COVID-19: A critical care perspective informed by lessons learnt from other viral epidemics

Ling, Lowell; Joynt, Gavin M.; Lipman, J; Constantin, Jean-Michel; Joannès-Boyau, Olivier

doi:10.1016/j.accpm.2020.02.002

Cited by 28 publications

(30 citation statements)

References 33 publications

(46 reference statements)

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“…Nevertheless, the lack of institutional preparedness for the occurrence of disasters leads to poor disaster preparedness (Huriah and Farida, 2010). Considering a high gap of knowledge about COVID-19 management, community organizations need to contribute to create a database related to COVID-19 at the local, regional, and international levels (Ling et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Preparedness for the Covid-19 Pandemic Management in Indonesia

Firmansyah

Rahmanto

Setiawan

2020

JAKI

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Background: The increase in disaster events requires preparedness from health workers as the frontline to provide medical services in handling victims when a disaster occurs. Many of medical workers infected with COVID-19 where at least 47 nurses in Indonesia have tested positive with the number of nurses having ODP and PDP status totaling 546 people and 44 people cause additional problem in handling COVID-19.Aims: This article aims to determine the readiness of health workers in handling pandemic disasters in suppressing the potential risks due to the COVID-19 outbreak through medical services provided.Methods: The research method used is descriptive qualitative with a literature study approach. Secondary data collection techniques from previous references and public documents related to COVID-19 disaster management in Indonesia. Data analysis using NVivo12 Plus software with a query analysis approach.Results: The results showed the ratio of health workers in Indonesia for medical services in handling the COVID-19 pandemic disaster was not ideal were for doctors 0.4 and nurses 2.1 were still far behind from developed countries where the ratio of health workers was above 2.5 doctors and 5.5 for nurses. Then, infrastructure aspects in general for referral hospitals handling COVID-19 almost in every province that has supported through the distribution of medical material equipment to various regions, provinces and districts, as well as hospitals that need it in all areas of Indonesia in the form of surgical masks (1,997,684 pieces), PPE of 1,659,955 units, coupled with Rapid Test equipment of 1,011,130 units.Conclusion: The readiness of health workers in providing medical services for the handling of a pandemic disaster influenced by the number of human resources, operational standards, and facilities for health facilities.

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Section: Introductionmentioning

confidence: 99%

The Preparedness for the Covid-19 Pandemic Management in Indonesia

Firmansyah

Rahmanto

Setiawan

2020

JAKI

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“…The patients admitted to the ICU were older and had a greater number of comorbid conditions than those not admitted to the ICU. Clinical symptoms are not obviously serious among COVID-19 cases and may be explained by molecule virology: SARS-Cov-2 likely uses human angiotensin-converting enzyme 2 as the entry receptor, [10][11][12] which is found primarily in the lower respiratory tract, rather than in the upper airway. 13 Only 5 (12.8%) of the 39 confirmed COVID-19 cases in this study were admitted to the intensive care unit, whereas in Wuhan, based on early reports, the percentage was in the range of 26-32%.…”

Section: Discussionmentioning

confidence: 99%

<p>Difference in Biomarkers Between COVID-19 Patients and Other Pulmonary Infection Patients</p>

Dai¹,

Du²,

Gao³

et al. 2020

IDR

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Background: The pandemic due to the novel coronavirus disease 2019 (COVID-19) has resulted in an increasing number of patients need to be tested. We aimed to determine if the use of integrated laboratory data can discriminate COVID-19 patients from other pulmonary infection patients. Methods: This retrospective cohort study was conducted at Kunming Third People's Hospital in China from January 20 to February 28, 2020. Medical records and laboratory data were extracted and combined for COVID-19 and other pulmonary infection patients on admission. A partial least square discriminant analysis (PLS-DA) model was constructed and calibrated to discriminate COVID-19 from other pulmonary infection patients. Results: COVID-19 patients diagnosed and treated in Kunming were balanced in terms of sex and covered all age groups. Most of them were mild cases; only five were severe cases. The first two dimensions of the PLS-DA model could classify COVID-19 and other pulmonary infection patients with an accuracy of 96.6% (95.1% in the cross-validation model). Basophil count, the proportion of basophils, prothrombin time, prothrombin time activity, and international normalized ratio were the five most discriminant biomarkers. Conclusion: Integration of biomarkers can discriminate COVID-19 patients from other pulmonary infections on admission to hospital and thus may be a supplement to nucleic acid tests.

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“…Liu, Zhou, et al, 2020 have discussed some patents disclose methodologies for treating and preventing CoV infections, which may be applicable to COVID‐19. As respiratory failure is the most important findings of COVID‐19, attention should be given for critically ill patients during mechanical ventilation in hospitals (Linga, Joynta, Lipman, Constantine, & Joannes‐Boyau, 2020). Till date, more than 500 clinical trials (randomized/ non‐randomized) were registered with standard of care.…”

Section: Possible Vaccines For Covid‐19 Pneumoniamentioning

confidence: 99%

The recent challenges of highly contagious COVID‐19, causing respiratory infections: Symptoms, diagnosis, transmission, possible vaccines, animal models, and immunotherapy

Mohapatra¹,

et al. 2020

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COVID‐19 is highly contagious pathogenic viral infection initiated from Wuhan seafood wholesale market of China on December 2019 and spread rapidly around the whole world due to onward transmission. This recent outbreak of novel coronavirus (CoV) was believed to be originated from bats and causing respiratory infections such as common cold, dry cough, fever, headache, dyspnea, pneumonia, and finally Severe Acute Respiratory Syndrome (SARS) in humans. For this widespread zoonotic virus, human‐to‐human transmission has resulted in nearly 83 lakh cases in 213 countries and territories with 4,50,686 deaths as on 19 June 2020. This review presents a report on the origin, transmission, symptoms, diagnosis, possible vaccines, animal models, and immunotherapy for this novel virus and will provide ample references for the researchers toward the ongoing development of therapeutic agents and vaccines and also preventing the spread of this disease.

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COVID-19: A critical care perspective informed by lessons learnt from other viral epidemics

Cited by 28 publications

References 33 publications

The Preparedness for the Covid-19 Pandemic Management in Indonesia

The Preparedness for the Covid-19 Pandemic Management in Indonesia

<p>Difference in Biomarkers Between COVID-19 Patients and Other Pulmonary Infection Patients</p>

The recent challenges of highly contagious COVID‐19, causing respiratory infections: Symptoms, diagnosis, transmission, possible vaccines, animal models, and immunotherapy

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