Covalently Linked Au Nanoparticles to a Viral Vector:  Potential for Combined Photothermal and Gene Cancer Therapy

Everts, Maaike; Saini, Vaibhav; Leddon, Jennifer L.; Kok, Robbert J.; Stoff-Khalili, Mariam A.; Preuss, Meredith A.; Millican, C L; Perkins, Guy; Brown, Joshua; Bagaria, Hitesh G.; Nikles, David E.; Johnson, Dylan; Zharov, Vladimir P.; Curiel, David T.

doi:10.1021/nl0500555

Cited by 243 publications

(169 citation statements)

References 23 publications

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“…However, their effectiveness in vivo may be reduced. New targeting strategies, such as one demonstrated recently based on an adenoviral vector, should be pursued actively [75]. Also, standardized, quantitative assays for bioconjugated nanoparticles are required to determine their activity over biological applications.…”

Section: Future Perspectivesmentioning

confidence: 99%

Biomedical Applications of Plasmon Resonant Metal Nanoparticles

2006

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The strong optical absorption and scattering of noble metal nanoparticles is due to an effect called localized surface plasmon resonance, which enables the development of novel biomedical applications. The resonant extinction, which can be tuned to the near-infrared, allows the nanoparticles to act as molecular contrast agents in a spectral region where tissue is relatively transparent. The localized heating due to resonant absorption, also tunable into the near-infared, enables new thermal ablation therapies and drug delivery mechanisms. The sensitivity of these resonances to their environment leads to simple affinity sensors for the detection of low-level molecular analytes. Coupled with their general lack of toxicity, these applications suggest that noble metal nanoparticles are a highly promising class of nanomaterials for new biomedical applications.

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Section: Future Perspectivesmentioning

confidence: 99%

Biomedical Applications of Plasmon Resonant Metal Nanoparticles

2006

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“…Nevertheless, to our knowledge, this was the first demonstration of the application of nanotechnology to treat blood vessels with laser-activaded gold nanoparticles and their nanoclusters [148][149][150][151][152][153][154] .…”

Section: High-power Laser Treatment Of Vascular Abnormalitiesmentioning

confidence: 99%

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Galanzha¹

2007

WJG

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Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo . Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell's functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo-and radio-sensitivity tests, and drug screening, are also discussed. TOPIC HIGHLIGHT

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“…However, these carriers do not absorb NIR-region light, and thus cannot themselves act as PHT agents. In contrast, gold nanoparticles (40) and gold nanoshells (41) do absorb NIR light and could be useful as PHT agents. However, the gold nanoparticles do not have nanospaces large enough to incorporate drugs and are difficult to modify.…”

mentioning

confidence: 99%

Fabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapy

Zhang

Murakami

Ajima

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

250

186

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Multifunctionalization of carbon nanotubules is easily achieved by attaching functional molecules that provide specific advantages for microscopic applications. We fabricated a double photodynamic therapy (PDT) and photohyperthermia (PHT) cancer phototherapy system that uses a single laser. Zinc phthalocyanine (ZnPc) was loaded onto single-wall carbon nanohorns with holes opened (SWNHox), and the protein bovine serum albumin (BSA) was attached to the carboxyl groups of SWNHox. In this system, ZnPc was the PDT agent, SWNHox was the PHT agent, and BSA enhanced biocompatibility. The double phototherapy effect was confirmed in vitro and in vivo. When ZnPc-SWNHox-BSA was injected into tumors that were subcutaneously transplanted into mice, the tumors almost disappeared upon 670-nm laser irradiation. In contrast, the tumors continued to grow when only ZnPc or SWNHox-BSA was injected. We conclude that carbon nanotubules may be a valuable new tool for use in cancer phototherapy.carbon nanotubules ͉ drug carrier ͉ drug delivery system ͉ nanoparticle ͉ photohyperthermia

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Covalently Linked Au Nanoparticles to a Viral Vector: Potential for Combined Photothermal and Gene Cancer Therapy

Cited by 243 publications

References 23 publications

Biomedical Applications of Plasmon Resonant Metal Nanoparticles

Biomedical Applications of Plasmon Resonant Metal Nanoparticles

Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screening

Fabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapy

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