2016
DOI: 10.1111/bjd.15039
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Cover Image: Detection of hair follicle-associated Merkel cell polyomavirus in an immunocompromised host with follicular spicules and alopecia

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Cited by 6 publications
(5 citation statements)
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“…MCPyV‐induced transformation of skin appendage‐derived cells or even directly of cells from the hair follicle or other appendages suggests that MCPyV is able to infect these cells. Interestingly, expression of MCPyV T antigens in hair follicles has been reported in a case of alopecia 48 . In addition, we also describe LT/VP1 expression in hair follicle cells in the current study.…”
Section: Discussionsupporting
confidence: 65%
See 1 more Smart Citation
“…MCPyV‐induced transformation of skin appendage‐derived cells or even directly of cells from the hair follicle or other appendages suggests that MCPyV is able to infect these cells. Interestingly, expression of MCPyV T antigens in hair follicles has been reported in a case of alopecia 48 . In addition, we also describe LT/VP1 expression in hair follicle cells in the current study.…”
Section: Discussionsupporting
confidence: 65%
“…Interestingly, expression of MCPyV T antigens in hair follicles has been reported in a case of alopecia. 48 In addition, we also describe LT/VP1 expression in hair follicle cells in the current study. The respective small-sized (1.2 mm diameter) MCC sample may represent a "young" tumour, which, due to its visible location on the face, was excised early enough to still display initial steps of MCC development allowing detection of a follicular "in situ" MCC component as well as adjacent MCPyV-infected hair follicle cells.…”
Section: Discussionmentioning
confidence: 86%
“…A subsequent report of cryoglobulins accumulation in follicular content obtained from a patient with multiple myeloma supports this finding [3]. Besides, there has been speculation that Merkel cell polyomavirus, Propionibacterium acne , and Demodex folliculorum are the causes of the disease [15, 19, 20, 21, 22, 23]. However, there is a lack of evidence to support that these microorganisms play a role in the disease pathogenesis.…”
Section: Discussionmentioning
confidence: 87%
“…To our knowledge, our patient is the second reported case of idiopathic follicular hyperkeratotic spicules. Previously reported cases of this disorder are demonstrated in Table 1 and Table 2 [1, 2, 3, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23].…”
Section: Discussionmentioning
confidence: 99%
“…The potential of skin fibroblasts to be reprogrammed to MCC cells is supported by the recent finding that expression of MCPyV LT-t in these cells can induce the neuroendocrine-like growth characteristics of MCC (98). Alternatively, MCPyV actively replicating in the dermal fibroblasts may unintentionally enter the precursor cells of Merkel cells residing in their immediate vicinity, either within the basal layer of the epidermis or inside hair follicles (99). The nonpermissive propagation environment created as these cells develop into Merkel cells may force the replication-defective MCPyV genome to integrate into the host cell genome, eventually leading to oncogenesis (Figure 4).…”
Section: The Cell Origin Of Merkel Cell Carcinomamentioning
confidence: 98%