Coupling Reactions and CH Functionalization

Alkoxycarbonylation-triggered nitrile insertion/remote C(sp2)–H and C(sp3)–H functionalization to access esterified quinazolinones and amidines

“…Based on our results and related literature, 20 a plausible reaction mechanism is proposed in Scheme 3b. 21 Initially, an ethoxycarbonyl radical is formed by decarbonylation of the acyl radical, which is generated by the reaction between ethyl chlorooxoacetate 2a and Ag 2 CO 3 under irradiation via single-electron transfer.…”

“…21 Initially, an ethoxycarbonyl radical is formed by decarbonylation of the acyl radical, which is generated by the reaction between ethyl chlorooxoacetate 2a and Ag 2 CO 3 under irradiation via single-electron transfer. 20 Intermediate A then adds to the CC bond in substrate 1a , yielding radical intermediate B . Subsequently, 5- exo-dig cyclization of intermediate B gives iminyl radical C , and then 6- endo-trig cyclization affords phenyl radical intermediate D .…”