Abstract:Recently, we detected a previously unknown Ser-Pro-Cys
(SPC) tripeptide
in the blood serum of multiple sclerosis patients. Its role as a biomarker
of the autoimmune disease was suggested, although its origin and real
biological activity remained unclear. Here, we created a biocompatible
PEGylated comb-like polymer that was used as a platform for covalent
immobilization of the SPC, which provided a possibility to explore
the biological activity of this tripeptide. This macromolecular conjugate
was synthesized v… Show more
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