Covert COVID-19 complications: Continuing the use of evidence-based drugs to minimize potentially lethal indirect effects of the pandemic in stroke patients

Lee, Meng; Chen, Chi-Hsin Sally; Ovbiagele, Bruce

doi:10.1016/j.jns.2020.116883

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…In turn, for patients with systemic arterial hypertension, it is recommended to pause the use of angiotensin II inhibitors or the renin angiotensin system inhibitors, considering calcium blockers, diuretics and other classes of hypertensive 6 . Patients with atrial fibrillation using antithrombotics can be at increased risk of developing stroke and systemic embolism, when associated with infection by coronavirus 42 .…”

Section: Discussionmentioning

confidence: 99%

Stroke in Covid-19 Patients: A Scoping Review

Neto

Feitosa

Cunha

et al. 2021

Texto contexto - enferm.

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Objective: to map the scientific production on patients infected by COVID-19 and the occurrence of stroke. Method: a scoping review, according to the framework proposed by the Joanna Briggs Institute, using the LILACS, MEDLINE, WoS, EMBASE, CINAHL and SCOPUS databases, from April to September 2020. The following keywords were used: coronavirus infections, stroke, nervous system diseases and inpatients, based on the Medical Subject Headings. Results: 24 studies that evidenced specific clinical symptoms of stroke such as dysarthria, facial paralysis, sensory deficit, headache, hemiparesis and ataxia in patients with COVID-19 were included. The association between stroke and COVID-19 was found by the following exams: C-reactive protein, D-dimer, computed tomography and, magnetic resonance, among others, as well as by care procedures focused on the findings in the exams, associated with three clinical outcomes, based on the brain ischemia zone affected and the time of viral manifestation of each patient. Conclusion: the specific clinical manifestations of patients who suffered a stroke after COVID-19 were mapped, as well as diagnostic procedures and therapies used, in addition to identifying neurological damage based on the clinical outcome of these patients.

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Section: Discussionmentioning

confidence: 99%

Stroke in Covid-19 Patients: A Scoping Review

Neto

Feitosa

Cunha

et al. 2021

Texto contexto - enferm.

View full text Add to dashboard Cite

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“…Also, previous risk modifying therapies must not be discontinued. The most challenging patient management problems are necessity to regular blood tests to monitor international normalized ratios and significant future cerebrocardiovascular event risk increasing in discontinuation of antihypertensive, anticoagulant, and statin therapy [53]. Despite recommended anticoagulation regimens, some evidence notifies the increasing risk of adverse bleeding events including intracranial hemorrhage (ICH), parenchymal hemorrhage, punctuate hemorrhage, and small to large size hemorrhage with or without herniation in patients receiving either prophylactic or therapeutic doses [54].…”

Section: Clinical Approach and Recommended Therapiesmentioning

confidence: 99%

Update on cerebrovascular manifestations of COVID-19

Naeimi

Ghasemi-Kasman

2020

Neurol Sci

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The novel member of coronaviruses family, severe acute respiratory coronavirus-2 (SARS-CoV-2), with high structural homology to SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS) has spread rapidly with about 20 million cases infection and over 700,000 deaths. SARS-CoV-2 has been emerged as a worldwide disaster due to non-specific few respiratory and gastrointestinal manifestations at the onset of disease as well as long incubation period. Surprisingly, not only respiratory failure but also the underlying coagulation disorder and neurovascular involvement worsen the clinical outcome of infected patients. In this review article, we describe the probable mechanisms of SARS-CoV-2 infection and stroke occurrence. We will also discuss the cerebrovascular events following SARS-CoV-2 infection, the recommended therapies, and future prospects to better manage these patients in coronavirus disease 2019 (COVID-19) outbreak.

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“…Although neurological involvement is not common in COVID-19, symptoms such as encephalopathy, impaired consciousness, and skeletal muscle injury may indicate acute cerebrovascular disease (Ling et al, 2020). Evidence suggests that there is a 2.5-fold increase in the risk of developing severe COVID-19 in patients with a history of stroke (Lee et al, 2020), prompting clinicians to be vigilant for COVID-19 in cases of cerebrovascular accidents. Scientific reports emphasize the need for research to enhance our understanding of the neurological implications of COVID-19 (Avula et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Prediction of Stroke After the COVID-19 Infection

Babaee

Atashgar

Harandi

et al. 2024

BCN

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Background: Although several different studies have been published about COVID-19, ischemic stroke is known yet as a complicated problem for COVID-19 patients. Scientific reports indicate that in many cases, the incidence of stroke in patients with COVID-19 leads to death. Objectives: The obtained mathematical equation in this study can help physicians’ decision-making about treatment and identification of influential clinical factors for early diagnosis. Methods: In this retrospective study, data of 128 patients between March and September 2020 including demographic information, clinical characteristics and laboratory parameters of patients were collected and analyzed statistically. A logistic regression (LR) model was developed to identify the significant variables for the prediction of stroke incidence in patients with COVID-19. Results: Clinical characteristics and laboratory parameters for 128 patients (including 76 males, 52 females; with mean age 57.109 ± 15.97years) were considered as the inputs that included: ventilator dependence, comorbidities and laboratory tests including WBC, Neutrophil, lymphocyte, platelet count, C-Reactive Protein, Blood Urea Nitrogen, Alanine transaminase (ALT), Aspartate transaminase (AST) and LDH. The indexes such as receiver operating characteristic–area under the curve (ROC-AUC) and accuracy, sensitivity, and specificity were considered to determine the model capability. The accuracy of the model classification was also addressed by 93.8%. The area under the curve indicated 97.5% with a 95% confidence interval. Conclusion: The findings showed that ventilator dependence and Cardiac Ejection Fraction and LDH are associated with the occurrence of stroke and the proposed model can predict the stroke effectively.

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Covert COVID-19 complications: Continuing the use of evidence-based drugs to minimize potentially lethal indirect effects of the pandemic in stroke patients

Cited by 3 publications

References 5 publications

Stroke in Covid-19 Patients: A Scoping Review

Stroke in Covid-19 Patients: A Scoping Review

Update on cerebrovascular manifestations of COVID-19

Prediction of Stroke After the COVID-19 Infection

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