Covalent Surface Modification Effects on Single‐Walled Carbon Nanotubes for Targeted Sensing and Optical Imaging

Chio, Linda; Pinals, Rebecca L.; Murali, Aishwarya; Goh, Natalie S.; Landry, Markita P.

doi:10.1002/adfm.201910556

Cited by 60 publications

(60 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The optical and electronic properties of single-walled carbon nanotubes (SWCNTs) have long been the focus of nanomaterials research, including the design of biosensors [1][2][3][4][5]. Consequently, modifying SWCNTs with biorecognition elements or biomolecules themselves is a key step in this process [6][7][8][9][10][11], and the functionalization of SWCNTs has been tailored through both covalent and non-covalent approaches [12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

DNA-Directed Assembly of Carbon Nanotube–Protein Hybrids

et al. 2021

View full text Add to dashboard Cite

Here, we report the controlled assembly of SWCNT–GFP hybrids employing DNA as a linker. Two distinct, enriched SWCNTs chiralities, (6,5), (7,6), and an unsorted SWCNT solution, were selectively functionalized with DNA and hybridized to a complementary GFPDNA conjugate. Atomic force microscopy images confirmed that GFP attachment occurred predominantly at the terminal ends of the nanotubes, as designed. The electronic coupling of the proteins to the nanotubes was confirmed via in-solution fluorescence spectroscopy, that revealed an increase in the emission intensity of GFP when linked to the CNTs.

show abstract

Section: Introductionmentioning

confidence: 99%

DNA-Directed Assembly of Carbon Nanotube–Protein Hybrids

et al. 2021

View full text Add to dashboard Cite

show abstract

“…As shown in Figure S10, Supporting Information, we performed the mapping using the excitation laser of 785 nm over a 180 µm × 180 µm area and obtained the RSD of 3.3% for the BPE sample, better than the R6G sample (i.e., 4.4%), validating the prediction of the chemical binding. On the other hand, it has been reported that introducing thiol groups to existing molecules or using thiol molecules as a bridge to connect molecules with sensing chips [ 82–84 ] can improve the sensing performance of non‐thiol‐based molecules. These emerging strategies are promising to expand the impact of the proposed nanogap sensing architectures.…”

Section: Resultsmentioning

confidence: 99%

Large‐Scale Sub‐1‐nm Random Gaps Approaching the Quantum Upper Limit for Quantitative Chemical Sensing

Zhang

Singer

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

Metallic nanostructures with nanogap features can confine electromagnetic fields into extremely small volumes. In particular, as the gap size is scaled down to sub‐nanometer regime, the quantum effects for localized field enhancement reveal the ultimate capability for light–matter interaction. Although the enhancement factor approaching the quantum upper limit has been reported, the grand challenge for surface‐enhanced vibrational spectroscopic sensing remains in the inherent randomness, preventing uniformly distributed localized fields over large areas. Herein, a strategy to fabricate high‐density random metallic nanopatterns with accurately controlled nanogaps, defined by atomic‐layer‐deposition and self‐assembled‐monolayer processes, is reported. As the gap size approaches the quantum regime of ≈0.78 nm, its potential for quantitative sensing, based on a record‐high uniformity with the relative standard deviation of 4.3% over a large area of 22 mm × 60 mm, is demonstrated. This superior feature paves the way towards more affordable and quantitative sensing using quantum‐limit‐approaching nanogap structures.

show abstract

“…In this work, we placed quantum defects in SWCNTs to perturb the fluorescence response to analyte molecules. Other studies focused more on covalent functionalization chemistry 60 . The data provided mechanistic insights into the sensing mechanism of SWCNT-based fluorescent sensors.…”

Section: Discussionmentioning

confidence: 99%

Quantum Defects in Fluorescent Carbon Nanotubes for Sensing and Mechanistic Studies

Spreinat¹,

Dohmen²,

Lüttgens³

et al. 2021

Preprint

View full text Add to dashboard Cite

<div><div><div><p>Single wall carbon nanotubes (SWCNT) fluoresce in the near infrared (NIR) and have been assembled with biopolymers such as DNA to form highly sensitive molecular sensors. They change their fluorescence when they interact with analytes. Despite the progress in engineering of these sensors the underlying mechanisms are still not understood. Here, we identify processes and rate constants that explain the photophysical signal transduction by exploiting sp3 quantum defects in the sp2 carbon lattice of SWCNTs. As a model system we use ssDNA coated (6,5)-SWCNTs, which increase their NIR emission (E11, 990 nm) up to + 250 % in response to the important neurotransmitter dopamine. In contrast, SWCNTs coated with DNA but with a low number of NO2-Aryl sp3 quantum defects decrease both their E11 (-35%) and defect related E11* emission (- 50%) at 1130 nm. Consequently, the interaction with the analyte does not change the radiative exciton decay pathway alone. Furthermore, the fluorescence response of pristine SWCNTs increases with SWCNT length, suggesting that exciton diffusion is affected. The quantum yield of pristine (6,5)-SWCNTs increases in response to the analyte from 0.6 % to 1.3 % and points to a change in non-radiative rate constants. These experimental results are explained by a Monte Carlo simulation of exciton diffusion, which supports a change of two non-radiative decay pathways together with an increase of exciton diffusion (3 rate constant model). The combination of such SWCNTs with defects and without defects enables the assembly of ratiometric sensors with opposing responses at different wavelengths. In summary, we demonstrate how perturbation of a system with quantum defects reveals the photophysical mechanism and reverses optical responses.</p></div></div></div>

show abstract

Covalent Surface Modification Effects on Single‐Walled Carbon Nanotubes for Targeted Sensing and Optical Imaging

Cited by 60 publications

References 42 publications

DNA-Directed Assembly of Carbon Nanotube–Protein Hybrids

DNA-Directed Assembly of Carbon Nanotube–Protein Hybrids

Large‐Scale Sub‐1‐nm Random Gaps Approaching the Quantum Upper Limit for Quantitative Chemical Sensing

Quantum Defects in Fluorescent Carbon Nanotubes for Sensing and Mechanistic Studies

Contact Info

Product

Resources

About