Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications

Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

“…The development of tumor-targeted intelligent diagnostic and therapeutic drugs based on TME characteristics is currently a popular cancer treatment strategy [ 218 , [303] , [304] , [305] , [306] ]. The high level of H 2 S in CRC cells makes it a promising endogenous microenvironment molecule for the design and synthesis of H 2 S-responsive diagnostic therapeutics targeting CRC.…”

“…Chemotherapeutics that are commonly used include doxorubicin (DOX), camptothecin (CPT), 5-FU, and curcumin (Cur), which are employed in the treatment of many cancers, including CRC [ 217 ]. However, chemotherapeutics have a number of limitations in their use, including rapid clearance after administration, non-specific distribution, and non-discriminatory damage to normal tissues [ 218 ]. As a result, scientists have been working for a long time to develop a drug carrier that can precisely control the on-demand release of chemotherapeutics in order to increase targeting to tumor tissues and improve therapeutic efficacy.…”

Recent advances in covalent organic frameworks (COFs) for wound healing and antimicrobial applications

“…98 The capability of COFs to disintegrate in a slightly acidic tumor microenvironment offers the advantage of targeted delivery. 99 However, more elaborative studies are still required pertaining to the synthesis of COFs and identification of optimal conditions. On the other hand, nanotoxicological assessments are crucial aspects in clinical and biomedical applications of nanomaterials, since they may cause possible harmful or toxic effects on human health or the environments.…”

Nanomaterials for photothermal cancer therapy

“…16,17 Due to the PTA with specic photophysical properties, it can be used for tumor imaging, such as thermal imaging, uorescence imaging (FL), and photoacoustic imaging (PAI), which has great potential for application in tumor visualization and treatment. 18,19 The effectiveness of PTT largely depends on the photothermal conversion efficiency of PTAs. 16,20,21 Therefore, it is critical to prepare PTAs with high photothermal conversion efficiency and strong NIR light absorption to achieve optimal PTT outcomes.…”