Covalent conjugation of carbon dots with Rhodamine B and assessment of their photophysical properties

Diac, Andreea; Focșan, Monica; Socaci, Crina; Gabudean, Ana-Maria; Farcău, Cosmin; Maniu, Dana; Vasile, Eugeniu; Terec, Anamaria; Veca, L. Monica; Aştilean, Simion

doi:10.1039/c5ra13161h

Cited by 35 publications

(16 citation statements)

References 32 publications

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“…As shown in Figure 6a, the absorption spectrum of RBITC features a typical band at 555 nm characteristic to the π-π* electronic transition in the xanthene ring [61]. Similar shifts of the absorbance peak were reported previously in other studies of Rhodamine conjugated to silver NPs or carbon dots (CD) [62,63]. Diac et al indicated the conversion of the isothiocyanate moiety in RBITC molecule to the thiourea upon the reaction with the terminal primary amine in the CD-PEG [58].…”

Section: Fluorescent Labelling Of Pt Nfssupporting

confidence: 86%

A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

Yang

Salado-Leza

Porcel

et al. 2020

IJMS

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Nanomedicine has stepped into the spotlight of radiation therapy over the last two decades. Nanoparticles (NPs), especially metallic NPs, can potentiate radiotherapy by specific accumulation into tumors, thus enhancing the efficacy while alleviating the toxicity of radiotherapy. Water radiolysis is a simple, fast and environmentally-friendly method to prepare highly controllable metallic nanoparticles in large scale. In this study, we used this method to prepare biocompatible PEGylated (with Poly(Ethylene Glycol) diamine) platinum nanoflowers (Pt NFs). These nanoagents provide unique surface chemistry, which allows functionalization with various molecules such as fluorescent markers, drugs or radionuclides. The Pt NFs were produced with a controlled aggregation of small Pt subunits through a combination of grafted polymers and radiation-induced polymer cross-linking. Confocal microscopy and fluorescence lifetime imaging microscopy revealed that Pt NFs were localized in the cytoplasm of cervical cancer cells (HeLa) but not in the nucleus. Clonogenic assays revealed that Pt NFs amplify the gamma rays induced killing of HeLa cells with a sensitizing enhancement ratio (SER) of 23%, thus making them promising candidates for future cancer radiation therapy. Furthermore, the efficiency of Pt NFs to induce nanoscopic biomolecular damage by interacting with gamma rays, was evaluated using plasmids as molecular probe. These findings show that the Pt NFs are efficient nano-radio-enhancers. Finally, these NFs could be used to improve not only the performances of radiation therapy treatments but also drug delivery and/or diagnosis when functionalized with various molecules.

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Section: Fluorescent Labelling Of Pt Nfssupporting

confidence: 86%

A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

Yang

Salado-Leza

Porcel

et al. 2020

IJMS

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“…FRET occurs without the appearance of a photon due to long range dipole-dipole interactions between CDs and quencher. The distance between the CDs and quencher was in the range of 10 Å-100 Å [19,[22][23][24]. The energy transfer efficiency (E) is calculated by following eq.…”

Section: Fret Mechanism Of Cdsmentioning

confidence: 99%

“…From that the CDs-quencher distance (r) and Förster distance (R 0 ) between the CDs and the quencher can be estimated by eq. 4-6: [22,23]…”

Section: Fret Mechanism Of Cdsmentioning

confidence: 99%

The quenching of the fluorescence of carbon dots: A review on mechanisms and applications

et al. 2017

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Carbon dots (CDs) possess unique optical properties such as tunable photoluminescence (PL) and excitation dependent multicolor emission. The quenching and recovery of the fluorescence of CDs can be utilized for detecting analytes. The PL mechanisms of CDs have been discussed in previous articles, but the quenching mechanisms of CDs have not been summarized so far. Quenching mechanisms include static quenching, dynamic quenching, Förster resonance energy transfer (FRET), photoinduced electron transfer (PET), surface energy transfer (SET), Dexter energy transfer (DET) and inner filter effect (IFE). Following an introduction, the review (with 88 refs.) first summarizes the various kinds of quenching mechanisms of CDs (including static quenching, dynamic quenching, FRET, PET and IFE), the principles of these quenching mechanisms, and the methods of distinguishing these quenching mechanisms. This is followed by an overview on applications of the various quenching mechanisms in detection and imaging.

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“…(3) The distance between the carbon dots and the quencher is 1–10 nm. [ 184–186 ] Soni et al. [ 136 ] used palm shell waste as biomass carbon source to synthesize N,S‐CQDs which could be applied to the detection of nitrophenol.…”

Section: Application Of Biomass Carbon Dots In Sensingmentioning

confidence: 99%

Recent advances of biomass carbon dots on syntheses, characterization, luminescence mechanism, and sensing applications

et al. 2021

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Carbon dots have attracted much attention due to their high fluorescence intensity, easy modification, good stability, and biocompatibility. However, the realization of low‐cost mass production of high‐quality carbon dots still faces great challenges. Biomass is of non‐toxic and environmentally friendly organism, but a lot of biomass is treated as waste for burning and landfill at present, causing irreparable pollution to the environment. In fact, many biomass resources are ideal candidates for preparing carbon dots. This review focuses on carbon dots including carbon quantum dots (CQDs) and graphene quantum dots (GQDs) which using biomass as carbon source on the aspects of plants and their derivatives, animals and their derivatives and municipal waste. The characterization of the structure and composition of biomass carbon dots, the regulation of fluorescence color and the methods of improving quantum yield (QY) including heteroatom doping and surface modification are introduced in detail. Moreover, biomass carbon dots for detecting metal ions and non‐metal molecules and their quenching mechanism are emphatically introduced in addition to summarizing the luminescence mechanism, and some promising prospects and challenges in this uplifting field are discussed.

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Covalent conjugation of carbon dots with Rhodamine B and assessment of their photophysical properties

Abstract: Applying the Förster formalism we studied the potential of urethane-like linkage at the surface of CDs to form donor–acceptor FRET pair in CD–Rhodamine conjugates.

Cited by 35 publications

References 32 publications

A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

The quenching of the fluorescence of carbon dots: A review on mechanisms and applications

Recent advances of biomass carbon dots on syntheses, characterization, luminescence mechanism, and sensing applications

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