Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing

Chen, Huinan; Xing, Xiaodong; Tan, Huaping; Yang, Jia; Zhou, Ting; Chen, Yong; Ling, Zhonghua; Hu, Xiaohong

doi:10.1016/j.msec.2016.08.086

Cited by 302 publications

(140 citation statements)

References 41 publications

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“…Dari sepuluh artikel yang ditinjau, semua penelitian yang dilakukan review paper ini menggunakan study design eksperimental (Shahzad et al, 2015;Chen et al, 2017;Ng & Leow, 2015;Jayakumar et al, 2015;Sebria & Amin, 2016;Phaechamud et al, 2016;Kurczewska et al, 2017;Güneş & Tıhmınlıoğlu, 2017;Blandón et al, 2016;Hajimirzababa et al, 2017). Terdapat tiga penelitian menggunakan hidrogel (Shahzad et al, 2015;Chen et al, 2017;Sebria & Amin, 2016), dua penelitian menggunakan natural rubber films dan chitosan films (Phaechamud et al, 2016;Güneş & Tıhmınlıoğlu, 2017), dan satu penelitian menggunakan biofilm (Ng & Leow, 2015), serta empat penelitian menggunakan alginate (Jayakumar et al, 2015;Kurczewska et al, 2017;Blandón et al, 2016;Hajimirzababa et al, 2017).…”

Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

“…Terdapat tiga penelitian menggunakan hidrogel (Shahzad et al, 2015;Chen et al, 2017;Sebria & Amin, 2016), dua penelitian menggunakan natural rubber films dan chitosan films (Phaechamud et al, 2016;Güneş & Tıhmınlıoğlu, 2017), dan satu penelitian menggunakan biofilm (Ng & Leow, 2015), serta empat penelitian menggunakan alginate (Jayakumar et al, 2015;Kurczewska et al, 2017;Blandón et al, 2016;Hajimirzababa et al, 2017).…”

Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

“…Terdapat tiga artikel yang mengatakan hidrogel mempunyai antibakteri yang dapat menghambat Staphylococcus Aureus dan Escherichia coli, merupakan mikroorganisme penyebab utama pada luka kronis (Shahzad et al, 2015). Hidrogel menunjukkan antibakteri dari 30 mg / mL GM / Gel ganti melawan Escherichia coli dan Staphylococcus Aureus (Chen et al, 2017). Sedangkan Hidrogel GG dapat menghambat bakteri Gram positif, yaitu Staphylococcus Aureus (Sebria & Amin, 2016).…”

Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

“…Karena, Antimikroba yang ada pada balutan luka dapat membunuh bakteri yang ada pada luka (Darwis, Basyir, Hardiningsih, & Chosdu, 2013). Jenis antimikroba yang digunakan dalam modern wound dressing seperti: Cefixime (Shahzad et al, 2015), Tetracycline (Chen et al, 2017), Gentamicin (Ng & Leow, 2015), Penicillin G-P10 (Sebria & Amin, 2016), Tetramethylrodamine (Jayakumar et al, 2015), Gentamicine Sulfate (Phaechamud et al, 2016), Vancomycin Hydrochloride (Kurczewska et al, 2017), Penicillin dan Streptomycin (Güneş & Tıhmınlıoğlu, 2017), Chiprofloxacine (Blandón et al, 2016) …”

Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

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Effectiveness of Modern Wound Dressing on the Growth of Staphylococcus Aureus Bacteria

Gito

Rochmawati

2018

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ABSTRAKLuka diklasifikasikan sebagai akut dan kronis. Tahap awal pembentukan luka kronis ditandai dengan munculnya organisme Gram-positif seperti Staphylococcus Aureus dan Escherichia coli. Pada tahap selanjutnya, Gram-negatif spesies Pseudomonas yang cenderung menyerang lapisan dalam pada luka. Modern wound dressing yang mengandung antimikroba telah dikembangkan sejak dua puluh tahun terakhir, efektif membunuh bakteri dan jamur pada luka, mencegah infeksi berulang selama penyembuhan . Tujuan review paper ini untuk melaporkan hasil analisa penelitian yang berfokus pada pengaruh modern wound dressing terhadap bakteri Staphylococcus Aureus. Pencarian artikel yang relevan menggunakan database PubMed dan search engine Google dengan menggunakan kata kunci "modern wound dressing","antibacterial", "staphylococcus". Sepuluh artikel yang sesuai dengan kriteria inklusi dimasukkan dalam review paper ini. Modern wound dressing dengan kandungan antimikroba dapat menghambat pertumbuhan bakteri. Dengan demikian, review paper ini dapat menjadi dasar untuk penelitian selanjutnya tentang efektifitas modern wound dressing terhadap bakteri Staphylococcus Aureus.

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Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

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Effectiveness of Modern Wound Dressing on the Growth of Staphylococcus Aureus Bacteria

Gito

Rochmawati

2018

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“…And gelatinbased nanoparticles could be degraded by MMP-2, and drug encapsulated could be quickly released in the tumor sites [10]. As previously described, gelatin-based micelles had the advantages of biocompatible and biodegradable properties without obvious toxicity and immunogenicity [11,12].…”

Section: Introductionmentioning

confidence: 97%

Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma

Fan

Yan

et al. 2018

Journal of Nanomaterials

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Hepatocellular carcinoma (HCC) is one of the most prevalent fatal diseases and the incidence of HCC is increasing worldwide. Polymeric micelles with targeting groups have drawn great attention as carriers for drug delivery in HCC therapy. Herein, novel glycyrrhetinic acid modified gelatin (GA-GEL) conjugates with three substitution degrees were synthesized and characterized. Doxorubicin (DOX) was applied as a model drug. DOX-loaded GA-GEL (DOX/GA-GEL) micelles were prepared by an emulsionsolvent evaporation method. The mean diameters of DOX/GA-GEL micelles were in the range of 195-235 nm. The encapsulation efficiency of DOX/GA-GEL micelles was 63.6%-96.2%, and the loading content was 8.3%-12.5%. Drug release from DOX-loaded micelles exhibited a biphasic manner in phosphate buffer solution (PBS) at pH 7.4. DOX/GA-GEL could be efficiently accumulated into human liver cancer HepG2 cells. The IC 50 values of DOX/GA-GEL-2 and DOX⋅HCl in HepG2 cells were 0.33 and 0.66 g/mL, respectively. In vivo imaging analysis demonstrated that the fluorescence signals of DiR-labeled GA-GEL-2 micelles were mainly distributed in liver and H22 orthotopic tumor, indicating that GA-GEL had the liver-targeting activity. Compared to DOX⋅HCl, DOX/GA-GEL-2 exhibited better antitumor activity in H22 orthotopic mice. Therefore, these results indicated that GA-GEL could be used as carrier of hydrophobic drug for targeting HCC.

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The Potential Role of Photobiomodulation and Polysaccharide‐Based Biomaterials in Wound Healing Applications

2017

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Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing

Cited by 302 publications

References 41 publications

Effectiveness of Modern Wound Dressing on the Growth of Staphylococcus Aureus Bacteria

Effectiveness of Modern Wound Dressing on the Growth of Staphylococcus Aureus Bacteria

Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma

The Potential Role of Photobiomodulation and Polysaccharide‐Based Biomaterials in Wound Healing Applications

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