which reached 22 days for some patients (n=8, 2.5%), and the prolonged viral load poses a challenge to the facilities of isolation sites. In China, due to the imbalance in health care resources and a rapidly ageing society, strict adherence to the zero-COVID-19 policy will do more good than harm to the overall health of the population.…”

Section: Discussionmentioning

confidence: 74%

Age and Sex Differences Among Mildly Symptomatic and Asymptomatic Patients with Omicron Infection in 2022 in Shanghai, China

Feng¹,

Hong²,

Fan³

et al. 2022

JMDH

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Background An epidemic of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in March 2022, and over 600,000 cases were confirmed until early May 2022 in Shanghai, China. Data on Omicron infections are available in other countries, but the clinical features of patients in the Chinese population, especially in Shanghai, are still lacking. We collected data from a subset of asymptomatic and mildly ill patients to learn about the age and sex disparity of Omicron infection based on changes in cycle threshold values. Methods The basic information of 325 patients who were consecutively admitted to the Shanghai Geriatrics Center was collected through medical records, and patients were tested for viral nucleic acid carriage using nasal swab samples during hospitalization. SAS 9.4 was used for data analysis, and a p value < 0.05% was considered statistically significant. Results Among the 325 included patients, 58.8% were males, with a mean age of 47.2 years and 13.6 days of hospitalization on average. The average number of nucleic acid tests among female patients was 4.7, which was higher than that among male patients (4.1). The median value of the slope for cycle threshold (Ct) changes in the nucleic acid detection (NAD) test was 1.4. Logistic regression indicated that the proportion of slope for Ct changes >1.5 was slightly higher among male patients than among female patients (odds ratio (OR) = 1.06, 95% confidence interval (CI): 0.68–1.66), and patients aged <45 years and 45–59 years had a higher proportion of slope for Ct changes >1.5 than patients aged ≥60 years. Ct values were more variable in the early stages of infection and stabilized in the later stages of infection. Conclusion Among patients with mild illness or asymptomatic infection, the Ct value is a good, timely, and cost-effective method to reflect the recovery progress of patients. The slope of Ct changes was steeper among younger patients and male patients, which indicates faster disease recovery.

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The Impact of COVID-19 On Comorbidities: A Review Of Recent Updates For Combating It

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Cited by 60 publications

References 127 publications

Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2

Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2

Short and Long-Term Impact of COVID-19 Infection on Previous Respiratory Diseases

Age and Sex Differences Among Mildly Symptomatic and Asymptomatic Patients with Omicron Infection in 2022 in Shanghai, China

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