Cover Picture: Macromol. Biosci. 7/2006

Bergen, Jamie M.; Recum, Horst A. von; Goodman, Thomas T.; Massey, Archna P.; Pun, Suzie H.

doi:10.1002/mabi.200690012

Cited by 34 publications

(44 citation statements)

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“…It also implicated that ICG molecules were wellprotected by MSN-TA for in vivo imaging, and the confined space of MSN-TA might impede ICG being metabolized by enzymes presence in liver. Liver accumulation was also observed in the previous works on other types of nanoparticles (i.e., liposomes, [37] chitosan, [38] magnetite, [39] gold nanoparticles, [40] and carbon nanotubes [41] ). A preliminary validation of the noninvasive imaging capability of MSN-TA-ICG was performed by imaging its biodistribution in anesthetized nude mice.…”

Section: Full Papermentioning

confidence: 52%

Near‐Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution

Lee

Cheng

Wang

et al. 2009

Adv Funct Materials

282

140

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The characterization of near‐infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN‐TA) with the average size of 50–100 nm was synthesized with incorporation of the TA groups into the framework of MSN. It was further adsorbed with indocyanine green (ICG) by electrostatic attraction to render MSN‐TA‐ICG as an efficient NIR contrast agent for in vivo optical imaging. The studies in stability of MSN‐TA‐ICG against pH indicated the bonding is stable over the range from acidic to physiological pH. The in vivo biodistribution of MSN‐TA‐ICG in anesthetized rat demonstrated a rather strong and stable fluorescence of MSN‐TA‐ICG that prominent in the organ of liver. Transmission electron microscopy (TEM) imaging and elemental analysis of silicon further manifested the physical and quantitative residences of MSN‐TA‐ICG in major organs. This is the first report of MSN functionalized with NIR‐ICG capable of optical imaging in vivo.

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Section: Full Papermentioning

confidence: 52%

Near‐Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution

Lee

Cheng

Wang

et al. 2009

Adv Funct Materials

282

140

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“…The mentioned applications often call for monodisperse nanoparticles of a particular size in large quantities and/or at high concentrations [19,20]. Therefore, it is important to understand how changes in the synthesis conditions can affect the nanoparticle characteristics.…”

Section: Introductionmentioning

confidence: 99%

Effect of high gold salt concentrations on the size and polydispersity of gold nanoparticles prepared by an extended Turkevich–Frens method

et al. 2012

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The Turkevich-Frens synthesis starting conditions are expanded, ranging the gold salt concentrations up to 2 mM and citrate/gold(III) molar ratios up to 18:1. For each concentration of the initial gold salt solution, the citrate/gold(III) molar ratios are systematically varied from 2:1 to 18:1 and both the size and size distribution of the resulting gold nanoparticles are compared. This study reveals a different nanoparticle size evolution for gold salt solutions ranging below 0.8 mM compared to the case of gold salt solutions above 0.8 mM. In the case of [Au 3+ ]<0.8 mM, both the size and size distribution vary substantially with the citrate/gold(III) ratio, both displaying plateaux that evolve inversely to [Au 3+ ] at larger ratios. Conversely, for [Au 3+ ]≥0.8 mM, the size and size distribution of the synthesized gold nanoparticles continuously rise as the citrate/gold(III) ratio is increased. A starting gold salt concentration of 0.6 mM leads to the formation of the most monodisperse gold nanoparticles (polydispersity index< 0.1) for a wide range of citrate/gold(III) molar ratios (from 4:1 to 18:1). Via a model for the formation of gold nanoparticles by the citrate method, the experimental trends in size could be qualitatively predicted: the simulations showed that the destabilizing effect of increased electrolyte concentration at high initial [Au 3+ ] is compensated by a slight increase in zeta potential of gold nanoparticles to produce concentrated dispersion of gold nanoparticles of small sizes.

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“…Galactose-PEG-thiol ligand on AuNPs effectively resulted in hepatocyte targeted delivery in vivo. 5 The influence of anchoring ligands and particle size on the colloidal stability of PEG-coated AuNPs has also been reported. 6 This study suggests that AuNPs (20 nm) coated with thioctic acidterminated PEG (MW 5,000) are promising for potential drug delivery vehicles.…”

Section: Introductionmentioning

confidence: 99%

“…4 Bergen et al reported that the modification of AuNPs surface with PEG-thiol or galactose-PEG-thiol afforded steric stabilization at physiological salt concentrations under conditions where unmodified AuNPs aggregated. 5 In addition, PEG modification does not significantly affect the surface charge and size of AuNPs. Galactose-PEG-thiol ligand on AuNPs effectively resulted in hepatocyte targeted delivery in vivo.…”

Section: Introductionmentioning

confidence: 99%

Conjugation of Ginsenoside Rg3 with Gold Nanoparticles

Park¹,

Im²,

Joo³

et al. 2011

Bulletin of the Korean Chemical Society

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Ginsenoside Rg3 was reported to have important biological activities. We demonstrate conjugation and quantification procedures of ginsenoside Rg3 to gold nanoparticles for future biological and medical applications. Ginsenoside Rg3 was conjugated to spherical gold nanoparticles using a bifunctional heptaethylene glycol linker. The sulfhydryl group of heptaethylene glycol was adsorbed onto gold nanoparticles, and carboxylic acid end of heptaethylene glycol was bonded through a hydroxyl group of Rg3 via ester bond formation. The conjugation of Rg3 was characterized with various spectroscopic techniques, high resolution-transmission electron microscopy, and using Rg3 monoclonal antibody. The Rg3-functionalized gold nanoparticles were 4.7 ± 1.0 nm in diameter with a surface charge of -4.12 mV. The total number of Rg3 molecules conjugated to a 3.6 mL solution of gold nanoparticle was determined to be 9.5 × 10 14 corresponding to ~6 molecules of Rg3/gold nanoparticle. These results suggest that ginsenoside Rg3 is successfully conjugated to gold nanoparticles via heptaethylene glycol linker. The quantification was performed by using Rg3 monoclonal antibody without interference of gold's intrinsic color.

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Cover Picture: Macromol. Biosci. 7/2006

Cited by 34 publications

References 0 publications

Near‐Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution

Near‐Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution

Effect of high gold salt concentrations on the size and polydispersity of gold nanoparticles prepared by an extended Turkevich–Frens method

Conjugation of Ginsenoside Rg3 with Gold Nanoparticles

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